Edward L Adams

US Patent:

6649138, Nov 18, 2003

Filed:

Apr 23, 2001

Appl. No.:

09/841237

Inventors:

Edward William Adams - San Francisco CA

Assignee:

Quantum Dot Corporation - Hayward CA

International Classification:

B32B 516

US Classification:

423403, 428407

Abstract:

Water-dispersible nanoparticles are prepared by applying a coating of a multiply amphipathic dispersant to the surface of a hydrophobic nanoparticle comprised of a semiconductive or metallic material. The multiply amphipathic dispersant has two or more hydrophobic regions and two or more hydrophilic regions, and is typically polymeric. Preferred polymeric dispersants are comprised of (1) a hydrophobic backbone with hydrophilic branches, (2) a hydrophilic backbone with hydrophobic branches, or (3) a backbone that may be either hydrophobic or hydrophilic, and substituted with both hydrophilic and hydrophobic branches. Monodisperse populations of water-dispersible nanoparticles are also provided, as are conjugates of the water-dispersible nanoparticles with affinity molecules such as peptides, oligonucleotides, and the like.

US Patent:

7108915, Sep 19, 2006

Filed:

Nov 18, 2003

Appl. No.:

10/716971

Inventors:

Edward William Adams - San Francisco CA, US

Assignee:

Invitrogen Corp. - Carlsbad CA

International Classification:

B32B 5/16
A01N 25/26
A61K 31/04
A61J 33/24

US Classification:

428403, 428407, 4241791, 424490

Abstract:

Water-dispersible nanoparticles are prepared by applying a coating of a multiply amphipathic dispersant to the surface of a hydrophobic nanoparticle comprised of a semiconductive or metallic material. The multiply amphipathic dispersant has two or more hydrophobic regions and two or more hydrophilic regions, and is typically polymeric. Preferred polymeric dispersants are comprised of (1) a hydrophobic backbone with hydrophilic branches, (2) a hydrophilic backbone with hydrophobic branches, or (3) a backbone that may be either hydrophobic or hydrophilic, and substituted with both hydrophilic and hydrophobic branches. Monodisperse populations of water-dispersible nanoparticles are also provided, as are conjugates of the water-dispersible nanoparticles with affinity molecules such as peptides, oligonucleotides, and the like.

US Patent:

7147917, Dec 12, 2006

Filed:

Nov 18, 2003

Appl. No.:

10/717288

Inventors:

Edward William Adams - San Francisco CA, US

Assignee:

Invitrogen Corporation - Carlsbad CA

International Classification:

B32B 5/16
A61K 47/48

US Classification:

428403, 428407, 4241791, 4241941, 424490, 424497

Abstract:

Water-dispersible nanoparticles are prepared by applying a coating of a multiply amphipathic dispersant to the surface of a hydrophobic nanoparticle comprised of a semiconductive or metallic material. The multiply amphipathic dispersant has two or more hydrophobic regions and two or more hydrophilic regions, and is typically polymeric. Preferred polymeric dispersants are comprised of (1) a hydrophobic backbone with hydrophilic branches, (2) a hydrophilic backbone with hydrophobic branches, or (3) a backbone that may be either hydrophobic or hydrophilic, and substituted with both hydrophilic and hydrophobic branches. Monodisperse populations of water-dispersible nanoparticles are also provided, as are conjugates of the water-dispersible nanoparticles with affinity molecules such as peptides, oligonucleotides, and the like.

US Patent:

8158194, Apr 17, 2012

Filed:

Nov 23, 2009

Appl. No.:

12/624283

Inventors:

Edward Adams - San Francisco CA, US
Marcel Bruchez - Pittsburgh PA, US

Assignee:

Life Technologies Corporation - Carlsbad CA

International Classification:

B05D 7/00

US Classification:

427212, 427215, 427220

Abstract:

Water-dispersible nanoparticles are prepared by applying a coating of a amphipathic dispersant to the surface of a hydrophobic nanoparticle comprised of a semiconductive or metallic material. The amphipathic dispersant is typically polymeric. Preferred polymeric dispersants are comprised of (1) a hydrophobic backbone with hydrophilic branches, (2) a hydrophilic backbone with hydrophobic branches, or (3) a backbone that may be either hydrophobic or hydrophilic, and substituted with both hydrophilic and hydrophobic branches. Monodisperse populations of water-dispersible nanoparticles are also provided, as are conjugates of the water-dispersible nanoparticles with affinity molecules such as peptides, oligonucleotides, and the like.

