Edward Brian Newman

US Patent:

42230020, Sep 16, 1980

Filed:

Aug 28, 1978

Appl. No.:

5/937662

Inventors:

Edward S. Newman - Nutley NJ

Assignee:

Hoffmann-La Roche Inc. - Nutley NJ

International Classification:

G01N 3316
A61K 4300
C07G 700

US Classification:

424 1

Abstract:

A method of isolating alpha. sub. 1 -fetoprotein sufficiently pure to be useful in radioimmunoassay procedures is described. The method comprises the procedures and techniques of affinity chromatography, immobilized reactive dye adsorption chromatography and polyacrylamide gel electrophoresis. Wherein a certain degree of reduction in kind and/or quantity of contaminants is not achieved by the first two procedures, gel filtration and mixed ion exchange cellulose chromatography are carried out in preparation for polyacrylamide gel electrophoresis. Monkey alpha. sub. 1 -fetoprotein very similar to human cord blood alpha. sub. 1 -fetoprotein by amino acid composition and physical properties and of sufficient purity to be useful in human radioimmunoassay procedures is obtained by the disclosed method.

US Patent:

50654268, Nov 12, 1991

Filed:

Jul 18, 1989

Appl. No.:

7/382110

Inventors:

Harvey Greenstein - Iselin NJ
Charles B. Levinski - South River NJ
Edward Newman - Bricktown NJ
John M. Persel - Toms River NJ
David N. Widmann - Manasquan NJ

Assignee:

Hecon Corporation - Eatontown NJ

International Classification:

H04M 1100

US Classification:

379100

Abstract:

A microprocessor/based telephone/facsimile controller which automatically gives priority to incoming messages. The ring voltage of an incoming message causes the microprocessor to close and latch the line between the telephone and the facsimile. When transmission is completed, the line is dropped and this condition is sensed causing the latch relay to open to prevent the facsimile from transmitting, no data being logged for incoming facsimile transmissions. Only a valid input code permits the coupling of the facsimile to the telephone line also initiating a timer. A broadcast mode latches the telephone line to permit delayed calls and multiple facsimile transmissions, each allocated to the user code which established the broadcast mode. A default time is utilized to accommodate the redial and use of the line for non-facsimile telephone transmission.

US Patent:

41950739, Mar 25, 1980

Filed:

Jun 22, 1978

Appl. No.:

5/917814

Inventors:

Edward S. Newman - Nutley NJ

Assignee:

Hoffmann-La Roche Inc. - Nutley NJ

International Classification:

G01N 3316
A61K 4300
C07G 700

US Classification:

424 1

Abstract:

A method of isolating alpha. sub. 1 -fetoprotein sufficiently pure to be useful in radioimmunoassay procedures is described. The method comprises the procedures and techniques of affinity chromatography, blue dextran adsorption chromatography and polyacrylamide gel electrophoresis. Wherein a certain degree of reduction in kind and/or quantity of contaminants is not achieved by the first two procedures, gel filtration and mixed ion exchange cellulose chromatography are carried out in preparation for polyacrylamide gel electrophoresis. Monkey alpha. sub. 1 -fetoprotein very similar to human cord blood alpha. sub. 1 -fetoprotein by amino acid composition and physical properties and of sufficient purity to be useful in human radioimmunoassay procedures is obtained by the disclosed method.