Dennis R Benjamin

US Patent:

7968687, Jun 28, 2011

Filed:

Oct 17, 2008

Appl. No.:

12/253895

Inventors:

Charlotte McDonagh - Waltham MA, US
Charles G. Cerveny - Seattle WA, US
Dennis Benjamin - Redmond WA, US
Paul Carter - Mercer Island WA, US

Assignee:

Seattle Genetics, Inc. - Bothell WA

International Classification:

C12P 21/08

US Classification:

5303873, 53038885, 5303911, 5303917

Abstract:

This invention relates to CD 19 binding agents and methods of using such CD 19 binding agents for treating disease.

US Patent:

7972992, Jul 5, 2011

Filed:

Dec 17, 2004

Appl. No.:

11/015458

Inventors:

Barry Morgan - Franklin MA, US
Stephen Hale - Belmont MA, US
Christopher C. Arico-Muendel - West Roxbury MA, US
Matthew Clark - Cambridge MA, US
Richard Wagner - Cambridge MA, US
David I. Israel - Concord MA, US
Malcolm L. Gefter - Lincoln MA, US
Dennis Benjamin - Redmond WA, US
Nils Jakob Vest Hansen - San Francisco CA, US
Malcolm J. Kavarana - Burlington MA, US
Steffen Phillip Creaser - Cambridge MA, US
George J. Franklin - Auburn MA, US
Paolo A. Centrella - Acton MA, US
Raksha A. Acharya - Bedford MA, US

Assignee:

Praecis Pharmaceuticals, Inc. - Waltham MA

International Classification:

C40B 50/00

US Classification:

506 23, 506 7, 506 13, 435 6

Abstract:

The present invention provides methods of synthesizing a molecule comprising a functional moiety which is operatively linked to an encoding oligonucleotide. The methods include providing an initiator compound comprising an initial functional moiety comprising n building blocks, wherein the initial functional moiety comprises at least one reactive group, and is operatively linked to an initial oligonucleotide; reacting the initiator compound with a building block comprising at least one complementary reactive group, under conditions suitable for reaction of the complementary reactive group to form a covalent bond; and reacting the initial oligonucleotide with an incoming oligonucleotide corresponding to the building block in the presence of an enzyme which catalyzes ligation of the initial oligonucleotide and the incoming oligonucleotide, under conditions suitable for ligation of the incoming oligonucleotide and the initial oligonucleotide to form an encoding oligonucleotide.

US Patent:

7972994, Jul 5, 2011

Filed:

Jun 9, 2006

Appl. No.:

11/450938

Inventors:

Barry Morgan - Franklin MA, US
Stephen Hale - Belmont MA, US
Christopher C. Arico-Muendel - West Roxbury MA, US
Matthew Clark - Cambridge MA, US
Richard Wagner - Cambridge MA, US
David I. Israel - Concord MA, US
Malcolm L. Gefter - Lincoln MA, US
Dennis Benjamin - Redmond WA, US
Nils Jakob Vest Hansen - Copenhagen V, DK
Malcolm J. Kavarana - Burlington MA, US
Steffen Phillip Creaser - Cambridge MA, US
George J. Franklin - Auburn MA, US
Paulo A. Centrella - Acton MA, US
Raksha A. Acharya - Bedford MA, US

Assignee:

GlaxoSmithKline LLC - Philadelphia PA

International Classification:

C40B 50/16

US Classification:

506 31, 506 7, 506 13, 506 23, 506 25, 506 30, 435 6, 435 912, 536 231, 530300, 530350

Abstract:

The present invention provides methods of synthesizing libraries of molecules comprising a functional moiety which is operatively linked to an encoding oligonucleotide, wherein the encoding oligonucleotide comprises a capping sequence containing degenerate nucleotides. The methods generally include providing a solution comprising initiator compounds comprising an initial functional moiety comprising n building blocks which is operatively linked to an initial oligonucleotide; dividing the solution into reaction vessels; reacting the initiator compounds in each reaction vessel with a building block comprising a complementary reactive group to form a covalent bond; and reacting the initial oligonucleotide in each aliquot with a distinct incoming oligonucleotide in the presence of an enzyme which catalyzes the ligation of the incoming oligonucleotide and the initial oligonucleotide, under conditions suitable for enzymatic ligation of the incoming oligonucleotide and the initial oligonucleotide to form an encoding oligonucleotide.

