Edward Collin Murray

US Patent:

7786287, Aug 31, 2010

Filed:

Apr 11, 2003

Appl. No.:

10/510912

Inventors:

Osvaldo A. Flores - North Wales PA, US
Jay Grobler - Gwynedd PA, US
Edward M. Murray - Limerick PA, US
Paul D. Zuck - Trenton NJ, US

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

C07H 21/00
C12P 21/00
C12N 15/00
C12N 15/51
C12N 7/00

US Classification:

536 2372, 435 691, 4352351, 4353201

Abstract:

The present invention features assays employing a beta-lactamase reporter system, an HCV replicon enhanced cell, and/or a chimeric HCV replicon containing a 3′ UTR based on the HCV-1a 3′ UTR. These features can be employed alone or together, and are preferably combined together to measure HCV replicon activity and the affect of compounds on such activity.

US Patent:

61875481, Feb 13, 2001

Filed:

May 23, 1996

Appl. No.:

8/652877

Inventors:

Goran Akerstrom - Uppsala, SE
Claes Juhlin - Uppsala, SE
Lars Rask - Uppsala, SE
Goran Hjalm - Uppsala, SE
Clarence C. Morse - Royersford PA
Edward M. Murray - Drexel Hill PA
Gregg R. Crumley - Philadelphia PA

Assignee:

Rhone-Poulenc Rorer Pharmaceuticals Inc. - Collegeville PA

International Classification:

G01N 3353
G01N 33567

US Classification:

435 72

Abstract:

The present invention relates to the isolation of a cDNA clone encoding the calcium sensor in human placenta and subsequent Northern blots confirming the mRNA expression also in human parathyroid and kidney tubule cells. Close sequence similarity is demonstrated with the rat Heymann nephritis antigen, a glycoprotein of the kidney tubule brush border with calcium binding ability. Immunohistochemistry substantiates a tissue distribution of the calcium sensor protein similar to that previously described for the Heymann antigen. It is proposed that the identified calcium sensor protein constitutes a universal sensor for recognition of variation in extracellular calcium, and that it plays a key role for calcium regulation via different organ systems. The calcium sensor protein belongs to the LDL-superfamily of glycoproteins, claimed to function primarily as protein receptors, but with functionally important calcium binding capacity.

US Patent:

40226360, May 10, 1977

Filed:

Mar 29, 1976

Appl. No.:

5/671430

Inventors:

Edward Conley Murray - Oklahoma City OK

Assignee:

Kerr-McGee Chemical Corporation - Oklahoma City OK

International Classification:

C09C 136

US Classification:

106300

Abstract:

The present invention provides an improved process for coating titanium dioxide with precipitated alumina (aluminum oxide) for use as a pigment in plastics wherein a first coating of amorphous alumina is precipitated onto the titanium dioxide and then a second coating of crystalline alumina is precipitated over the first coating. In operation, the pH of an aqueous slurry of titanium dioxide pigment is adjusted to be within a first pH range as the first alumina coating is effected by adding an amount of sodium aluminate to the aqueous slurry and then the pH of the slurry is adjusted to be within a second pH range while a second amount of sodium aluminate is added to form the second coating over the first coating. The present invention also contemplates an improved titanium dioxide pigment having a first coating of amorphous alumina and a second coating of boehmite alumina.

US Patent:

62392700, May 29, 2001

Filed:

Jun 7, 1995

Appl. No.:

8/476515

Inventors:

Goran Akerstrom - Uppsala, SE
Claes Juhlin - Uppsala, SE
Lars Rask - Uppsala, SE
Goran Hjalm - Uppsala, SE
Clarence C. Morse - Royersford PA
Edward M. Murray - Drexel Hill PA
Gregg R. Crumley - Philadelphia PA

Assignee:

Rhone-Poulenc Rorer S.A. - Antony

International Classification:

A61K 317105
A61K 31711
C07H 2104

US Classification:

536 243

Abstract:

The present invention relates to the isolation of a cDNA clone encoding the calcium sensor in human placenta and subsequent Northern blots confirming the mRNA expression also in human parathyroid and kidney tubule cells. Close sequence similarity is demonstrated with the rat Heymann nephritis antigen, a glycoprotein of the kidney tubule brush border with calcium binding ability. Immunohistochemistry substantiates a tissue distribution of the calcium sensor protein similar to that previously described for the Heymann antigen. It is proposed that the identified calcium sensor protein constitutes a universal sensor for recognition of variation in extracellular calcium, and that it plays a key role for calcium regulation via different organ systems. The calcium sensor protein belongs to the LDL-superfamily of glycoproteins, claimed to function primarily as protein receptors, but with functionally important calcium binding capacity.

US Patent:

39819744, Sep 21, 1976

Filed:

May 20, 1974

Appl. No.:

5/471221

Inventors:

Peter Coad - Midwest City OK
Edward Conley Murray - Oklahoma City OK
Homer Charles Reed - Newport Beach CA

Assignee:

Kerr-McGee Chemical Corporation - Oklahoma City OK

International Classification:

C01B 1516
C01B 2526

US Classification:

423315

Abstract:

The present invention relates to a method for producing an alkali metal pyrophosphate useful, for example, as a plant food. Broadly, the method comprises reacting an alkali metal nitrate and aqueous phosphoric acid in the presence of catalytic amount of a metal oxide at a temperature of at least about 700. degree. C to produce a substantially pure alkali metal pyrophosphate and gaseous reaction products.