Douglas W Swanson

US Patent:

57392188, Apr 14, 1998

Filed:

Jun 2, 1997

Appl. No.:

8/867143

Inventors:

Petar R. Dvornic - Midland MI
Douglas Swanson - Midland MI
Michael James Owen - Midland MI
Susan Victoria Perz - Essexville MI

Assignee:

Dow Corning Corporation - Midland MI
Michigan Molecular Institute - Midland MI

International Classification:

C07F28300

US Classification:

525487

Abstract:

Radially layered copoly-dendrimers having unusual surface properties and novel applications have been synthesized and characterized. These are the first copolymeric dendrimers composed of a hydrophilic poly(amidoamine) (PAMAM) interior with hydrophobic organosilicon surfaces. These dendrimers have been prepared by surface modifications of an ethylene diamine core PAMAM dendrimer with (3-acryloxypropyl)methyldimethoxysilane, (3-acryloxypropyl)bis(vinyldimethylsiloxy)methylsilane, (3-acryloxypropyl)tris(trimethylsiloxy)silane, chloromethyltrimethylsilane, and chloromethyldimethylvinylsilane, to varying degrees of surface coverage. The obtained products were characterized by. sup. 1 H,. sup. 13 C, and. sup. 29 Si NMR, and by DSC and TGA.

US Patent:

59194421, Jul 6, 1999

Filed:

Aug 9, 1996

Appl. No.:

8/694787

Inventors:

Rui Yin - Midland MI
Donald A. Tomalia - Midland MI
David M. Hedstrand - Midland MI
Douglas R. Swanson - Midland MI
James R. Baker - Ann Arbor MI
Jolanta F. Kukowska-Latallo - Ann Arbor MI

Assignee:

Dendritech, Inc. - Midland MI
University of Michigan - Ann Arbor MI

International Classification:

A61K 3174
A01N 2510

US Classification:

424 7818

Abstract:

A novel class of hyper comb-branched polymers conjugated with carried materials are disclosed.

US Patent:

57055734, Jan 6, 1998

Filed:

Sep 5, 1996

Appl. No.:

8/708677

Inventors:

Douglas R. Swanson - Midland MI
Donald A. Tomalia - Midland MI

Assignee:

Michigan Molecular Institute - Midland MI

International Classification:

C08F 800

US Classification:

525343

Abstract:

A novel process for preparing poly(2-isopropenyl-2-oxazoline or oxazine) and its methyl methacrylate copolymer, which are useful as water borne curing agents, particularly in the non-stick coating industry. The process converts commercially available poly(methyl methacrylate) into poly(2-isopropenyl-2-oxazoline or oxazine) polymers or copolymers with methyl methacrylate, while circumventing the use of the highly toxic monomer, 2-isopropenyl-2-oxazoline or oxazine. The process involves converting a poly(methacrylic ester) to the corresponding poly(. beta. -hydroxy-N-ethyl or propyl methacrylamide) and activating the ring-forming. beta. -hydroxy-N-ethyl or propyl methacrylamide moiety to form an oxazoline or oxazine ring.

US Patent:

60204575, Feb 1, 2000

Filed:

Sep 30, 1997

Appl. No.:

8/941527

Inventors:

June W. Klimash - Midland MI
Herbert M. Brothers - Midland MI
Douglas R. Swanson - Midland MI
Rui Yin - Bel Air MD
Ralph Spindler - Midland MI
Donald A. Tomalia - Midland MI
Yong Hsu - Woodbury MN
Roberta C. Cheng - Midland MI

Assignee:

Dendritech Inc. - Midland MI

International Classification:

C08G 6900
C08G 7300

US Classification:

528373

Abstract:

Dendritic polymers containing disulfide functional groups which are essentially inert under non-reducing conditions, but which form sulfhydryl groups upon being subjected to a reducing agent are prepared by synthesizing dendritic polymers having a core with a disulfide linkage or by reacting a dendritic polymer with a molecule containing a disulfide linkage and reactive terminal groups. In one aspect of the invention, dendritic polymers having a single disulfide functional group at the core are provided. The single disulfide group at the core can be reduced to form two sulfhydryl groups to which other molecules, such as proteins, oligonucleotides, peptides, hormones, other dendritic polymers, non-dendritic polymers, etc. , can be bound. Applications for the disulfide functionalized dendritic polymers include formation of differentiated dendrimers, formation of binding reagents for diagnostics, drug delivery, gene therapy and magnetic resins imaging, and in the preparation of self-assembled dendrimer monolayers on a quartz crystal resonators to provide dendrimer-modified electrodes which are useful for detecting various ions or molecules.

US Patent:

20100086482, Apr 8, 2010

Filed:

Dec 28, 2007

Appl. No.:

12/448513

Inventors:

Donald A. Tomalia - Midland MI, US
Douglas R. Swanson - Mt. Pleasant MI, US
Baohua Huang - Ann Arbor MI, US
Veera Reddy Pulgam - Mt. Pleasant MI, US

Assignee:

Dendritic Nanotechnologies, Inc. - Mt. Pleasant MI

International Classification:

A61K 49/00
C07D 487/00
C07D 491/00
A61K 31/395
C07D 245/00
A61K 31/495
A61K 31/16
G01N 33/566

US Classification:

424 91, 540469, 514450, 540467, 540460, 564135, 514250, 514616, 436 94

Abstract:

The present invention describes a process for preparing new looped dendrimer and dendron compounds by controlling the molar amount of branch cell reagent monomer that is combined with various cores bearing core-XR functionalities (e.g., primary, or secondary amines, thiol, or epoxy functionalities). These looped, macrocyclic structures are more robust to various conditions, with greater resistance to acid/base hydrolysis. Alternatively, the looped, macrocyclic structure may offer new orientations that would qualify it as a better chelation ligand for metals, and other similar uses.

