Mel Kronick - Palo Alto CA, US Bernett Saunders - Portland OR, US Matthew Marton - Seattle WA, US John Hinchcliffe - Seattle WA, US Dianne Rees - Sunnyvale CA, US Carol Schembri - San Mateo CA, US
International Classification:
C12Q 1/68 G01N 33/53 G06F 19/00 C12M 1/34
US Classification:
435006000, 435007100, 702019000, 435287200
Abstract:
Methods and devices are disclosed for microarray analysis. In one embodiment a method is disclosed for processing a non-standard size slide having an array of chemical compounds attached to a surface of the slide. A sample is exposed to the surface of the non-standard size slide wherein components in the sample bind to the chemical compounds on the surface of the slide. The sample and the slide are incubated under conditions for carrying out the binding reactions, and the surface of the non-standard size slide is examined for the results of the binding reactions. Prior to the exposing step or the incubating step or the examining step, the non-standard size slide is placed into a slide holder comprising a slide-holding section a slide-holding section adapted to dispose the non-standard size slide to a processing instrument in a manner similar to that for a standard size slide. The non-standard size slide may also include an identifier such as a bar code.
Comparative Genome Hybridization Of Organelle Genomes
A comparative genome hybridization method is provided. In certain embodiments, the method comprises: a) contacting a first array of surface-bound nucleic acid probes with: i) a first labeled population of target nucleic acids from a genome of an organelle of a first cell; and ii) a second labeled population of target nucleic acids from a genome of an organelle of a second cell; and b) detecting binding between said surface-bound nucleic acid probes and the first and second labeled populations of target nucleic acids. Compositions for use in the subject methods are also provided.
A nucleic acid array is provided, as well as methods of using the same. In certain embodiments, the nucleic acid array comprises: a) a substrate; and b) an array of features on a surface of the substrate, where the features comprise interfering RNA molecules that are linked to the surface of the substrate by a cleavable linker.
Manufacture And Use Of Non-Standard Size Microarray Slides
Mel N. Kronick - Palo Alto CA, US Barnett E. Saunders - Portland OR, US Matthew J. Marton - Seattle WA, US John S. Hinchcliffe - Seattle WA, US Dianne Rees - Sunnyvale CA, US Carol T. Schembri - San Mateo CA, US
International Classification:
C40B 30/04 C40B 50/14 C40B 40/00
US Classification:
506 9, 506 30, 506 13
Abstract:
Methods and devices are disclosed for microarray analysis. In one embodiment a method is disclosed for processing a non-standard size slide having an array of chemical compounds attached to a surface of the slide. A sample is exposed to the surface of the non-standard size slide wherein components in the sample bind to the chemical compounds on the surface of the slide. The sample and the slide are incubated under conditions for carrying out the binding reactions, and the surface of the non-standard size slide is examined for the results of the binding reactions. Prior to the exposing step or the incubating step or the examining step, the non-standard size slide is placed into a slide holder comprising a slide-holding section a slide-holding section adapted to dispose the non-standard size slide to a processing instrument in a manner similar to that for a standard size slide. The non-standard size slide may also include an identifier such as a bar code.