US Patent:

7989395, Aug 2, 2011

Filed:

Oct 23, 2006

Appl. No.:

11/584880

Inventors:

Barry Morgan - Franklin MA, US
Stephen Hale - Belmont MA, US
Christopher C. Arico-Muendel - West Roxbury MA, US
Matthew Clark - Bedford MA, US
Richard Wagner - Cambridge MA, US
David I. Israel - Concord MA, US
Malcolm L. Gefter - Lincoln MA, US
Dennis Benjamin - Redmond WA, US
Nils Jakob Vest Hansen - Copenhagen V, DK
Malcolm J. Kavarana - Burlington MA, US
Steffen Phillip Creaser - Cambridge MA, US
George J. Franklin - Lynn MA, US
Paolo A. Centrella - Acton MA, US
Raksha A. Acharya - Bedford MA, US

Assignee:

GlaxoSmithKline LLC - Philadelphia PA

International Classification:

C40B 50/16

US Classification:

506 31, 506 23, 506 16, 506 5, 435 6, 435 912, 536 231, 536 242

Abstract:

The present invention provides a method for identifying a compound of interest by screening libraries of molecules which include an encoding oligonucleotide tag.

US Patent:

8163551, Apr 24, 2012

Filed:

May 1, 2009

Appl. No.:

12/434533

Inventors:

Stephen C. Alley - Bothell WA, US
Scott C. Jeffrey - Bothell WA, US
Django Sussman - Bothell WA, US
Dennis R. Benjamin - Bothell WA, US
Brian Toki - Bothell WA, US
Patrick J. Burke - Bothell WA, US

Assignee:

Seattle Genetics, Inc. - Bothell WA

International Classification:

C12N 5/06
C12N 5/00
C07K 16/00

US Classification:

435326, 5303871, 435375, 435405

Abstract:

The invention provides methods and compositions for preparing antibodies and antibody derivatives with reduced core fucosylation.

US Patent:

8242252, Aug 14, 2012

Filed:

May 17, 2011

Appl. No.:

13/109957

Inventors:

Charlotte McDonagh - Waltham MA, US
Charles G. Cerveny - Seattle WA, US
Dennis Benjamin - Redmond WA, US
Paul Carter - Mercer Island WA, US
Hans Peter Gerber - Bellevue WA, US
Leigh Francisco - Woodway WA, US

Assignee:

Seattle Genetics, Inc. - Bothell WA

International Classification:

C07H 21/04

US Classification:

536 2353

Abstract:

This invention relates to CD 19 binding agents and methods of using such CD 19 binding agents for treating disease.

US Patent:

8309093, Nov 13, 2012

Filed:

Mar 5, 2010

Appl. No.:

12/718902

Inventors:

Jean Gudas - Los Angeles CA, US
Aya Jakobovits - Beverly Hills CA, US
Zili An - Santa Monica CA, US
Robert Kendall Morrison - Santa Monica CA, US
Karen Jane Meyrick Morrison - Santa Monica CA, US
Xiao-chi Jia - Los Angeles CA, US
Dennis Benjamin - Redmond WA, US
Ruth Moser - Bellevue WA, US
Peter Senter - Seattle WA, US

Assignee:

Agensys, Inc. - Santa Monica CA

International Classification:

A61K 39/395

US Classification:

4241781, 4241331

Abstract:

Antibody drug conjugates (ADC's) that bind to 24P4C12 protein and variants thereof are described herein. 24P4C12 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, the ADC's of the invention provide a therapeutic composition for the treatment of cancer.

US Patent:

8410028, Apr 2, 2013

Filed:

Mar 18, 2011

Appl. No.:

13/051314

Inventors:

Barry Morgan - Franklin MA, US
Stephen Hale - Belmont MA, US
Christopher C. Arico-Muendel - West Roxbury MA, US
Matthew Clark - Cambridge MA, US
Richard Wagner - Cambridge MA, US
David I. Israel - Concord MA, US
Malcolm L. Gefter - Lincoln MA, US
Dennis Benjamin - Redmond WA, US
Nils Jakob Vest Hansen - Copenhagen V, DK
Malcolm J. Kavarana - Fairfax VA, US
Steffan Phillip Creaser - Cambridge MA, US
George J. Franklin - Auburn MA, US
Paolo A. Centrella - Acton MA, US
Raksha A. Acharya - Bedford WA, US

Assignee:

GlaxoSmithKline LLC - Philadelphia PA

International Classification:

C40B 50/08
C40B 50/06
C40B 50/10

US Classification:

506 27, 506 26, 506 28

Abstract:

The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag.