Deoxyamino Acid Compounds, Pharmaceutical Compositions Comprising Same, And Methods For Inhibiting -Amyloid Peptide Release And/Or Its Synthesis By Use Of Such Compounds
James E. Audia - Indianapolis IN Warren J. Porter - Indianapolis IN Richard C. Thompson - Frankfort IN Stephen C. Wilkie - Indianapolis IN Douglas R. Stack - Fishers IN Qing Shi - Carmel IN
Assignee:
Elan Pharmaceuticals, Inc. - South San Francisco CA Eli Lilly and Company - Indianapolis IN
International Classification:
C07D24324
US Classification:
51421204, 51421207, 540522, 540523
Abstract:
Disclosed are compounds which inhibit -amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimers disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits -amyloid peptide release and/or its synthesis as well as methods for treating Alzheimers disease both prophylactically and therapeutically with such pharmaceutical compositions.
Cycloalkyl, Lactam, Lactone And Related Compounds, Pharmaceutical Compositions Comprising Same, And Methods For Inhibiting -Amyloid Peptide Release And/Or Its Synthesis By Use Of Such Compounds
Richard C. Thompson - Frankfort IN Stephen Wilkie - Indianapolis IN Douglas R. Stack - Fishers IN Eldon E. VanMeter - Greenwood IN Qing Shi - Carmel IN Thomas C. Britton - Carmel IN James E. Audia - Indianapolis IN Jon K. Reel - Carmel IN Thomas E. Mabry - Indianapolis IN Bruce A. Dressman - Indianapolis IN Cynthia L. Cwi - Indianapolis IN Steven S. Henry - New Palestine IN Stacey L. McDaniel - Martinsville IN Russell D. Stucky - Indianapolis IN Warren J. Porter - Indianapolis IN
Assignee:
Elan Pharmaceutials, Inc. - South San Francisco CA Eli Lilly Company - Indianapolis IN
Disclosed are compounds which inhibit -amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimers disease. Also disclosed are pharmaceutical compositions that include a compound which inhibits -amyloid peptide release and/or its synthesis as well as methods for treating Alzheimers disease both prophylactically and therapeutically with such pharmaceutical compositions.
Deoxyamino Acid Compounds, Pharmaceutical Compositions Comprising Same, And Methods For Inhibiting Beta-Amyloid Peptide Release And/Or Its Synthesis By Use Of Such Compounds
James E. Audia - Indianapolis IN, US Warren J. Porter - Indianapolis IN, US Richard C. Thompson - Frankfort IN, US Stephen C. Wilkie - Indianapolis IN, US Douglas R. Stack - Fishers IN, US Qing Shi - Carmel IN, US
Assignee:
Athena Neurosciences, Inc. - South San Francisco CA Eli Lilly & Company - Indianapolis IN
Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.
Cycloalkyl, Lactam, Lactone And Related Compounds, Pharmaceutical Compositions Comprising Same, And Methods For Inhibiting Β-Amyloid Peptide Release And/Or Its Synthesis By Use Of Such Compounds
Richard C. Thompson - Frankfort IN, US Stephen Wilkie - Indianapolis IN, US Douglas R. Stack - Fishers IN, US Eldon E. Vanmeter - Greenwood IN, US Qing Shi - Carmel IN, US Thomas C. Britton - Carmel IN, US James E. Audia - Indianapolis IN, US Jon K. Reel - Carmel IN, US Thomas E. Mabry - Indianapolis IN, US Bruce A. Dressman - Indianapolis IN, US Cynthia L. Cwi - Indianapolis IN, US Steven S. Henry - New Palestine IN, US Stacey L. McDaniel - Martinsville IN, US Russell D. Stucky - Indianapolis IN, US Warren J. Porter - Indianapolis IN, US
Assignee:
Elan Pharmaceuticals, Inc. - South San Francisco CA Eli Lilly & Company - Indianapolis IN
Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions that include a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.
Substituted N-Arylpyrrolidines As Selective Androgen Receptor Modulators
Konstantinos Gavardinas - Monrovia IN, US Prabhakar Kondaji Jadhav - Zionsville IN, US Douglas Richard Stack - Fishers IN, US
Assignee:
Eli Lilly and Company - Indianapolis IN
International Classification:
A61K 31/4025 C07D 207/06 C07D 207/08 C07D 207/10
US Classification:
514303, 548577
Abstract:
The present invention provides a compound of the Formula (I) or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising an effective amount of a compound of Formula (I) in combination with a suitable carrier, diluent, or excipient; and methods for treating physiological disorders, particularly frailty, osteoporosis, osteopenia, and male and female sexual dysfunction comprising administering to a patient in need thereof an effective amount of a compound of Formula (I).
Cycloalkyl, Lactam, Lactone And Related Compounds, Pharmaceutical Compositions Comprising Same, And Methods For Inhibiting Beta-Amyloid Peptide Release And/Or Its Synthesis By Use Of Such Compounds
Richard Thompson - Frankfort IN, US Stephen Wilkie - Indianapolis IN, US Douglas Stack - Fishers IN, US Eldon Vanmeter - Greenwood IN, US Qing Shi - Carmel IN, US Thomas Britton - Carmel IN, US James Audia - Indianapolis IN, US Jon Reel - Carmel IN, US Thomas Mabry - Indianapolis IN, US Bruce Dressman - Indianapolis IN, US Cynthia Cwi - Indianapoilis IN, US Steven Henry - New Palestine IN, US Stacey McDaniel - Martinsville IN, US Russell Stucky - Indianapolis IN, US Warren Porter - Indianapolis IN, US
Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions that include a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.
Cycloalkyl, Lactam, Lactone And Related Compounds, Pharmaceutical Compositions Comprising Same, And Methods For Inhibiting Beta-Amyloid Peptide Release And/Or Its Synthesis By Use Of Such Compounds
Richard Thompson - Frankfort IN, US Stephen Wilkie - Indianapolis IN, US Douglas Stack - Fishers IN, US Eldon Vanmeter - Greenwood IN, US Qing Shi - Carmel IN, US Thomas Britton - Carmel IN, US James Audia - Indianapolis IN, US Jon Reel - Carmel IN, US Thomas Mabry - Indianapolis IN, US Bruce Dressman - Indianapolis IN, US Cynthia Cwi - Indianapolis IN, US Steven Henry - New Palestine IN, US Stacey McDaniel - Martinsville IN, US Russell Stucky - Indianapolis IN, US Warren Porter - Indianapolis IN, US
International Classification:
A61K031/55 A61K031/501 A61K031/445
US Classification:
514212010, 514317000, 514424000
Abstract:
Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions that include a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.
Cycloalkyl, Lactam, Lactone And Related Compounds, Pharmaceutical Compositions Comprising Same, And Methods For Inhibiting Beta-Amyloid Peptide Release And/Or Its Synthesis By Use Of Such Compounds
Richard Thompson - Frankfort IN, US Stephen Wilkie - Indianapolis IN, US Douglas Stack - Fishers IN, US Eldon Vanmeter - Greenwood IN, US Qing Shi - Carmel IN, US Thomas Britton - Carmel IN, US James Audia - Indianapolis IN, US Jon Reel - Carmel IN, US Thomas Mabry - Indianapolis IN, US Bruce Dressman - Indianapolis IN, US Cynthia Cwi - Indianapolis IN, US Steven Henry - New Palestine IN, US Stacey McDaniel - Martinsville IN, US Russell Stucky - Indianapolis IN, US Warren Porter - Indianapolis IN, US
International Classification:
A61K031/4706 A61K031/445
US Classification:
514309000, 514317000, 514312000
Abstract:
Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions that include a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.
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