Douglas L Robinson

US Patent:

8187857, May 29, 2012

Filed:

Mar 17, 2005

Appl. No.:

10/593800

Inventors:

Douglas H. Robinson - Washington DC, US

Assignee:

Denovo Biologic LLC - Arlington VA

International Classification:

C12N 1/00
C12N 1/12
C12N 5/00

US Classification:

435243, 4352521, 435325

Abstract:

The present invention relates to pleomorphic cells (“morphotes”), which exhibit morphologic and genetic characteristics of both prokaryotic and eukaryotic cells, including resemblance to prokaryotic cells at the unicellular level, and resemblance to eukaryotic cells at the multicellular level due to their ability to self-organize in vitro into multicellular, mammalian tissue-like patterns consisting of tissue-like sheets, capillary-like networks, and trabecular (spongy) bone-like structures. Morphotes have a number of applications in the diagnostic medical, therapeutic medical, biological, biomaterials, bionanotechnological, and industrial fields.

US Patent:

20010018214, Aug 30, 2001

Filed:

Jan 16, 2001

Appl. No.:

09/759345

Inventors:

Douglas Robinson - Washington DC, US

International Classification:

C12N015/03
C12N015/02
C12N015/04
C12N015/08

US Classification:

435/454000

Abstract:

Bacteria containing eukaryotic and/or viral genes, and often having highly pleiomorphic morphology, are obtained by culturing virally-infected eukaryotic cells under aseptic, low oxygen conditions. The bacteria so produced express products encoded by the eukaryotic genes. Analyses indicate that several isolates obtained from culturing retrovirally-infected human brain capillary endothelial cells express human-specific genes previously mapped to widely separated human chromosomes.

US Patent:

51802228, Jan 19, 1993

Filed:

Nov 6, 1991

Appl. No.:

7/788370

Inventors:

Douglas J. Robinson - Washington DC

International Classification:

A47F 1110

US Classification:

362125

Abstract:

The present invention provides a display cabinet for displaying an object from a plurality of views, in which the observer's own image is not reflected. According to the present invention, at least one reflective surface such as mirrors are provided within a cabinet. The mirrors define an internal display chamber within the cabinet, with one of the faces of the display chamber constituting a viewing window having a special coating which allows some of the interior light to escape the display chamber. The lighting in the display chamber is controlled so as to ensure that more light exits the viewing window than enters from outside the display cabinet, thus ensuring that the observer's image is not reflected.

US Patent:

60227303, Feb 8, 2000

Filed:

Sep 25, 1996

Appl. No.:

8/719367

Inventors:

Douglas H. Robinson - Washington DC

International Classification:

C12Q 104
C12N 516
C12N 508

US Classification:

4352523

Abstract:

Bacteria containing eukaryotic and/or viral genes, and often having highly pleiomorphic morphology, are obtained by culturing virally-infected eukaryotic cells under aseptic, low oxygen conditions. The bacteria so produced express products encoded by the eukaryotic genes. Analyses indicate that several isolates obtained from culturing retrovirally-infected human brain capillary endothelial cells express human-specific genes previously mapped to widely separated human chromosomes.

US Patent:

55997031, Feb 4, 1997

Filed:

Oct 28, 1993

Appl. No.:

8/142569

Inventors:

Thomas A. Davis - Chantilly VA
Steven Kessler - Cupertino CA
Douglas H. Robinson - Washington DC

Assignee:

The United States of America as represented by the Secretary of the Navy - Washington DC

International Classification:

C12N 500
A01N 6300
A01N 6500

US Classification:

435373

Abstract:

The present invention relates to a method of amplifying in vitro stemcells. In this method hematopoietic CD34. sup. + stem and progenitor cells are isolated from human bone marrow and contacted with endothelial cells. The contacted stem cells and endothelial cells are cultured in the presence of at least one cytokine in an amount sufficient to support amplification/expansion of the hematopoietic CD34. sup. + stem and progenitor cells. This method produces increased yields of hematopoietic CD34. sup. + stem and progenitor cells which can be used in human therapeutics.