Stephen C. Alley - Bothell WA, US Scott C. Jeffrey - Bothell WA, US Django Sussman - Bothell WA, US Dennis R. Benjamin - Bothell WA, US Brian Toki - Bothell WA, US Patrick J. Burke - Bothell WA, US
Assignee:
Seattle Genetics, Inc. - Bothell WA
International Classification:
C12N 5/06 C12N 5/00 C07K 16/00
US Classification:
435326, 5303871, 435375, 435405
Abstract:
The invention provides methods and compositions for preparing antibodies and antibody derivatives with reduced core fucosylation.
Methods And Compositions For Making Antibodies And Antibody Derivatives With Reduced Core Fucosylation
Stephen C. Alley - Bothell WA, US Scott C. Jeffrey - Bothell WA, US Django Sussman - Bothell WA, US Dennis R. Benjamin - Bothell WA, US Brian Toki - Bothell WA, US Patrick J. Burke - Bothell WA, US
Assignee:
Seattle Genetics, Inc. - Bothell WA
International Classification:
C12N 5/00
US Classification:
435405
Abstract:
The invention provides methods and compositions for preparing antibodies and antibody derivatives with reduced core fucosylation.
Robert Lyon - Sammamish WA, US Dennis Benjamin - Redmond WA, US Maureen Ryan - Bellevue WA, US
Assignee:
SEATTLE GENETICS, INC. - Bothell WA
International Classification:
C40B 30/04 G01N 21/75 C40B 50/14
US Classification:
506 9, 506 30
Abstract:
The invention provides methods for making antibody conjugates for use in antibody screening assays and antibody conjugates produced by the claimed methods.
Methods Of Inhibition Of Protein Fucosylation In Vivo Using Fucose Analogs
Peter Senter - Seattle WA, US Stephen Alley - Seattle WA, US Dennis Benjamin - Redmond WA, US
Assignee:
Seattle Genetics, Inc. - Bothell WA
International Classification:
A61K 31/7004 A61K 31/7048 A61K 31/7024
US Classification:
4242771, 514 23, 536 111, 536119
Abstract:
The invention provides methods and compositions for the inhibition of fucosylation of proteins, including antibodies, in vivo by administration of a fucose analog.
Antibody Drug Conjugates (Adc) That Bind To 24P4C12 Proteins
Seattle Genetics, Inc. - Bothell WA, US Zili AN - Santa Monica CA, US Robert Kendall MORRISON - Santa Monica CA, US Karen Jane Meyrick MORRISON - Santa Monica CA, US Xiao-chi JIA - Los Angeles CA, US Dennis BENJAMIN - Redmond WA, US Ruth MOSER - Bellevue WA, US Peter SENTER - Seattle WA, US
Assignee:
SEATTLE GENETICS, INC. - Bothell WA AGENSYS, INC. - Santa Monica CA
International Classification:
C07K 16/30 A61K 45/06 A61K 47/48
US Classification:
4241781
Abstract:
Antibody drug conjugates (ADC's) that bind to 24P4C12 protein and variants thereof are described herein. 24P4C12 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, the ADC's of the invention provide a therapeutic composition for the treatment of cancer.
Methods And Compositions For Making Antibodies And Antibody Derivatives With Reduced Core Fucosylation
Scott C. Jeffrey - Bothell WA, US Django Sussman - Bothell WA, US Dennis R. Benjamin - Bothell WA, US Brian Toki - Bothell WA, US Patrick J. Burke - Bothell WA, US
Assignee:
Seattle Genetics, Inc. - Bothell WA
International Classification:
C07H 13/04
US Classification:
536 182
Abstract:
The invention provides methods and compositions for preparing antibodies and antibody derivatives with reduced core fucosylation.
Methods And Compositions For Making Antibodies And Antibody Derivatives With Reduced Core Fucosylation
- Bothell WA, US Scott C. JEFFREY - Bothell WA, US Django SUSSMAN - Bothell WA, US Dennis R. BENJAMIN - Bothell WA, US Brian TOKI - Bothell WA, US Patrick J. BURKE - Bothell WA, US
International Classification:
C12N 5/00 C07K 16/00 C07H 13/04
Abstract:
The invention provides methods and compositions for preparing antibodies and antibody derivatives with reduced core fucosylation.
TEAM LEAD TECHNICAL REPRESENTATIVE at UNDER ARMOUR, TEAM LEAD TECHNICAL REPRESENTATIVE at UNDER ARMOUR UK
Location:
Rochester, United Kingdom
Work:
UNDER ARMOUR since May 2007
TEAM LEAD TECHNICAL REPRESENTATIVE
UNDER ARMOUR UK - London, United Kingdom since May 2007
TEAM LEAD TECHNICAL REPRESENTATIVE
Seattle Genetics - Bothell, WA since Mar 2013
Vice President
Seattle Genetics Dec 2004 - Mar 2013
Senior Director, Experimental Therapeutics
Praecis Pharmaceuticals Sep 1998 - Dec 2004
Director, Biochemistry
Genetics Institute Jun 1987 - Sep 1990
Scientist
Education:
University of Oxford 1995 - 1998
Hitchings-Elion Postdoctoral Fellow, Protein Chemistry
University of California, San Francisco 1990 - 1995
Ph.D, Medicinal Chemistry
Massachusetts Institute of Technology 1983 - 1987
B.Sc., Chemistry
Miami Palmetto Junior & Senior
Skills:
Biochemistry Drug Discovery Clinical Development Biotechnology Drug Development Oncology Chemistry Organic Chemistry Medicinal Chemistry Ind Purification Hplc Assay Development Life Sciences Lc Ms Protein Chemistry Pharmaceutical Industry Technology Transfer Biopharmaceuticals Mass Spectrometry High Performance Liquid Chromatography Liquid Chromatography Mass Spectrometry Protein Purification Molecular Biology Clinical Trials Translational Research Cancer Monoclonal Antibodies Research and Development
hearing for the most serious crimes. The state doesnt have a standardized process for reviewing the sentences of current juvenile lifers, so its typically up to each inmate to file for a resentencing. Idaho attorney Dennis Benjamin ensured all four inmates were aware of the high courts actions.