US Patent:

20070298006, Dec 27, 2007

Filed:

Dec 21, 2005

Appl. No.:

11/630044

Inventors:

Donald Tomalia - Midland MI, US
Douglas Swanson - Mt. Pleasant MI, US
Baohua Huang - Mt. Pleasant MI, US
Veera Pulgam - Mt. Pleasant MI, US
Sonke Svenson - Midland MI, US
Lori Reyna - Midland MI, US
Michael Zhuravel - Mt. Pleasant MI, US
Abhay Chauhan - Mt. Pleasant MI, US
Cordell DeMattei - Mt. Pleasant MI, US
Joseph Heinzelmann - Saginaw MI, US

Assignee:

Dendritic Nanotechnologies, Inc. - Mt. Pleasant MI

International Classification:

A61K 31/785
A61K 31/74
A61K 47/30
A61K 48/00
B05D 3/12
C08G 63/48
C08G 65/329
C08K 3/04
C08K 3/22
C12N 15/87

US Classification:

424078030, 424078080, 427240000, 427393500, 435440000, 435459000, 435470000, 514772300, 524430000, 524440000, 524496000, 525403000, 525419000, 525451000, 525452000, 525474000, 525509000, 525534000, 525535000, 525054100, 525540000, 525055000

Abstract:

Dendritic polymers with enhanced amplification and interior functionality are disclosed. These dendritic polymers are made by use of fast, reactive ring-opening chemistry (or other fast reactions) combined with the use of branch cell reagents in a controlled way to rapidly and precisely build dendritic structures, generation by generation, with cleaner chemistry, often single products, lower excesses of reagents, lower levels of dilution, higher capacity method, more easily scaled to commercial dimensions, new ranges of materials, and lower cost. The dendritic compositions prepared have novel internal functionality, greater stability (e.g., thermal stability and less or no reverse Michael's reaction), and reach encapsulation surface densities at lower generations. Unexpectedly, these reactions of polyfunctional branch cell reagents with polyfunctional cores do not create cross-linked materials. Such dendritic polymers are useful as demulsifiers for oil/water emulsions, wet strength agents in the manufacture of paper, proton scavengers, polymers, nanoscale monomers, calibration standards for electron microscopy, making size selective membranes, and agents for modifying viscosity in aqueous formulations such as paint. When these dendritic polymers have a carried material associated with their surface and/or interior, then these dendritic polymers have additional properties for carrying materials due to the unique characteristics of the dendritic polymer, such as for drug delivery, transfection, and diagnostics.

US Patent:

20070244296, Oct 18, 2007

Filed:

Apr 20, 2005

Appl. No.:

10/594776

Inventors:

Donald Tomalia - Midland MI, US
Douglas Swanson - Mt. Pleasant MI, US
Baohua Huang - Mt. Pleasant MI, US
Veera Pulgam - Mt. Pleasant MI, US

Assignee:

Dendritic Nanotechnologies, Inc. - Mt. Pleasant MI

International Classification:

C08J 3/00
C08J 9/32
C08J 9/40
C08K 9/00

US Classification:

528423000, 528425000

Abstract:

Poly(ester-acrylate) and poly(ester/epoxide) dendrimers. These materials can be synthesized by utilizing the so-called “sterically induced stoichiometric” principles. The preparation of the dendrimers is carried out by reacting precursor amino/polyamino-functional core materials with various branch cell reagents. The branch cell reagents are dimensionally large, relative to the amino/polyamino-initiator core and when reacted, produce generation=1 dendrimers directly in one step. There is also a method by which the dendrimers can be stabilized and that method is the reaction of the dendrimers with surface reactive molecules to pacify the reactive groups on the dendrimers.

US Patent:

20080221300, Sep 11, 2008

Filed:

Mar 27, 2006

Appl. No.:

11/885244

Inventors:

Donald A. Tomalia - Midland MI, US
Veera Reddy Pulgam - Mt. Pleasant MI, US
Douglas R. Swanson - Mt.Pleasant MI, US
Baohua Huang - Mt.Pleasant MI, US

International Classification:

C08G 75/00

US Classification:

528373

Abstract:

This invention provides a cost effective process and new Janus dendrimers where at least two dendrons are attached at the core (with or without a connector group) and where at least two of the dendrons have different functionality. Preferred are those Janus dendrimers where at least one dendron is a PEHAM dendron. Thus these Janus dendrimers are heterobifunctional in character and use unique ligation chemistry with single site functional dendrons, di-dendrons and multi-dendrons. Also included are Janus dendrons which maybe used as intermediates to make the Janus dendrimers or to further react with another reactive moiety. These Janus dendrimers can provide several new dendrimer moieties, namely: combinatorial libraries of bifunctional structures; combined target director and signaling dendrimers; specific targeting entities for diagnostic and therapeutic applications, such as for example targeted MRI agents, targeted radionuclide delivery for diseases such as cancer, and targeted photosensitive or radiowave sensitive agents.