Edward J Reich

US Patent:

44242018, Jan 3, 1984

Filed:

Nov 28, 1978

Appl. No.:

5/964359

Inventors:

Jay E. Valinsky - New York NY
Edward Reich - New York NY
Thomas G. Easton - New York NY

Assignee:

Rockefeller University - New York NY

International Classification:

G01N 130
G01N 2164
G01N 2300
C12Q 104
C12Q 116

US Classification:

424 3

Abstract:

A method for the detection of malignant leukocytic cells which comprises: contacting a fluid containing malignant leukocytic cells with a merocyanine dye of the formula: ##STR1## wherein n=1-5; X=0 or S; R. sub. 1 and R. sub. 2 are the same or different C. sub. 2 -C. sub. 5 alkyl groups: wherein said dye is incorporated into said cells; separating the cells from the incubation mixture; and detecting said dyed cells. Fluorescence or radioactivity detection methods are preferred detecting means.

US Patent:

42450519, Jan 13, 1981

Filed:

Mar 30, 1978

Appl. No.:

5/891808

Inventors:

Edward Reich - New York NY
Arabinda Guha - Pelham Manor NY
Wolf-Dieter Schleuning - New York NY

Assignee:

Rockefeller University - New York NY

International Classification:

C12N 948
A61K 3516

US Classification:

435212

Abstract:

A plasminogen proactivator and a corresponding activator has been isolated from mammalian and avian, especially human, plasma which is characterized within a given species as a single, electrophoretically and immunologically homogeneous protein. The activator acts as a catalyst to initiate fibrinolytic activity in plasma and is therefore useful in controlling clotting which occurs, e. g. in venous thrombosis or arterial occulsion, and in diagnosing conditions which predispose to thromboembolic phenomena. The proactivator has a long useful in vivo half life and can be used to provide a reservoir for maintaining the fibrolytic potential of blood.