Dwight Arnold Towler

Address:

10618 Warlow Crk St, Orlando, FL 32832

VIN:

4T1BK36B47U239921

Make:

TOYOTA

Model:

AVALON

Year:

2007

US Patent:

6645974, Nov 11, 2003

Filed:

Jul 25, 2002

Appl. No.:

10/205634

Inventors:

John H. Hutchinson - La Jolla CA
Michael J. Breslin - Drexel Hill PA
Gideon A. Rodan - Bryn Mawr PA
Soumya P. Sahoo - Old Bridge NJ
Mark E. Duggan - Schwenksville PA
Azriel Schmidt - Bryn Mawr PA
Wasyl Halczenko - Lansdale PA
Dwight A. Towler - Brentwood MO

Assignee:

Merck Co., Inc. - Rahway NJ

International Classification:

A61K 3158

US Classification:

514284, 546 77

Abstract:

Compounds of structural formula (I) as herein defined are disclosed as useful in a method for modulating the androgen receptor in a tissue selective manner in a patient in need of such modulation, as well as in a method of agonizing the androgen receptor in a patient, and in particular the method wherein the androgen receptor is antagonized in the prostate of a male patient or in the uterus of a female patient and agonized in bone and/or muscle tissue. These compounds are useful in the treatment of conditions caused by androgen deficiency or which can be ameliorated by androgen administration, including: osteoporosis, periodontal disease, bone fracture, bone damage following bone reconstructive surgery, sarcopenia, frailty, aging skin, male hypogonadism, post-menopausal symptoms in women, atherosclerosis, hypercholesterolemia, hyperlipidemia, aplastic anemia and other hematopoietic disorders, pancreatic cancer, renal cancer, arthritis and joint repair, alone or in combination with other active agents. In addition, these compounds are useful as pharmaceutical composition ingredients alone and in combination with other active agents.

US Patent:

7060463, Jun 13, 2006

Filed:

May 3, 2002

Appl. No.:

10/476724

Inventors:

Dwight A. Towler - Brentwood MO, US
Fang Chen - North Wales PA, US

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

C12N 15/11
C12N 5/10
C12N 15/63

US Classification:

435 691, 4353201, 435325, 536 235

Abstract:

The present invention discloses the isolation and characterization of cDNA molecules encoding novel androgen receptor (AR) protein from. Also within the scope of the disclosure are recombinant vectors, recombinant host cells, methods of screening for modulators of AR (rhAR) activity, purified proteins and fusion proteins which comprise all or a portion of the rhAR protein, transgenic mice comprising a transgene encoding the rhAR protein, as well as production of antibodies against AR, or epitopes thereof.

US Patent:

20210290822, Sep 23, 2021

Filed:

Mar 16, 2021

Appl. No.:

17/202527

Inventors:

- Orlando FL, US
- La Jolla CA, US
William SELF - Oviedo FL, US
Dwight TOWLER - La Jolla CA, US

International Classification:

A61L 27/30
C25D 15/00
C25D 13/02
C25D 13/12
C25D 13/18
A61L 27/04
A61L 27/10
A61L 27/14
A61L 27/54

Abstract:

An implant is provided comprising a substrate having one or more nanoceria coatings coated at least partially thereon, wherein the one or more nanoceria coatings comprise surface cerium having a 3+/4+ oxidation state ratio such that the one or more nanoceria coatings exhibit catalase mimetic activity, superoxide dismutase mimetic activity, or both. Methods are provided for forming a nanoceria coating. The coating has nanoceria having a surface cerium 3+/4+ oxidation state ratio such that such that the coating exhibits catalase mimetic activity, superoxide dismutase mimetic activity, or both. Also disclosed is a method of reducing degradation of an implant by placing nanoceria in proximity to a bone-implant interface.

US Patent:

20190060519, Feb 28, 2019

Filed:

Oct 6, 2016

Appl. No.:

15/766582

Inventors:

- Orlando FL, US
- La Jolla CA, US
William SELF - Oviedo FL, US
Dwight TOWLER - La Jolla CA, US

International Classification:

A61L 27/30
A61L 27/54
A61L 27/14
A61L 27/04
A61L 27/10

Abstract:

An implant is provided comprising a substrate having one or more nanoceria coatings coated at least partially thereon, wherein the one or more nanoceria coatings comprise surface cerium having a 3+/4+ oxidation state ratio such that the one or more nanoceria coatings exhibit catalase mimetic activity, superoxide dismutase mimetic activity, or both. Methods are provided for forming a nanoceria coaling. The coating has nanoceria having a surface cerium 3+/4+ oxidation state ratio such that such that the coating exhibits catalase mimetic activity, superoxide dismutase mimetic activity, or both. Also disclosed is a method of reducing degradation of an implant by placing nanoceria in proximity to a bone-implant interface.