Yiyin Ku - Buffalo Grove IL, US Keith F. McDaniel - Wauconda IL, US Hui-Ju Chen - Grayslake IL, US Jason P. Shanley - Chicago IL, US Dale J. Kempf - Libertyville IL, US David J. Grampovnik - Waukegan IL, US Ying Sun - Waltham MA, US Dong Liu - Newton MA, US Yonghua Gai - North Grafton MA, US Yat Sun Or - Watertown MA, US Seble H. Wagaw - Evanston IL, US Ken Engstrom - Mundelein IL, US Tim Grieme - Chicago IL, US Ahmad Sheikh - Deerfield IL, US Jianzhang Mei - Lake Forest IL, US
International Classification:
A61K 38/12 C07D 487/04 A61P 31/12
US Classification:
514 11, 540460
Abstract:
The present invention relates to novel macrocyclic compounds and methods of treating a hepatitis C infection in a subject in need of such therapy with said macrocyclic compounds. The present invention further relates to pharmaceutical compositions comprising the compounds of the present invention, or pharmaceutically acceptable salts, esters, or prodrugs thereof, in combination with a pharmaceutically acceptable carrier or excipient.
Macrocyclic Hepatitis C Serine Protease Inhibitors
Yiyin Ku - Buffalo Grove IL, US Keith F. McDaniel - Wauconda IL, US Hui-Ju Chen - Grayslake IL, US Jason P. Shanley - Chicago IL, US Dale J. Kempf - Libertyville IL, US David J. Grampovnik - Waukegan IL, US Ying Sun - Waltham MA, US Dong Liu - Newton MA, US Yonghua Gai - North Grafton MA, US Yat Sun Or - Watertown MA, US Seble H. Wagaw - Evanston IL, US Ken Engstrom - Mundelein IL, US Tim Grieme - Chicago IL, US Ahmad Sheikh - Deerfield IL, US Jianzhang Mei - Lake Forest IL, US
Assignee:
ENANTA PHARMACEUTICALS, INC. - Watertown MA ABBOTT LABORATORIES - Abbott Park IL
International Classification:
A61K 38/12 A61P 31/12 C07K 5/12
US Classification:
514 37, 530317
Abstract:
The present invention relates to novel macrocyclic compounds and methods of treating a hepatitis C infection in a subject in need of such therapy with said macrocyclic compounds. The present invention further relates to pharmaceutical compositions comprising the compounds of the present invention, or pharmaceutically acceptable salts, esters, or prodrugs thereof, in combination with a pharmaceutically acceptable carrier or excipient.
Compositions And Methods For Nanoparticle Lyophile Forms
- Osaka, JP Yuwei Wang - Oceanside CA, US Haiqing Yin - San Marcos CA, US Liping Wang - Carlsbad CA, US Dong Liu - Irvine CA, US Wenbin Ying - San Diego CA, US
This invention provides compositions for making a solid lyophile of one or more nucleic acid active agents, which can be reconstituted as a drug product. The composition can include an aqueous suspension of lipid nanoparticles in a pharmaceutically acceptable solution, wherein the lipid nanoparticles encapsulate one or more nucleic acid active agents, a dextrin compound, and a saccharide compound. The nucleic acid active agents can be RNAi molecules capable of mediating RNA interference, as well as other RNAs and oligonucleotides.
Compositions And Methods For Nanoparticle Lyophile Forms
- Osaka, JP Yuwei Wang - Oceanside CA, US Haiqing Ying - San Marcos CA, US Liping Wang - Carlsbad CA, US Dong Liu - Irvine CA, US Wenbin Ying - San Diego CA, US
International Classification:
A61K 9/19 C12N 15/113 A61K 9/14
Abstract:
This invention provides compositions for making a solid lyophile of one or more nucleic acid active agents, which can be reconstituted as a drug product. The composition can include an aqueous suspension of lipid nanoparticles in a pharmaceutically acceptable solution, wherein the lipid nanoparticles encapsulate one or more nucleic acid active agents, a dextrin compound, and a saccharide compound. The nucleic acid active agents can be RNAi molecules capable of mediating RNA interference, as well as other RNAs and oligonucleotides.
Isbn (Books And Publications)
Ca Ca: Zang Chuan Fo Jiao Mo Zhi Ni Fo Xiang = Satsatsha = Tsha Tsha, Tibetan Clay Molded Buddhist Images
Apr 2013 to Aug 2013China Merchants Bank HeFei, CN Jan 2012 to Jun 2012 credit administratorInvestment Club
Feb 2011 to Dec 2011China Club
Jan 2009 to Dec 2011
Education:
University of Illinois at Chicago AACSB Accredited Chicago, IL Aug 2012 to Aug 2013 MBA in ManagementSaint Could State University AACSB Accredited Aug 2008 to Dec 2011 Bachelor of Science in Finance
as Fujian Strait Textile Technology Co. are switching their business models to target the home market. It used to sell 60% of its products to Europe and the U.S. before the coronavirus crisis wiped out those sales. Now, Dong Liu, the companys vice president, is looking for opportunities at home.