Douglas F Whitman

US Patent:

7955802, Jun 7, 2011

Filed:

Dec 13, 2007

Appl. No.:

11/956257

Inventors:

Douglas F. Whitman - Round Rock TX, US
Charles J. Collins - Austin TX, US

Assignee:

Luminex Corporation - Austin TX

International Classification:

C12Q 1/68
C12P 19/34

US Classification:

435 6, 435 912

Abstract:

The present invention provides methods and systems for real-time measurements of PCR with multiplexing capability. Certain embodiments relate to methods and systems that use fluorescently encoded superparamagnetic microspheres for the immobilization of amplification products during the PCR process, and an imaging chamber of a measurement device that is also capable of controllable thermal cycling for assisting the PCR process.

US Patent:

8288105, Oct 16, 2012

Filed:

May 25, 2011

Appl. No.:

13/115293

Inventors:

Douglas F. Whitman - Round Rock TX, US
Charles J. Collins - Austin TX, US

Assignee:

Luminex Corporation - Austin TX

International Classification:

C12Q 1/68
C12P 19/34

US Classification:

435 612, 435 912

Abstract:

The present invention provides methods and systems for real-time measurements of PCR with multiplexing capability. Certain embodiments relate to methods and systems that use fluorescently encoded superparamagnetic microspheres for the immobilization of amplification products during the PCR process, and an imaging chamber of a measurement device that is also capable of controllable thermal cycling for assisting the PCR process.

US Patent:

20070020671, Jan 25, 2007

Filed:

Jul 12, 2006

Appl. No.:

11/485167

Inventors:

Ray Radtkey - San Diego CA, US
Douglas Whitman - Austin TX, US
Graham Lidgard - La Jolla CA, US

International Classification:

C12Q 1/68
C12P 19/34

US Classification:

435006000, 435091200

Abstract:

Methods for querying biological samples to detect genetic mutations, particularly insertions and deletions, by co-amplification of a gene of interest in conjunction with a paralogous gene. When the gene of interest and the corresponding paralogous gene are selected from the CYP450 family, the resulting ratios may predict how a particular patient metabolizes certain prescription drugs.

US Patent:

20090087846, Apr 2, 2009

Filed:

May 9, 2008

Appl. No.:

12/118312

Inventors:

Ray R. Radtkey - San Diego CA, US
Douglas Whitman - Austin TX, US
Graham Lidgard - La Jolla CA, US

International Classification:

C12Q 1/68

US Classification:

435 6

Abstract:

Methods for querying biological samples to detect genetic mutations, particularly insertions and deletions, by co-amplification of a gene of interest in conjunction with a paralogous gene. When the gene of interest and the corresponding paralogous gene are selected from the CYP450 family, the resulting ratios may predict how a particular patient metabolizes certain prescription drugs.

US Patent:

20100330574, Dec 30, 2010

Filed:

Jun 29, 2010

Appl. No.:

12/826189

Inventors:

Douglas F. Whitman - Round Rock TX, US
Hongwei Zhang - Toronto, CA

International Classification:

C12Q 1/68
C07H 21/00
C12P 19/34
G01N 33/566

US Classification:

435 6, 536 2433, 435 912, 436501

Abstract:

Methods and compositions for nucleic acid amplification, detection, and genotyping techniques are disclosed. In one embodiment, a nucleic acid molecule having a target-specific primer sequence; an anti-tag sequence 5′ of the target-specific primer sequence; a tag sequence 5′ of the anti-tag sequence; and a blocker between the anti-tag sequence and the tag sequence is disclosed. Compositions containing such a nucleic acid molecule and methods of using such a nucleic acid molecule are also disclosed.

US Patent:

20130085078, Apr 4, 2013

Filed:

Sep 28, 2012

Appl. No.:

13/631109

Inventors:

Brian Schrader - Austin TX, US
Douglas F. Whitman - Round Rock TX, US

International Classification:

C12Q 1/68
C40B 30/04
G01N 21/64

US Classification:

506 9, 435 611

Abstract:

Methods and compositions for the detection and quantification of nucleic acids are provided. In one embodiment, a sample is contacted with a primer complementary to a first region of a target nucleic acid and a probe complementary to a second region of the target nucleic acid downstream of the first region under conditions suitable for hybridization of the target nucleic acid with the primer and the probe. The probe in this embodiment comprises a fluorophore and is attached to a solid support. The hybridized probe is cleaved with a nucleic acid polymerase having exonuclease activity to release the reporter from the solid support. The presence of the target nucleic acid is then detected and optionally quantified by detecting a decrease in signal from the reporter on the solid support.

US Patent:

20130116141, May 9, 2013

Filed:

Sep 18, 2012

Appl. No.:

13/622277

Inventors:

Douglas F. Whitman - Round Rock TX, US
Charles J. Collins - Austin TX, US

Assignee:

Luminex Corporation - Austin TX

International Classification:

C12Q 1/68

US Classification:

506 9

Abstract:

The present invention provides methods and systems for real-time measurements of PCR with multiplexing capability. Certain embodiments relate to methods and systems that use fluorescently encoded superparamagnetic microspheres for the immobilization of amplification products during the PCR process, and an imaging chamber of a measurement device that is also capable of controllable thermal cycling for assisting the PCR process.

US Patent:

20230041131, Feb 9, 2023

Filed:

Sep 14, 2022

Appl. No.:

17/931973

Inventors:

- Austin TX, US
Steve KRUEGER - Austin TX, US
Douglas WHITMAN - Austin TX, US
Blaine OLDHAM - Austin TX, US
Tabitha VANDERSTOEP - Austin TX, US

Assignee:

LUMINEX CORPORATION - Austin TX

International Classification:

B01L 7/00

Abstract:

This disclosure relates to apparatus and methods for thermally cycling a sample. Particular embodiments comprise a first pivot arm configured to pivot around a first pivot axis; a second pivot arm configured to pivot around a second pivot axis; a first thermal mass and a second thermal mass coupled to the first pivot arm; and a third thermal mass and a fourth thermal mass coupled to the second pivot arm, wherein the first and third thermal masses are proximal to the sample when the first and second pivot arms are in a first position, and the second and fourth thermal masses are proximal to the sample when the first and second pivot arms are in a second position.