US Patent:

20040101621, May 27, 2004

Filed:

Nov 18, 2003

Appl. No.:

10/717246

Inventors:

Edward Adams - San Francisco CA, US
Marcel Bruchez - Fremont CA, US

International Classification:

B05D007/00

US Classification:

427/222000

Abstract:

Water-dispersible nanoparticles are prepared by applying a coating of a multiply amphipathic dispersant to the surface of a hydrophobic nanoparticle comprised of a semiconductive or metallic material. The multiply amphipathic dispersant has two or more hydrophobic regions and two or more hydrophilic regions, and is typically polymeric. Preferred polymeric dispersants are comprised of (1) a hydrophobic backbone with hydrophilic branches, (2) a hydrophilic backbone with hydrophobic branches, or (3) a backbone that may be either hydrophobic or hydrophilic, and substituted with both hydrophilic and hydrophobic branches. Monodisperse populations of water-dispersible nanoparticles are also provided, as are conjugates of the water-dispersible nanoparticles with affinity molecules such as peptides, oligonucleotides, and the like.

US Patent:

20080241375, Oct 2, 2008

Filed:

Jan 11, 2008

Appl. No.:

12/013371

Inventors:

Edward William Adams - San Francisco CA, US
Marcel Bruchez Pierre - Fremont CA, US

Assignee:

INVITROGEN CORPORATION - Carlsbad CA

International Classification:

B05D 7/00

US Classification:

427221, 427212

Abstract:

Water-dispersible nanoparticles are prepared by applying a coating of a multiply amphipathic dispersant to the surface of a hydrophobic nanoparticle comprised of a semiconductive or metallic material. The multiply amphipathic dispersant has two or more hydrophobic regions and two or more hydrophilic regions, and is typically polymeric. Preferred polymeric dispersants are comprised of (1) a hydrophobic backbone with hydrophilic branches, (2) a hydrophilic backbone with hydrophobic branches, or (3) a backbone that may be either hydrophobic or hydrophilic, and substituted with both hydrophilic and hydrophobic branches. Monodisperse populations of water-dispersible nanoparticles are also provided, as are conjugates of the water-dispersible nanoparticles with affinity molecules such as peptides, oligonucleotides, and the like.

US Patent:

20120228565, Sep 13, 2012

Filed:

Mar 16, 2012

Appl. No.:

13/423055

Inventors:

Edward William Adams - San Francisco CA, US

Assignee:

LIFE TECHNOLOGIES CORPORATION - Carlsbad CA

International Classification:

G02F 1/35
B82Y 20/00

US Classification:

252582, 977773

Abstract:

Water-dispersible nanoparticles are prepared by applying a coating of a multiply amphipathic dispersant to the surface of a hydrophobic nanoparticle comprised of a semiconductive or metallic material. The multiply amphipathic dispersant has two or more hydrophobic regions and two or more hydrophilic regions, and is typically polymeric. Preferred polymeric dispersants are comprised of (1) a hydrophobic backbone with hydrophilic branches, (2) a hydrophilic backbone with hydrophobic branches, or (3) a backbone that may be either hydrophobic or hydrophilic, and substituted with both hydrophilic and hydrophobic branches. Monodisperse populations of water-dispersible nanoparticles are also provided, as are conjugates of the water-dispersible nanoparticles with affinity molecules such as peptides, oligonucleotides, and the like.

US Patent:

44655908, Aug 14, 1984

Filed:

Aug 17, 1983

Appl. No.:

6/524133

Inventors:

Edward C. Adams - Barto PA

Assignee:

American Mobile Oil Purification Co., Inc. - Lawrenceville NJ

International Classification:

C10G 1700

US Classification:

208262

Abstract:

A process for eliminating by destruction polychlorinated bi-phenyls from hydrocarbonaceous oil contaminated therewith is disclosed. The oil is admixed with liquid sodium in an atmosphere of argon gas and allowed by refluxing, mixing, agitation, and hydrogenation circulation to react therewith. The polychlorinated bi-phenyls are eliminated, the reaction products are filtered and the uncontaminated treated oil is rendered susceptible to re-use.