- Summit NJ, US John R. Coombs - New Brunswick NJ, US Keming Zhu - New Brunswick NJ, US Daniel Lim - Summit NJ, US Candice Lee Joe - New Brunswick NJ, US David T. George - New Brunswick NJ, US Bin Zheng - Kendall Park NJ, US Dong Lin - Monmouth Junction NJ, US
International Classification:
C07D 495/14 C07C 255/50 C07D 215/58 C07D 495/04
Abstract:
The present disclosure provides novel synthetic intermediates useful in the synthesis of MK2 kinase inhibitors.
Substituted 4-Amino-1H-Imidazo[4,5-C]Quinoline Compounds And Improved Methods For Their Preparation
- Princeton NJ, US Adrian Ortiz - Oak Park CA, US Rebecca A. Green - Metuchen NJ, US Christopher Robert Jamison - Hillsborough NJ, US Candice Lee Joe - Metuchen NJ, US Sergei Kolotuchin - Roselle Park NJ, US Eric M. Simmons - East Brunswick NJ, US Neil A. Strotman - Flemington NJ, US Matthew W. Haley - East Brunswick NJ, US Yichen Tan - East Brunswick NJ, US Andrew William Glace - Morrisville PA, US Dong Lin - Monmouth Junction NJ, US Albert J. DelMonte - Belle Mead NJ, US Peng Geng - Hillsborough NJ, US Bahar Inankur - New Brunswick NJ, US Victor W. Rosso - Monroe Township NJ, US Mansi S. Shah - Highland Park NJ, US
Improved methods and intermediates thereof for preparing substituted 4-amino-1H-imidazo[4,5-c]quinoline compounds are described. These compounds are useful as NLRP3 modulators.
Process For The Preparation Of 6-(Cyclopropaneamido)-4-((2-Methoxy-3-(1-Methyl-1H-1,2,4-Triazol-3-Yl)Phenyl)Amino)-N-(Methyl-D3)Pyridazine-3-Carboxamide
- Princeton NJ, US Joerg Deerberg - Columbus NJ, US Dong Lin - Monmouth Junction NJ, US Michael Dummeldinger - Plainsboro NJ, US Bahar Inankur - New Brunswick NJ, US Sergei Kolotuchin - Roselle Park NJ, US Jun Li - Langhorne PA, US Amanda J. Rogers - Asbury NJ, US Victor W. Rosso - Monroe Township NJ, US Eric M. Simmons - East Brunswick NJ, US Maxime C.D. Soumeillant - Princeton NJ, US Daniel S. Treitler - Cranford NJ, US Jianji Wang - Dayton NJ, US Bin Zheng - Kendall Park NJ, US Michael J. Smith - Somerset NJ, US Neil A. Strotman - Flemington NJ, US Steven Tymonko - Lindenhurst IL, US Tamas Benkovics - East Brunswick NJ, US
International Classification:
C07D 403/12 C07C 211/09 C07D 237/24 C07D 249/08
Abstract:
The invention relates to an improved process for synthesizing 6-(cyclopropaneamido)-4-((2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)amino)-N-(methyl-d3)pyridazine-3-carboxamide of the formula:Compound I is currently in clinical trials for the treatment of auto-immune and auto-inflammatory diseases such as psoriasis.
Process For The Preparation Of 6-(Cyclopropaneamido)-4-((2-Methoxy-3-(1-Methyl-1H-1,2,4-Triazol-3-Yl)Phenyl)Amino)-N-(Methyl-D3)Pyridazine-3-Carboxamide
- Princeton NJ, US Joerg Deerberg - Columbus NJ, US Dong Lin - Monmouth Junction NJ, US Michael Dummeldinger - Plainsboro NJ, US Bahar Inankur - New Brunswick NJ, US Sergei Kolotuchin - Roselle Park NJ, US Jun Li - Langhorne PA, US Amanda J. Rogers - Asbury NJ, US Victor W. Rosso - Monroe Township NJ, US Eric M. Simmons - East Brunswick NJ, US Maxime C.D. Soumeillant - Princeton NJ, US Daniel S. Treitler - Cranford NJ, US Jianji Wang - Dayton NJ, US Bin Zheng - Kendall Park NJ, US Michael J. Smith - Somerset NJ, US Neil A. Strotman - Flemington NJ, US Steven Tymonko - Lindenhurst IL, US Tamas Benkovics - East Brunswick NJ, US
International Classification:
C07D 403/12 C07D 249/08 C07C 211/09 C07D 237/24
Abstract:
The invention relates to an improved process for synthesizing 6-(cyclopropaneamido)-4-((2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)amino)-N-(methyl-d3)pyridazine-3-carboxamide of the formula: [INSERT CHEMICAL STRUCTURE HERE] Compound I is currently in clinical trials for the treatment of auto-immune and auto-inflammatory diseases such as psoriasis.
Kaiser Permanente Medical GroupKaiser Permanente South San Francisco Medical Center 1200 El Camino Real, South San Francisco, CA 94080 (650)7422000 (phone), (650)7422606 (fax)
Dong Lin MD 950 Stockton St STE 207, San Francisco, CA 94108 (415)3999646 (phone), (415)3990156 (fax)
Education:
Medical School Beijing Med Univ, Beijing City, Beijing, China Graduated: 1982
Procedures:
Destruction of Benign/Premalignant Skin Lesions Hearing Evaluation Vaccine Administration
Dr. Lin graduated from the Beijing Med Univ, Beijing City, Beijing, China in 1982. He works in San Francisco, CA and 1 other location and specializes in Pediatrics. Dr. Lin is affiliated with California Pacific Medical Center California Campus, Kaiser Permanente Medical Center and UCSF Medical Center Parnassus.