Dongxuan D Shen

US Patent:

20060199241, Sep 7, 2006

Filed:

Nov 1, 2005

Appl. No.:

11/264288

Inventors:

Hyoungsik Yim - Ann Arbor MI, US
Mark Meyerhoff - Ann Arbor MI, US
Dongxuan Shen - Ann Arbor MI, US
Sangyeul Hwang - Ann Arbor MI, US

International Classification:

C12Q 1/37
C07K 14/47
C07K 14/80

US Classification:

435023000, 530350000, 530409000

Abstract:

A marker molecule for monitoring cleaving enzyme activity is disclosed. The marker molecule includes a protein, a peptide, or an oligonucleotide. A co-factor is conjugated to the protein, the peptide, or the oligonucleotide, thereby forming a co-factor labeled protein, a co-factor labeled peptide, or a co-factor labeled oligonucleotide. The co-factor is adapted to produce an enzymatic signal that is at least one of electrochemically and optically detectable.