Doris P Schumacher

US Patent:

6506767, Jan 14, 2003

Filed:

Jul 1, 1998

Appl. No.:

09/108689

Inventors:

Doris P. Schumacher - Bedminster NJ
Junning Lee - Gillette NJ
Lawrence R. Rogers - Short Hills NJ
Charles G. Eckhart - Scotch Plains NJ
Naneshwar S. Sawant - Edison NJ
Michael B. Mitchell - Basking Ridge NJ

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

C07D40108

US Classification:

514290, 546 93

Abstract:

Crystalline polymorphs of 8-chloro-6,11-dihydro-11-(4-piperidylidene)-5H-benzo[5,6]cycloheptic[1,2-b]pyridine represented by the formula pharmaceutical compositions containing such polymorphs, and methods of using such polymorphs to treat allergic reactions in mammals such as man are disclosed.

US Patent:

6875866, Apr 5, 2005

Filed:

Feb 19, 2003

Appl. No.:

10/368973

Inventors:

Vilas H. Dahanukar - Edison NJ, US
Jeffrey M. Eckert - Hazlet NJ, US
Dinesh Gala - East Brunswick NJ, US
Brian Lucas - Madison WI, US
Doris P. Schumacher - Bedminster NJ, US
Ilia Zavialov - East Windsor NJ, US

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

C07D223/14

US Classification:

540576

Abstract:

In one embodiment, the present invention describes the synthesis of a compound of formula and intermediates therefor.

US Patent:

7071342, Jul 4, 2006

Filed:

Apr 16, 2004

Appl. No.:

10/826456

Inventors:

Jianguo Yin - Edison NJ, US
Xiaoyong Fu - Edison NJ, US
Shuyi Zhang - Parsippany NJ, US
Timothy L. McAllister - Westfield NJ, US
Jason L. Winters - East Windsor NJ, US
Anantha Sudhakar - East Brunswick NJ, US
Doris P. Schumacher - Bedminster NJ, US

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

C07D 307/54

US Classification:

549494

Abstract:

Disclosed is a process for making the compound of formula I:.

US Patent:

7462740, Dec 9, 2008

Filed:

May 9, 2006

Appl. No.:

11/430687

Inventors:

Jianguo Yin - Edison NJ, US
Xiaoyong Fu - Edison NJ, US
Shuyi Zhang - Parsipanny NJ, US
Timothy L. McAllister - Westfield NJ, US
Jason L. Winters - East Windsor NJ, US
Anantha Sudhakar - East Brunswick NJ, US
Doris P. Schumacher - Bedminster NJ, US

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

C07C 231/02
C07C 233/65

US Classification:

564139, 564167

Abstract:

Disclosed is a process for making the compound of formula I:.

US Patent:

7910775, Mar 22, 2011

Filed:

Oct 17, 2008

Appl. No.:

12/253356

Inventors:

Jianguo Yin - Edison NJ, US
Xiaoyong Fu - Edison NJ, US
Shuyi Zhang - Parsipanny NJ, US
Timothy L. McAllister - Westfield NJ, US
Jason L. Winters - East Windsor NJ, US
Anantha Sudhakar - East Brunswick NJ, US
Doris P. Schumacher - Bedminster NJ, US

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

C07C 231/02
C07C 233/05

US Classification:

564167, 564142, 564166

Abstract:

Disclosed is a process for making the compound of formula I:.

US Patent:

47314478, Mar 15, 1988

Filed:

Mar 12, 1986

Appl. No.:

6/839016

Inventors:

Doris P. Schumacher - Florham Park NJ
Bruce L. Murphy - Elizabeth NJ
Jon E. Clark - Highland Park NJ

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

C07D22116

US Classification:

546 93

Abstract:

A process for the preparation of piperidylidene-dihydro-dibenzo[a,d]cycloheptene or aza-derivatives thereof and intermediates in such process are disclosed.

US Patent:

48639311, Sep 5, 1989

Filed:

Sep 15, 1988

Appl. No.:

7/244768

Inventors:

Doris P. Schumacher - Florham Park NJ
Bruce L. Murphy - Glen Ridge NJ
Jon E. Clark - Highland Park NJ

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

A61K 31445
C07D40104

US Classification:

514290

Abstract:

Certain benzocycloheptapyridine compounds with fluorine substitution across the exocyclic double bond are prepared and they are useful as antihistaminic agents.

US Patent:

58861718, Mar 23, 1999

Filed:

May 28, 1997

Appl. No.:

8/864529

Inventors:

Guang-Zhong Wu - Somerville NJ
Xing Chen - Plainsboro NJ
Doris P. Schumacher - Bedminster NJ
Martin Steinman - Livingston NJ

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

C07D20508

US Classification:

540200

Abstract:

The invention relates to a process for producing a compound of the formula ##STR1## wherein R. sub. 1, R. sub. 2 and R. sub. 3 are as defined in the specification, which comprises the steps of: (a) reacting a lactone with an imine to obtain a chiral diol of the formula IV; (b) oxidizing the diol to obtain an aldehyde of formula V; (c) condensing the aldehyde with an enolether followed by dehydration to obtain a compound of formula VI; (d) hydrogenating the compound of formula VI to obtain a ketone of formula VII; and (e) chirally catalytically reducing the ketone, wherein steps (b)-(d) are shown in the following reaction scheme: ##STR2##.