Dong S Wang

US Patent:

20050287114, Dec 29, 2005

Filed:

Jun 10, 2005

Appl. No.:

11/150865

Inventors:

Dong Wang - Omaha NE, US
Scott Miller - Salt Lake City UT, US
Pavla Kopeckova - Salt Lake City UT, US
Jindrich Kopecek - Salt Lake City UT, US

International Classification:

A61K038/08
A61K031/785
C07C237/26

US Classification:

424078270, 525054100, 525296000, 552205000, 514152000

Abstract:

The present invention provides bone-targeting polymeric drug delivery systems based on HPMA and related copolymers and methods of making thereof. The water-soluble bone-targeting polymeric conjugates of the present invention comprise water-soluble copolymer backbones (P) which are linked, via a first spacer (S), with a bone-related therapeutic agents or drug (D) and, via a second spacer (S), with a bone-targeting moiety (T).

US Patent:

20080159959, Jul 3, 2008

Filed:

Mar 30, 2005

Appl. No.:

10/591258

Inventors:

Dong Wang - Omaha NE, US
Jindrich Kopecek - Salt Lake City UT, US
Scott C. Miller - Salt Lake City UT, US
Pavla Kopeckova - Salt Lake City UT, US

Assignee:

University of Utah Research Foundation - Salt Lake City UT

International Classification:

A61K 47/48
A61K 47/30
A61K 38/02
A61K 31/44
A61K 38/13
A61K 33/34
A61K 49/12
A61P 29/00
A61K 49/00
A61K 33/24
A61K 31/197
A61K 31/519
A61K 47/38

US Classification:

424 93, 5147723, 514781, 514778, 514774, 514169, 514 2, 514249, 514352, 514562, 514 9, 424649, 424630, 424 91, 424 94

Abstract:

This invention relates to biotechnology, more particularly, to water-soluble polymeric delivery systems for the imaging, evaluation and/or treatment of rheumatoid arthritis and other inflammatory diseases. Using modern MR imaging techniques, the specific accumulation of macromolecules in arthritic joints in adjuvant-induced arthritis in rats is demonstrated. The strong correlation between the uptake and retention of the MR contrast agent labeled polymer with histopathological features of inflammation and local tissue damage demonstrates the practical applications of the macromolecular delivery system of the invention.

US Patent:

20090311182, Dec 17, 2009

Filed:

Jan 9, 2009

Appl. No.:

12/351417

Inventors:

Dong Wang - Omaha NE, US
Xinming Liu - Omaha NE, US

International Classification:

A61K 31/573
A61P 29/00
A61K 47/48
C07C 243/10
C07K 2/00
C08F 20/58
A61K 49/12

US Classification:

424 91, 5147724, 514180, 564148, 530300, 526304

Abstract:

This invention relates to biotechnology, more particularly, to water-soluble polymeric delivery systems for the imaging, evaluation and/or treatment of rheumatoid arthritis and other inflammatory diseases. Using modern MR imaging techniques, the specific accumulation of macromolecules in arthritic joints in adjuvant-induced arthritis in rats is demonstrated. The strong correlation between the uptake and retention of the MR contrast agent labeled polymer with histopathological features of inflammation and local tissue damage demonstrates the practical applications of the macromolecular delivery system of the invention.

US Patent:

20100022481, Jan 28, 2010

Filed:

Aug 11, 2009

Appl. No.:

12/539290

Inventors:

Dong Wang - Omaha NE, US
Christopher Hein - Omaha NE, US
Xin-Ming Liu - Omaha NE, US

International Classification:

A61K 47/26
C08B 37/16
A61P 19/08
A61K 31/6615

US Classification:

514108, 536103, 514778

Abstract:

Drug carriers, methods of synthesizing, and methods of use thereof are provided.

US Patent:

20100047258, Feb 25, 2010

Filed:

Aug 2, 2007

Appl. No.:

12/374387

Inventors:

Dong Wang - Omaha NE, US
Richard A. Reinhardt - Roca NE, US
Xin-Ming Liu - Omaha NE, US

International Classification:

A61K 39/395
C07K 16/00
C08B 37/16
A61K 31/724
A61P 37/06

US Classification:

4241781, 5303911, 536103, 514 58

Abstract:

Drug carriers, methods of synthesizing, and methods of use thereof are provided.

US Patent:

20110171144, Jul 14, 2011

Filed:

Jul 9, 2009

Appl. No.:

13/002538

Inventors:

Dong Wang - Omaha NE, US
Xue Li - Omaha NE, US
Xin-Ming Liu - Omaha NE, US
Richard A. Reinhardt - Roca NE, US

International Classification:

A61K 8/21
A61K 8/18
A61K 8/55
A61K 38/43
A61K 8/34
A61P 1/02
A61P 19/08

US Classification:

424 52, 424 49, 424 57, 424 941

Abstract:

Compositions and methods for targeting agents to hard tissue are provided comprising A method includes administering to a subject a composition compπsing micelles, the micelles compπsing at least one amphiphilic block copolymer linked to at least one tooth targeting moiety The composition further includes at least one encapsulated compound and is provided in a pharmaceutically acceptable carrier.

US Patent:

20120189543, Jul 26, 2012

Filed:

Sep 9, 2010

Appl. No.:

13/393104

Inventors:

Dong Wang - Omaha NE, US
Steven R. Goldring - New York NY, US
Edward V. Fehringer - Omaha NE, US

International Classification:

A61K 51/06
A61P 19/08
A61P 29/00
A61K 49/00
A61K 31/785

US Classification:

424 165, 424 91, 424 7818

Abstract:

Methods and compositions for detecting, diagnosing, and treating osteolysis and implant loosening are disclosed.

US Patent:

20130243696, Sep 19, 2013

Filed:

Nov 4, 2011

Appl. No.:

13/880829

Inventors:

Dong Wang - Omaha NE, US
Matthew Kelso - Papillion NE, US

Assignee:

Board of Regents of the University of Nebraska - Lincoln NE

International Classification:

A61K 47/48
A61K 49/00
A61K 45/06

US Classification:

424 91, 424 7817

Abstract:

Compositions and methods for the inhibition and/or prevention of traumatic brain injury and the symptoms associated with it are provided.

Address:

15532 Windsor Dr, Omaha, NE 68154

VIN:

1HGFA16537L093722

Make:

HONDA

Model:

CIVIC SDN

Year:

2007