Dvir A Yelin

US Patent:

7447408, Nov 4, 2008

Filed:

Jul 1, 2005

Appl. No.:

11/174425

Inventors:

Brett E. Bouma - Quincy MA, US
Guillermo J. Tearney - Cambridge MA, US
Dvir Yelin - Brookline MA, US

Assignee:

The General Hospital Corproation - Boston MA

International Classification:

G02B 6/02
G01J 3/00
G01J 3/40
G01B 9/02

US Classification:

385123, 385126, 385127, 356300, 356302, 356450, 356477

Abstract:

A method and apparatus for imaging using a double-clad fiber is described.

US Patent:

7551293, Jun 23, 2009

Filed:

Nov 24, 2004

Appl. No.:

10/997789

Inventors:

Dvir Yelin - Brookline MA, US
Brett E. Bouma - Quincy MA, US
Nicusor Iftimia - Chelmsford MA, US
Guillermo J. Tearney - Cambridge MA, US

Assignee:

The General Hospital Corporation - Boston MA

International Classification:

G01J 3/45
G01B 9/02
G01B 11/02

US Classification:

356497, 356456, 356511

Abstract:

A method and apparatus for providing information associated with at least one portion of a sample can be provided. For example, at least one wavelength of electro-magnetic radiation provided on a sample can be encoded to determine at least one transverse location of the portion. A relative phase between at least one first electro-magnetic radiation electro-magnetic radiation being returned from a sample and at least one second electro-magnetic radiation returned from a reference can be obtained to determine at least one relative depth location of the portion. Further, the information of the portion can be provided based on the transverse location and the relative depth location. For example, the information can be depth information and/or three-dimensional information associated with the portion of the sample.

US Patent:

7796270, Sep 14, 2010

Filed:

Jan 10, 2007

Appl. No.:

11/621694

Inventors:

Dvir Yelin - Brookline MA, US
Seok-Hyun Yun - Cambridge MA, US
Brett Eugene Bouma - Quincy MA, US
Guillermo J Tearney - Cambridge MA, US

Assignee:

The General Hospital Corporation - Boston MA

International Classification:

G01B 9/02
G01J 3/45
G01N 21/00

US Classification:

356456

Abstract:

Exemplary systems and methods for generating data associated with at least one portion of a sample can be provided. For example, according to one exemplary embodiment of such systems and methods, it is possible to provide a particular radiation using at least one first arrangement. The particular radiation can include at least one first electro-magnetic radiation directed to at least one sample and at least one second electro-magnetic radiation directed to a reference arrangement. The first radiation and/or the second radiation can comprise a plurality of wavelengths. The first electro-magnetic radiation can be spectrally dispersed along at least one portion of the sample. The second electro-magnetic radiation measured at two or more different lengths of the reference arrangement with respect to the first arrangement. Data can be generated which is associated with the first and second electro-magnetic radiations obtained at the two different lengths using at least one second arrangement which comprises a spectrometer arrangement.

US Patent:

7809225, Oct 5, 2010

Filed:

Sep 5, 2008

Appl. No.:

12/205775

Inventors:

Brett E. Bouma - Quincy MA, US
Guillermo J. Tearney - Cambridge MA, US
Dvir Yelin - Brookline MA, US

Assignee:

The General Hospital Corporation - Boston MA

International Classification:

G02B 6/02
G02B 6/06

US Classification:

385123, 385116, 385126

Abstract:

A method and apparatus for imaging using a double-clad fiber is described.

US Patent:

7809226, Oct 5, 2010

Filed:

Sep 5, 2008

Appl. No.:

12/205787

Inventors:

Brett E. Bouma - Quincy MA, US
Guillermo J. Tearney - Cambridge MA, US
Dvir Yelin - Brookline MA, US

Assignee:

The General Hospital Corporation - Boston MA

International Classification:

G02B 6/02
G02B 6/06

US Classification:

385123, 385116, 385126

Abstract:

A method and apparatus for imaging using a double-clad fiber is described.

US Patent:

7843572, Nov 30, 2010

Filed:

Sep 29, 2006

Appl. No.:

11/537170

Inventors:

Guillermo J. Tearney - Cambridge MA, US
Dvir Yelin - Brookline MA, US
Brett Eugene Bourna - Quincy MA, US

Assignee:

The General Hospital Corporation - Boston MA

International Classification:

G01B 9/02

US Classification:

356479

Abstract:

Exemplary method, apparatus and arrangement can be provided for obtaining information associated with a sample such as a portion of an anatomical structure. The information can be generated using first data, which can be based on a signal obtained from a location on the sample, and second data, where the second data can be obtained by combining a second signal received from the sample with a third reference signal. An image of a portion of the sample can also be generated based on the information. For example, the first data can be associated with spectral encoding microscopy data, and the second data can be associated with optical coherence tomography data.

US Patent:

7847949, Dec 7, 2010

Filed:

Sep 29, 2006

Appl. No.:

11/537048

Inventors:

Guillermo J. Tearney - Cambridge MA, US
Dvir Yelin - Brookline MA, US
Brett Eugene Bouma - Quincy MA, US

Assignee:

The General Hospital Corporation - Boston MA

International Classification:

G01B 9/02

US Classification:

356477

Abstract:

Method, apparatus and arrangement according an exemplary embodiment of the present invention can be provided for generating an image of at least one portion of an anatomical structure. For example, the portion can have an area greater than about 1 mm2, and the image can have a resolution a transverse resolution that is below about 10 μm. For example, light can be scanned over such portion so as to generate first information which is related to the portion, where the light may be provided through a diffraction arrangement to generate a spectrally dispersed line. Method, apparatus and arrangement according to a further exemplary embodiment of the present invention can be provided for positioning a radiation or optical beam within an anatomical structure based on signals generated by scanning a portion of the structure using the same or a different beam.

US Patent:

7859679, Dec 28, 2010

Filed:

May 31, 2006

Appl. No.:

11/445131

Inventors:

Brett Eugene Bouma - Quincy MA, US
Guillermo J. Tearney - Cambridge MA, US
Dvir Yelin - Brookline MA, US
Seok-Hyun Yun - Cambridge MA, US

Assignee:

The General Hospital Corporation - Boston MA

International Classification:

G01B 9/02
G01B 11/02

US Classification:

356479, 356497

Abstract:

Systems, arrangements and methods for obtaining three-dimensional imaging data are provided. For example, a broadband light source can provide a particular radiation. A first electro-magnetic radiation can be focused and diffracted, and then provided to at least one sample to generate a spectrally-encoded line. A second electro-magnetic radiation may be provided to a reference, which may include a double-pass rapidly-scanning optical delay, where the first and second electro-magnetic radiations can be based on the particular radiation. An interference between a third electro-magnetic radiation (associated with the first electro-magnetic radiation) and a fourth electro-magnetic radiation (associated with the second electro-magnetic radiation) can be detected. The spectrally-encoded line may be scanned over the sample in a direction approximately perpendicular to the line. Image data containing three-dimensional information can then be obtained based on the interference.