David Flyer - Olney MD, US Mark Ross - Charlottesville VA, US Donald Hunt - Charlottesville VA, US Forest White - Charlottesville VA, US Victor Engelhard - Charlottesville VA, US Ramila Philip - Charlottesville VA, US
International Classification:
A61K039/00 C07K007/08 C07K007/06
US Classification:
424/185100, 530/328000, 530/327000
Abstract:
The present invention relates to compositions and methods for the prevention, treatment, and diagnosis of tuberculosis, and discloses peptides, polypeptides, and polynucleotides that can be used to stimulate a CTL response against tuberculosis. The peptide and/or proteins of the invention may be used as a therapeutic drug to stimulate the immune system to recognize and eliminate in infected cells or as a vaccine for the prevention of disease. Antibodies that react with the immunogens of the invention, as well as methods of using these antibodies for prevention and treatment of disease, are also disclosed.
Suzanne L. Topalian - Brookeville MD, US Florence Depontieu - Lyon, FR Donald Hunt - Charlottesville VA, US Jeffrey Shabanowitz - Charlottesville VA, US Jie Qian - Bridgewater NJ, US Victor Engelhard - Crozet VA, US Angela Zaring - charlottesviille VA, US
Assignee:
UNIVERSITY OF VIRGINIA PATENT FOUNDATION - Charlottesville VA THE JOHNS HOPKINS UNIVERSITY - Baltimore MD
We characterized a total of 175 HLA-DR-associated phosphopeptides using sequential affinity isolation, biochemical enrichment, mass spectrometric sequencing and comparative analysis. Many were derived from source proteins which may have roles in cancer development, growth and metastasis. Most were expressed exclusively by either melanomas or transformed B cells, suggesting the potential to define cell type-specific phosphatome “fingerprints”. We generated HLA-DRβ1*0101-restricted CD4T cells specific for a phospho-MART-1 peptide identified in two melanoma cell lines. These T cells showed specificity for phosphopeptide-pulsed antigen presenting cells as well as for intact melanoma cells. MHC II-restricted phosphopeptides recognizable by human CD4T cells are potential targets for cancer immunotherapy.
Donald Hunt Plumbing Inc Construction · Plumbing/Heating/Air Cond Contractor · Gas Leak Repair · Plumbing · Remodeling · Water Damage Restoration · Water Heaters
12009 Falling Crk Dr, Manassas, VA 20112 (703)7949357
U.S. Securities and Exchange Commission 100 F Street, N.e., Washington, DC 20549
Licenses:
California - Active 1999
Experience:
Attorney at U.S. Securities & Exchange Commission - 2004-present Attorney at Morrison & Foerster - 1999-2004 Attorney at Cadwalader, Wickersham & Taft - 1998-1999
Education:
Catholic University of America, School of Law Degree - JD - Juris Doctor - Law Graduated - 1998 Middlebury College Degree - BA - Bachelor of Arts - Economics Graduated - 1992
SVP Human Resources at Mid Missouri Credit Union, Adjunct Faculty at Webster University
Location:
Waynesville, Missouri
Industry:
Financial Services
Work:
Mid Missouri Credit Union since Jan 2011
SVP Human Resources
Webster University since 2003
Adjunct Faculty
United States Air Force 1982 - 2003
Accountant/First Sergeant
Education:
Troy University 2000 - 2002
MSM, Management
Indiana Wesleyan University 1990 - 1992
BSBA, Business Administration and Management, General
Sportswriter at The Philadelphia Tribune Donald Hunt covers high school, college and professional sports for The Philadelphia Tribune. He has written five books including The Philadelphia Big 5, Great... Donald Hunt covers high school, college and professional sports for The Philadelphia Tribune. He has written five books including The Philadelphia Big 5, Great Names in Black College Sports and Chaney:Playing for a Legend, which profiles Hall of Fame coach John Chaney with former Temple stars Aaron...
Delton Elementary School Edmonton Azores 1946-1951, Highlands Junior High School Edmonton Azores 1950-1953, Queen Elizabeth Junior High School Calgary Azores 1954-1957