Douglas L Robinson

US Patent:

20210145746, May 20, 2021

Filed:

Dec 12, 2018

Appl. No.:

16/772518

Inventors:

- Baltimore MD, US
Takanari Inoue - Lutherville-Timonium MD, US
Tianzhi Luo - Hefei, Anhui, CN
Douglas Robinson - Lutherville-Timonium MD, US

International Classification:

A61K 9/127

Abstract:

This application is directed to methods which allow for encapsulation of an array of biological materials under physiological conditions that are relevant given a biological context and the compositions made using those methods. These reconstituted biological materials encompass: a) purified proteins that can bind to the lipid membranes inside and outside of vesicles based on the electrostatic charge; b) purified cytosolic proteins that position themselves in the lumen of the vesicles, c) mammalian cell extracts with an array of cytosolic protein content, among other contents and d) small biological molecules such as DNA and RNA as well as fluorescent dyes/probes. These vesicles can be used to simulate cells in drug discovery methods as well as useful in administering drugs and other compositions to cells in vitro and in vivo.

US Patent:

20200230213, Jul 23, 2020

Filed:

Oct 1, 2018

Appl. No.:

16/652501

Inventors:

- Baltimore MD, US
Douglas Robinson - Lutherville MD, US
Ramana Sidhaye - Clarksville MD, US
Jennifer Nguyen - Baltimore MD, US

International Classification:

A61K 38/45
G01N 33/50
C12N 15/86
C12N 9/12

Abstract:

Described are method of treating or preventing lung disease in a subject comprising the steps of: administering to a subject an agent that modulates the expression, the amount, or activity, of adenine nucleotide translocase (ANT) in the lungs of a subject. The treatment enhances airway surface (ASL) thickness in the lung of a subject compared to a lung of a reference subject that has not been given the agent.