Edward Ganny Carroll

US Patent:

44359896, Mar 13, 1984

Filed:

Dec 4, 1981

Appl. No.:

6/327393

Inventors:

Richard C. Meyer - La Habra CA
Edward L. Carroll - Garden Grove CA

Assignee:

Beckman Instruments, Inc. - Fullerton CA

International Classification:

G01F 1300
B01L 302

US Classification:

7386414

Abstract:

Plunger operated pipet operable to execute different lengths of plunger movement during successive fluid pickup and fluid discharge operations or strokes. A stop member is movable between first and second locations in the pipet body to halt plunger movement at two different positions. A drive spring for driving the stop member from one location to the other is energized by a manually operable arming element and is retained in one location against action of the drive spring during a first plunger stroke. A release mechanism responsive to plunger movement during the first stroke disables the retaining means allowing the drive spring to move the stop member to the second location at which position the plunger is halted during the succeeding discharge stroke. The arming element is actuated by and in response to positioning of a replaceable tip on the pipet body. The arming element exerts a force on the tip sufficient to expel the tip from the body unless the tip is properly seated on the body thus ensuring that the pipet is armed if the tip is properly seated.

US Patent:

58635327, Jan 26, 1999

Filed:

Mar 14, 1996

Appl. No.:

8/615942

Inventors:

Jolinda A. Traugh - Riverside CA
Regina D. Rooney - Del Mar CA
Rolf Jakobi - Riverside CA
Polygena T. Tuazon - Riverside CA
William E. Meek - Colorado Springs CO
Edward J. Carroll - Riverside CA
Curtis A. Monnig - Riverside CA

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

A61K 3851
C12N 912
C12P 2106
C07H 2104

US Classification:

424 945

Abstract:

The present invention presents a unique class of physiological suppressors of cell division and cleavage. In particular, the present invention presents p21-activated protein kinase PAK I, also known as protease activated protein kinase I (with the same abbreviation "PAK I") which has been purified to apparent homogeneity. PAK I is inactive, e. g. as a protein of about 60 kDa (denoted "p60", as determined by polyacrylamide gel electrophoresis) and is active when autophosphorylated, for example, following limited proteolysis, or binding of Cdc42, e. g. , as a protein of about 58 kDa (denoted "p58" as determined by polyacrylamide gel electrophoresis). The present invention also presents a fragment of PAK I, a peptide denoted p37, which contains the catalytic domain of PAK I. The purification, characterization, nucleotide and amino acid sequences of PAK I and p37 are also disclosed. Another aspect of the invention discloses the cytostatic activity of PAK I and its fragments.