- North Chicago IL, US Jieyi Wang - Belmont CA, US Archana Thakur - Pleasanton CA, US Debra Chao - Fremont CA, US Chung-Ming Hsieh - Newton MA, US Qian Zhang - Vernon Hills IL, US Edward B. Reilly - Libertyville IL, US Enrico L. Digiammarino - Lindenhurst IL, US Kenton L. Longenecker - Grayslake IL, US Russell A. Judge - Gurnee IL, US David A. Egan - Gurnee IL, US Charles W. Hutchins - Green Oaks IL, US
The present invention encompasses PRLR binding proteins. Specifically, the invention relates to antibodies that are chimeric, CDR grafted and humanized antibodies. Preferred antibodies have high affinity for hPRLR and neutralize hPRLR activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Methods of making and methods of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hPRLR and for inhibiting hPRLR activity, e.g., in a human subject suffering from a disorder in which hPRLR activity is detrimental. Also included in the invention are anti-PRLR antibody drug conjugates (ADCs).
Prolactin Receptor Binding Proteins And Uses Thereof
- North Chicago IL, US Jieyi Wang - Belmont CA, US Archana Thakur - Pleasanton CA, US Debra Chao - Fremont CA, US Chung-Ming Hsieh - Newton MA, US Qian Zhang - Vernon Hills IL, US Edward B. Reilly - Libertyville IL, US Enrico L. Digiammarino - Lindenhurst IL, US Kenton L. Longenecker - Grayslake IL, US Russell A. Judge - Gurnee IL, US David A. Egan - Gurnee IL, US Charles W. Hutchins - Green Oaks IL, US
International Classification:
C07K 16/28 A61K 39/395 A61K 45/06
Abstract:
The present invention encompasses PRLR binding proteins. Specifically, the invention relates to antibodies that are chimeric, CDR grafted and humanized antibodies. Preferred antibodies have high affinity for hPRLR and neutralize hPRLR activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Methods of making and methods of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hPRLR and for inhibiting hPRLR activity, e.g., in a human subject suffering from a disorder in which hPRLR activity is detrimental. Also included in the invention are anti-PRLR antibody drug conjugates (ADCs).
Prolactin Receptor Binding Proteins And Uses Thereof
- North Chicago IL, US Jieyi Wang - Belmont CA, US Archana Thakur - Pleasanton CA, US Debra Chao - Fremont CA, US Chung-Ming Hsieh - Newton MA, US Qian Zhang - Gurnee IL, US Edward B. Reilly - Libertyville IL, US Enrico L. Digiammarino - Lindenhurst IL, US Kenton L. Longenecker - Grayslake IL, US Russell A. Judge - Gurnee IL, US David A. Egan - Gurnee IL, US Charles W. Hutchins - Green Oaks IL, US
Assignee:
AbbVie Inc. - North Chicago IL
International Classification:
C07K 16/28 A61K 45/06 A61K 39/395
Abstract:
The present invention encompasses PRLR binding proteins. Specifically, the invention relates to antibodies that are chimeric, CDR grafted and humanized antibodies. Preferred antibodies have high affinity for hPRLR and neutralize hPRLR activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Methods of making and methods of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hPRLR and for inhibiting hPRLR activity, e.g., in a human subject suffering from a disorder in which hPRLR activity is detrimental. Also included in the invention are anti-PRLR antibody drug conjugates (ADCs).
Prolactin Receptor Binding Proteins And Uses Thereof
- North Chicago IL, US Jieyi Wang - Belmont CA, US Archana Thakur - Pleasanton CA, US Debra Chao - Fremont CA, US Chung-Ming Hsieh - Newton MA, US Qian Zhang - Gurnee IL, US Edward B. Reilly - Libertyville IL, US Enrico L. DiGiammarino - Lindenhurst IL, US Kenton L. Longenecker - Grayslake IL, US Russell A. Judge - Gurnee IL, US David A. Egan - Gurnee IL, US Charles W. Hutchins - Green Oaks IL, US
The present invention encompasses PRLR binding proteins. Specifically, the invention relates to antibodies that are chimeric, CDR grafted and humanized antibodies. Preferred antibodies have high affinity for hPRLR and neutralize hPRLR activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Methods of making and methods of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hPRLR and for inhibiting hPRLR activity, e.g., in a human subject suffering from a disorder in which hPRLR activity is detrimental. Also included in the invention are anti-PRLR antibody drug conjugates (ADCs).
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Geelonglecturer (sessional) at Victoria University Lecturer at Victoria University: MEd seminar (Approaches to learning) & BA (1st & 3rd year Literary Studies subjects)
Poetry & criticism published in Australia... Lecturer at Victoria University: MEd seminar (Approaches to learning) & BA (1st & 3rd year Literary Studies subjects)
Poetry & criticism published in Australia & USA, and also (in translation) in Lithuania.