Douglas Barry Starr

US Patent:

7189506, Mar 13, 2007

Filed:

Mar 3, 2000

Appl. No.:

09/518297

Inventors:

Moon Young Lim - Redwood City CA, US
Cynthia A. Edwards - Morgan Hill CA, US
Kirk E. Fry - Palo Alto CA, US
Thomas W. Bruice - Carlsbad CA, US
Douglas B. Starr - Mountain View CA, US
Megan E. Laurance - San Francisco CA, US
Yan Kwok - Sunnyvale CA, US
Albert W. Tam - San Francisco CA, US

Assignee:

Genelabs Technologies, Inc. - Redwood City CA

International Classification:

C12Q 1/68
C07H 21/04

US Classification:

435 6, 435 721, 435 723, 435 691, 4352351, 436501, 536 231, 536 234, 536 235, 536 236, 536 237

Abstract:

The present invention provides molecular switch system methods and compositions for use in regulatable gene expression. The system includes a nucleic acid construct which has a DNA response sequence for a transcriptional regulatory protein operably linked to a promoter, a compound binding sequence in the vicinity of the DNA response sequence, a transgene under the control of the promoter; and a DNA binding compound. In some cases, the molecular switch system further includes a nucleic acid sequence encoding a transcriptional regulatory protein operably linked to a second promoter. The invention further provides a method for screening compounds for the ability to function in the molecular switch system and thereby regulate gene expression.

US Patent:

20030027320, Feb 6, 2003

Filed:

Jun 6, 2001

Appl. No.:

09/875453

Inventors:

Jungsuh Kim - Palo Alto CA, US
Douglas Starr - Mountain View CA, US
Albert Tam - San Francisco CA, US
Megan Laurance - San Francisco CA, US
Emil Michelotti - Foster City CA, US
Mark Velligan - Montara CA, US
Derek Latour - Hayward CA, US
Rita Thomas - San Jose CA, US
Ana Kongpachith - Union City CA, US
Liana Sheppard - Redwood City CA, US
Moon Kim - Redwood City CA, US
Thomas Bruice - Carlsbad CA, US

International Classification:

C12Q001/70
C07H021/04
C12N009/00
C12N007/00

US Classification:

435/235100, 435/183000, 536/023720, 435/005000

Abstract:

This invention provides nucleic acid sequences, vectors and host cells comprising regulatory regions associated with various promoters including a cyclin D1 promoter, a CD40L promoter, three HBV promoters (core, pre-S1 and HBV-X), a vancomycin-resistant enterococci (VRE) promoter, an androgen receptor promoter, a Her2 promoter, and -lactamase promoter. The invention further provides methods of regulating gene expression comprising the regulatory regions of such promoters.