Dhavalkumar S Patel

US Patent:

7033593, Apr 25, 2006

Filed:

Sep 17, 2003

Appl. No.:

10/664029

Inventors:

Barton F. Haynes - Durham NC, US
Dhavalkumar D. Patel - Durham NC, US
Munir Alam - Chapel Hill NC, US

Assignee:

Duke University - Durham NC

International Classification:

A61K 39/00

US Classification:

4241921, 4241851, 4241881, 4241931, 4241941, 4242081, 530324, 530325, 530326, 530327, 53038835, 5303894, 5303911, 530826

Abstract:

The invention relates to an immunogen comprising an HIV envelope protein bound to a ligand, which ligand upregulates at least one of the CD4 binding site and the CCR5 binding site on the protein, and bound to an HR-2 peptide. The invention also relates to a method of inducing anti-HIV antibodies using such an immunogen.

US Patent:

7041294, May 9, 2006

Filed:

Jun 5, 2001

Appl. No.:

09/874103

Inventors:

Herman F. Staats - Durham NC, US
Barton F. Haynes - Durham NC, US
Dhavalkumar D. Patel - Durham NC, US
Gregory D. Sempowski - Durham NC, US

Assignee:

Duke University - Durham NC

International Classification:

A61K 39/00
A61K 39/38
A61K 45/00
A61K 47/00
A61K 25/00

US Classification:

4241841, 424 852, 4241981, 4242781, 514885

Abstract:

A method of eliciting an immune response against an antigen in a vertebrate subject, the method comprising the steps of providing an antigen-adjuvant composition comprising the antigen and a substantially non-toxic adjuvant molecule having biological activity in mucosal tissues, and administering said antigen-adjuvant composition to the vertebrate subject in a manner such that initial contact occurs in mucosal tissue of the vertebrate subject, whereby an immune response is elicited. Cytokines are preferred adjuvants. Preferred cytokines are interleukin-1α(IL-1α) and interleukin-1β (IL-1β).

US Patent:

7070787, Jul 4, 2006

Filed:

Aug 25, 2003

Appl. No.:

10/646729

Inventors:

Barton F. Haynes - Durham NC, US
Dhavalkumar D. Patel - Durham NC, US
Munir Alam - Chapel Hill NC, US

Assignee:

Duke University - Durham NC

International Classification:

A61K 39/385

US Classification:

42419611, 4241881, 4241921, 4241931, 4242081

Abstract:

The present invention relates, in general, to an immunogen and, in particular, to an immunogen for inducing antibodies that neutralize a wide spectrum of HIV primary isolates. The invention also relates to a method of inducing anti-HIV antibodies using same.

US Patent:

7101552, Sep 5, 2006

Filed:

Sep 24, 2001

Appl. No.:

09/960717

Inventors:

Barton F. Haynes - Durham NC, US
Dhavalkumar D. Patel - Durham NC, US
Munir Alam - Chapel Hill NC, US

Assignee:

Duke University - Durham NC

International Classification:

A61K 39/395

US Classification:

4241781, 42419611, 4242081, 530350, 530826

Abstract:

The present invention relates, in general, to an immunogen and, in particular, to an immunogen for inducing antibodies that neutralize a wide spectrum of HIV primary isolates. The invention also relates to a method of inducing anti-HIV antibodies using same.

US Patent:

20020052318, May 2, 2002

Filed:

Aug 27, 2001

Appl. No.:

09/938831

Inventors:

Barton Haynes - Durham NC, US
Dhavalkumar Patel - Durham NC, US

Assignee:

DUKE UNIVERSITY

International Classification:

A61K048/00
A61K038/17

US Classification:

514/012000, 514/044000, 514/008000, 514/054000

Abstract:

The present invention relates, in general, to an adjuvant and, in particular, to an adjuvant that induces durable systemic and mucosal humoral, Th and/or CTL responses. The invention further relates to a composition, e.g., an immunogenic composition, comprising an immunogen and the adjuvant of the invention, and to a method of enhancing an immune response to an immunogen or immunogens using such an adjuvant.

US Patent:

20060204986, Sep 14, 2006

Filed:

Feb 14, 2006

Appl. No.:

11/353025

Inventors:

Barton Haynes - Durham NC, US
Dhavalkumar Patel - Chapel Hill NC, US
Munir Alam - Chapel Hill NC, US

Assignee:

DUKE UNIVERSITY - Durham NC

International Classification:

C12Q 1/70
C12Q 1/68

US Classification:

435006000, 435005000

Abstract:

The present invention relates, in general, to an immunogen and, in particular, to an immunogen for inducing antibodies that neutralize a wide spectrum of HIV primary isolates. The invention also relates to a method of inducing anti-HIV antibodies using same.

US Patent:

20080213296, Sep 4, 2008

Filed:

Sep 14, 2004

Appl. No.:

10/572312

Inventors:

Barton F. Haynes - Durham NC, US
Dhavalkumar D. Patel - Chapel Hill NC, US
Munir Alam - Chaple Hill NC, US

Assignee:

DUKE UNIVERSITY - Durham NC

International Classification:

A61K 39/385
C07K 14/00
C07K 16/00

US Classification:

4241931, 530395, 5303917

Abstract:

The present invention relates, in general, to an immunogen for inducing antibodies that neutralize a wide spectrum of HIV primary isolates. The invention also relates to a method of inducing anti-HIV antibodies using same.

US Patent:

57234370, Mar 3, 1998

Filed:

Nov 2, 1994

Appl. No.:

8/333350

Inventors:

Barton F. Haynes - Durham NC
Alejandro Aruffo - Edmonds WA
Dhavalkumar Patel - Durham NC

Assignee:

Duke University - Durham NC
Bristol-Myers Squibb Company - New York NY

International Classification:

A61K 3817
C07K 14435

US Classification:

514 2

Abstract:

The present invention relates, in general, to CD6 and, in particular, to a CD6 ligand present on the surface of thymic epithelial cells, monocytes, activated T cells and a variety of other cells types. The invention further relates to methods of inhibiting the interaction of CD6 and the CD6 ligand, and to the methods of screening componunds for their ability to inhibit that interaction.