Donald R Cook

US Patent:

6427063, Jul 30, 2002

Filed:

Nov 22, 1999

Appl. No.:

09/424353

Inventors:

Donald A. Cook - Jamaica Plain MA
George Lukas - Brighton MA
Andrew V. Lukas - Boulder CO
David J. Padwa - Santa Fe NM

Assignee:

Finali Corporation - Westminster CO

International Classification:

G09B 300

US Classification:

434350, 434118, 434336, 434322, 706927

Abstract:

This invention relates to a system and method for interactive, adaptive, and individualized computer assisted instruction. This invention includes an agent ( ) for each student ( ) which adapts to its student, and provides individualized guidance to the student and controls to the augmented computer assisted instructional materials. The instructional materials of this invention are augmented to communicate the students performance and the materials pedagogical characteristics to the agent, and to receive control from the agent. In a preferred embodiment, the agent maintains data reflecting the students pedagogic or cognitive characteristics in a protected and portable media in the personal control of the student. Preferably, the content of the communication between the agent and the materials conforms to specified interface standards, so that the agent acts independently of the content of the particular materials. Also preferably, the agent can project using various I/O modalities integrated engaging, lifelike display personna(e).

US Patent:

6606479, Aug 12, 2003

Filed:

Feb 14, 2002

Appl. No.:

10/075889

Inventors:

Donald A. Cook - Jamaica Plain MA
George Lukas - Brighton MA
Andrew V. Lukas - Boulder CO
David J. Padwa - Santa Fe NM

Assignee:

Finali Corporation - Westminster CO

International Classification:

G09B 300

US Classification:

434350, 434118, 434322, 434362, 434336, 706927

Abstract:

This invention relates to a system and method for interactive, adaptive, and individualized computer assisted instruction. This invention includes an agent ( ) for each student ( ) which adapts to its student, and provides individualized guidance to the student and controls to the augmented computer assisted instructional materials. The instructional materials of this invention are augmented to communicate the students performance and the materials pedagogical characteristics to the agent, and to receive control from the agent. In a preferred embodiment, the agent maintains data reflecting the students pedagogic or cognitive characteristics in a protected and portable media in the personal control of the student. Preferably, the content of the communication between the agent and the materials conforms to specified interface standards, so that the agent acts independently of the content of the particular materials. Also preferably, the agent can project using various I/O modalities integrated engaging, lifelike display personna(e).

US Patent:

20090054411, Feb 26, 2009

Filed:

Oct 13, 2008

Appl. No.:

12/250314

Inventors:

Donald Cook - Waltham MA, US
Leslie Dakin - Waltham MA, US
David Del Valle - Austin TX, US
Thomas Gero - Waltham MA, US
David Scott - Waltham MA, US
Xiaolan Zheng - Waltham MA, US

Assignee:

AstraZeneca AB - Sodertalje

International Classification:

A61K 31/496
C07D 401/04
A61K 31/5377
A61P 35/00
A61K 31/551
C07D 413/04

US Classification:

514218, 544363, 544128, 540575, 51425306, 5142352

Abstract:

The invention relates to chemical compounds of formula IA or IB:or pharmaceutically acceptable salts thereof which possess CSF-1R kinase inhibitory activity and are accordingly useful for their anti-cancer activity and thus in methods of treatment of the human or animal body. The invention also relates to processes for the manufacture of said chemical compounds, to pharmaceutical compositions containing them and to their use in the manufacture of medicaments of use in the production of an anti-cancer effect in a warm-blooded animal such as man.

US Patent:

20100216791, Aug 26, 2010

Filed:

Aug 15, 2007

Appl. No.:

12/377285

Inventors:

Brian Aquila - Waltham MA, US
Donald J. Cook - Waltham MA, US
Craig Johnstone - Macclesfield, GB
Stephen Lee - Waltham MA, US
Paul Lyne - Waltham MA, US
David Alan Rudge - Macclesfield, GB
Melissa Vasbinder - Waltham MA, US
Haixia Wang - Waltham MA, US

Assignee:

ASTRAZENECA - Södertälje

International Classification:

A61K 31/5377
C07D 401/04
A61K 31/517
A61P 35/00
A61P 35/02
C07D 413/14

US Classification:

5142345, 544284, 51426621, 544119

Abstract:

The invention relates to chemical compounds of the formula (I) or pharmaceutically acceptable salts thereof, which possess B-Raf inhibitory activity and are accordingly useful for their anti cancer activity and thus in methods of treatment of the human or animal body. The invention also relates to processes for the manufacture of said chemical compounds, to pharmaceutical compositions containing them and to their use in the manufacture of medicaments of use in the production of an anti-cancer effect in a warm blooded animal such as man.