- North Chicago IL, US Jieyi Wang - Belmont CA, US Archana Thakur - Pleasanton CA, US Debra Chao - Fremont CA, US Chung-Ming Hsieh - Newton MA, US Qian Zhang - Vernon Hills IL, US Edward B. Reilly - Libertyville IL, US Enrico L. Digiammarino - Lindenhurst IL, US Kenton L. Longenecker - Grayslake IL, US Russell A. Judge - Gurnee IL, US David A. Egan - Gurnee IL, US Charles W. Hutchins - Green Oaks IL, US
The present invention encompasses PRLR binding proteins. Specifically, the invention relates to antibodies that are chimeric, CDR grafted and humanized antibodies. Preferred antibodies have high affinity for hPRLR and neutralize hPRLR activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Methods of making and methods of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hPRLR and for inhibiting hPRLR activity, e.g., in a human subject suffering from a disorder in which hPRLR activity is detrimental. Also included in the invention are anti-PRLR antibody drug conjugates (ADCs).
Prolactin Receptor Binding Proteins And Uses Thereof
- North Chicago IL, US Jieyi Wang - Belmont CA, US Archana Thakur - Pleasanton CA, US Debra Chao - Fremont CA, US Chung-Ming Hsieh - Newton MA, US Qian Zhang - Vernon Hills IL, US Edward B. Reilly - Libertyville IL, US Enrico L. Digiammarino - Lindenhurst IL, US Kenton L. Longenecker - Grayslake IL, US Russell A. Judge - Gurnee IL, US David A. Egan - Gurnee IL, US Charles W. Hutchins - Green Oaks IL, US
International Classification:
C07K 16/28 A61K 39/395 A61K 45/06
Abstract:
The present invention encompasses PRLR binding proteins. Specifically, the invention relates to antibodies that are chimeric, CDR grafted and humanized antibodies. Preferred antibodies have high affinity for hPRLR and neutralize hPRLR activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Methods of making and methods of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hPRLR and for inhibiting hPRLR activity, e.g., in a human subject suffering from a disorder in which hPRLR activity is detrimental. Also included in the invention are anti-PRLR antibody drug conjugates (ADCs).
Prolactin Receptor Binding Proteins And Uses Thereof
- North Chicago IL, US Jieyi Wang - Belmont CA, US Archana Thakur - Pleasanton CA, US Debra Chao - Fremont CA, US Chung-Ming Hsieh - Newton MA, US Qian Zhang - Gurnee IL, US Edward B. Reilly - Libertyville IL, US Enrico L. Digiammarino - Lindenhurst IL, US Kenton L. Longenecker - Grayslake IL, US Russell A. Judge - Gurnee IL, US David A. Egan - Gurnee IL, US Charles W. Hutchins - Green Oaks IL, US
Assignee:
AbbVie Inc. - North Chicago IL
International Classification:
C07K 16/28 A61K 45/06 A61K 39/395
Abstract:
The present invention encompasses PRLR binding proteins. Specifically, the invention relates to antibodies that are chimeric, CDR grafted and humanized antibodies. Preferred antibodies have high affinity for hPRLR and neutralize hPRLR activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Methods of making and methods of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hPRLR and for inhibiting hPRLR activity, e.g., in a human subject suffering from a disorder in which hPRLR activity is detrimental. Also included in the invention are anti-PRLR antibody drug conjugates (ADCs).
Prolactin Receptor Binding Proteins And Uses Thereof
- North Chicago IL, US Jieyi Wang - Belmont CA, US Archana Thakur - Pleasanton CA, US Debra Chao - Fremont CA, US Chung-Ming Hsieh - Newton MA, US Qian Zhang - Gurnee IL, US Edward B. Reilly - Libertyville IL, US Enrico L. DiGiammarino - Lindenhurst IL, US Kenton L. Longenecker - Grayslake IL, US Russell A. Judge - Gurnee IL, US David A. Egan - Gurnee IL, US Charles W. Hutchins - Green Oaks IL, US
The present invention encompasses PRLR binding proteins. Specifically, the invention relates to antibodies that are chimeric, CDR grafted and humanized antibodies. Preferred antibodies have high affinity for hPRLR and neutralize hPRLR activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Methods of making and methods of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hPRLR and for inhibiting hPRLR activity, e.g., in a human subject suffering from a disorder in which hPRLR activity is detrimental. Also included in the invention are anti-PRLR antibody drug conjugates (ADCs).
Name / Title
Company / Classification
Phones & Addresses
Edward Reilly Manager
San Fernando Swap Meet & Flea Used Merchandise Stores
585 Glenoaks Blvd, San Fernando, CA 91340 Website: sanfernandoswapmeet.com
Edward Reilly
Keller Williams - Los Feliz Real Estate Agents and Managers
1660 Hillhurst Ave, Los Angeles, CA 90020
Edward Reilly President
Fti Consulting (Sc) Inc
Edward Reilly President, Vice-President
The Chestnut Group Inc
Edward L. Reilly Director
Texas Foundation for Psychiatric Education and Research
Edward J. Reilly Principal
Reilly Medical Consulting LLC
Edward Reilly Principal
Edward Reilly Jr
Edward J. Reilly Principal
Rellly, LLC Business Services at Non-Commercial Site
Geelonglecturer (sessional) at Victoria University Lecturer at Victoria University: MEd seminar (Approaches to learning) & BA (1st & 3rd year Literary Studies subjects)
Poetry & criticism published in Australia... Lecturer at Victoria University: MEd seminar (Approaches to learning) & BA (1st & 3rd year Literary Studies subjects)
Poetry & criticism published in Australia & USA, and also (in translation) in Lithuania.
I want to commend you for that because they have not been providing the Anne Arundel County delegation that information, which weve requested for over 12 months, and its problematic for us, Sen. Edward Reilly, R-Anne Arundel, said to Sen. James Robey, D-Howard, who explained the budget amendment
Date: Mar 14, 2012
Category: U.S.
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The Edward F. Reilly Lecture - Jason Altmire
The Pew Research Center reported that the vast majority of Americans s...
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Matthew O'Reilly: "Am I dying?" The honest an...
Matthew O'Reilly is a veteran emergency medical technician on Long Isl...
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O'Reilly MySQL CE 2010: Edward Screven, "Sta...
Edward Screven (Oracle Corporation), "State of the Dolphin"
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Senator Edward Reilly
Maryland State House.
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2m 22s
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Edward Reilly
Lived:
Los Angeles, CA Abington, PA Palmyra, NJ Lansdale, PA Newark, DE