Donald E Combs

US Patent:

56841515, Nov 4, 1997

Filed:

Mar 6, 1995

Appl. No.:

8/362476

Inventors:

Donald W. Combs - Piscataway NJ

Assignee:

Ortho Pharmaceutical Corporation - Raritan NJ

International Classification:

C07D23704
C07D40904
C07D23726

US Classification:

544224

Abstract:

Disclosed are progestin agonists having the following formula: ##STR1## W is absent or --CH. dbd. CH--; R. sup. 1 are independently selected from the group consisting of halogen, --CF. sub. 3, and NO. sub. 2, or both R. sup. 1 may be joined to form a bi-radical which is --CH. dbd. CHCH. dbd. CH--; R. sup. 3 are independently selected from the group consisting of hydrogen, C. sub. 1-6 branched or linear alkyl, halogen and --CF. sub. 3, with the proviso that R. sup. 3 at the 3-position must be H where R. sup. 3 at the 4-position is H, or both R. sup. 3 may be joined to form a bi-radical selected from the group consisting of --CH. dbd. CHCH. dbd. CH--, --C(NC. sub. 1-4 alkyl. sub. 2)=CHCH. dbd. CH-- and --(CH. sub. 2). sub. 4 --; R. sup.

US Patent:

53267656, Jul 5, 1994

Filed:

Nov 6, 1991

Appl. No.:

7/789379

Inventors:

Donald W. Combs - Piscataway NJ
Robert Falotico - Belle Mead NJ
Victor Bandurco - Bridgewater NJ

Assignee:

Ortho Pharmaceutical Corporation - Raritan NJ

International Classification:

A61K 31505
C07D40304

US Classification:

514259

Abstract:

Novel 2,2,4-trialkyl-1,2-dihydroquinazoline-3-oxides and their synthesis are described. These compounds possess cardiotonic activity, and are useful for the treatment of heart failure.

US Patent:

50306359, Jul 9, 1991

Filed:

Aug 8, 1990

Appl. No.:

7/564906

Inventors:

Donald W. Combs - Piscataway NJ
Robert Falotico - Belle Mead NJ
David M. Ritchie - Princeton Junction NJ

Assignee:

Ortho Pharmaceutical Corporation - Raritan NJ

International Classification:

A61K 31505
C07D40304

US Classification:

514259

Abstract:

Novel 6,7-dimethoxy-1,2-dihydro-2-arylquinazoline-3-oxides and their synthesis are described. These novel compounds are cardiotonic agents and bronchodilating agents, and as such are useful for the treatment of heart failure and asthma.

US Patent:

49635549, Oct 16, 1990

Filed:

Feb 14, 1990

Appl. No.:

7/479796

Inventors:

Donald W. Combs - Piscataway NJ
Robert Falotico - Belle Mead NJ
David M. Ritchie - Princeton Junction NJ

Assignee:

Ortho Pharmaceutical Corporation - Raritan NJ

International Classification:

A61K 31505
C07D40304

US Classification:

514259

Abstract:

Novel 6,7-dimethoxy-1,2-dihydro-2-arylquinazoline-3-oxides and their synthesis are described. These novel compounds are cardiotonic agents and bronchodilating agents, and as such are useful for the treatment of heart failure and asthma.

US Patent:

51168375, May 26, 1992

Filed:

Dec 21, 1990

Appl. No.:

7/631560

Inventors:

Donald W. Combs - Piscataway NJ

Assignee:

Ortho Pharmaceutical Corporation - Paritan NJ

International Classification:

C07D49804
A61K 31535

US Classification:

5142298

Abstract:

The invention relates to novel compounds, 2,9-dihydro(6 or 7)-3-oxo-2,3,4,5-tetrahydropyridazinyl)pyrazolo[4,3-b]benzoxazines. The claimed compounds are inhibitors of phosphodiesterase fraction III and have potent positive inotropic activity. These compounds are useful as cardiotonics or platelet aggregation inhibitors. This invention also pertains to compositions comprising an effective amount of the compounds, to methods for preparing the claimed compounds and to methods for treating a mammal with the compounds.

US Patent:

47451181, May 17, 1988

Filed:

Jun 5, 1986

Appl. No.:

6/871031

Inventors:

Donald W. Combs - Piscataway NJ
Robert Falotico - Belle Mead NJ

Assignee:

Ortho Pharmaceutical Corporation - Raritan NJ

International Classification:

A61K 3100
C07D41300

US Classification:

514259

Abstract:

Novel substituted quinazoline-3-oxides are disclosed as are methods of increasing cardiotonic activity and bronchodilation in which an unit dose of a composition containing an effective amount of a cardiotonic agent or a bronchodilating agent dispersed in a pharmaceutically acceptable carrier are administered to a mammalian host.

US Patent:

47217847, Jan 26, 1988

Filed:

Dec 22, 1986

Appl. No.:

6/944316

Inventors:

Donald W. Combs - Piscataway NJ

Assignee:

Ortho Pharmaceutical Corporation - Raritan NJ

International Classification:

C07D41304

US Classification:

544105

Abstract:

The synthesis of benzoxazinyl-pyridazinone compounds is described. The novel compounds are cardiotonic agents and inhibitors of phosphodiesterase fraction III. In addition, the compounds are useful as smooth muscle relaxants and bronchodilators.

US Patent:

47661186, Aug 23, 1988

Filed:

Jun 22, 1987

Appl. No.:

7/064638

Inventors:

Donald W. Combs - Piscataway NJ

Assignee:

Ortho Pharmaceutical Corporation - Raritan NJ

International Classification:

A61K 31535
A61K 3154
C07D41304
C07D41704

US Classification:

5142242

Abstract:

The synthesis of benzoxazinyl- and benzothiazinylpyridazinone compounds is described. The novel compounds are cardiotonic agents and inhibitors of phosphodiesterase. In addition, the compounds are useful as smooth muscle relaxants and bronchodilators.

Address:

7411 Kyles Sta Rd, Liberty Township, OH 45044

VIN:

1FTRF12237KB92619

Make:

FORD

Model:

F-150

Year:

2007