Dorothy J Margolskee

US Patent:

20060030535, Feb 9, 2006

Filed:

Mar 7, 2005

Appl. No.:

11/075648

Inventors:

Judith Healy - Lexington MA, US
Markus Kurz - Newton MA, US
Thomas McCauley - Cambridge MA, US
Kristin Thompson - Arlington MA, US
Charles Wilson - Concord MA, US
Dorothy Margolskee - Upper Montclair NJ, US

International Classification:

A61K 48/00
A61K 9/14

US Classification:

514044000, 424486000

Abstract:

Materials and methods are provided to modulate, in a controlled manner, the pharmacokinetic and biodistribution properties of nucleic acid aptamers, and to enhance their safety and efficacy properties as therapeutic agents.

US Patent:

20150087619, Mar 26, 2015

Filed:

Apr 26, 2013

Appl. No.:

14/397471

Inventors:

- Durham NC, US
Ernest Randall Lanier - Chapel Hill NC, US
Dorothy Margolskee - Voorhees NJ, US
Gwendolyn Powell Painter - Atlanta GA, US
Roy Ware - Raleigh NC, US

International Classification:

A61K 31/675

US Classification:

514 86

Abstract:

The present application provides methods and compositions for treatment or reducing risk of dsDNA virus infection in post-hematopoietic cell transplant (HCT or HSCT) patients. This application also provides methods and composition for reducing the incidence of BK virus associated hematuria and/or renal impairment. The invention also relates to a method of lowering BK viral load in post-hematopoietic cell transplant (HCT or HSCT) patients with HDP-CDV (HDP-CDV) or compound of Formula II, or a pharmaceutically acceptable salt thereof, thereby delaying onset of or reducing risk of end organ disease in these patients.