Donald W Orr

US Patent:

8551724, Oct 8, 2013

Filed:

Jun 7, 2011

Appl. No.:

13/154719

Inventors:

Douglas M. Webel - Noblesville IN, US
Donald E. Orr - Noblesville IN, US
Frank E. Ruch - Falmouth ME, US
Xingen Lei - Ithaca NY, US

Assignee:

Huvepharma AD - Sofia
Cornell Research Foundation, Inc. - Ithaca NY

International Classification:

C12Q 1/48
C12N 9/16

US Classification:

435 15, 435196

Abstract:

A method is described for improving the nutritional value of a foodstuff comprising a source of myo-inositol hexakisphosphate by feeding the foodstuff in combination with a phytase expressed in yeast. The method comprises the step of feeding the animal the foodstuff in combination with a phytase expressed in yeast wherein the phytase can be selected from the group consisting of AppA1, AppA2 and a site-directed mutant of AppA. The invention also enables reduction of the feed to weight gain ratio and an increase bone mass and mineral content of an animal. A foodstuff and a feed additive comprising AppA2 or a site-directed mutant of AppA are also described.

US Patent:

20030206913, Nov 6, 2003

Filed:

Oct 31, 2002

Appl. No.:

10/284962

Inventors:

Douglas Webel - Noblesville IN, US
Donald Orr - Noblesville IN, US
Frank Ruch - Falmouth ME, US

International Classification:

A61K039/00
A61K039/38

US Classification:

424/184100

Abstract:

A method is described for improving the nutritional value of a foodstuff comprising a source of myo-inositol hexakisphosphate by feeding the foodstuff in combination with a phytase expressed in yeast. The method comprises the step of feeding the animal the foodstuff in combination with a phytase expressed in yeast wherein the phytase can be selected from the group consisting of AppA1, AppA2 and a site-directed mutant of AppA. The invention also enables reduction of the feed to weight gain ratio and an increase bone mass and mineral content of an animal. A foodstuff and a feed additive comprising AppA2 or a site-directed mutant of AppA are also described.