Edward L Smithwick

US Patent:

39324893, Jan 13, 1976

Filed:

Nov 16, 1973

Appl. No.:

5/416703

Inventors:

Edward L. Smithwick - Indianapolis IN

Assignee:

Eli Lilly and Company - Indianapolis IN

International Classification:

C07C12506

US Classification:

260482C

Abstract:

Hydroxy- or thiol-substituted amino acids are t-butylated by reacting them with isobutylene in the presence of a catalyst comprising boron trifluoride and anhydrous phosphoric acid.

US Patent:

43315933, May 25, 1982

Filed:

Oct 31, 1980

Appl. No.:

6/202514

Inventors:

Edward L. Smithwick - Indianapolis IN
Robert C. A. Frederickson - Indianapolis IN
Robert T. Shuman - Greenwood IN

International Classification:

C07C10352

US Classification:

2601125E

Abstract:

Compounds of the formula ##STR1## and pharmaceutically acceptable non-toxic acid addition salts thereof, in which L and D, when applicable, define the chirality; R. sub. 1 and R. sub. 2 independently are hydrogen or C. sub. 1 -C. sub. 3 primary alkyl; R. sub. 3 is C. sub. 1 -C. sub. 4 primary or secondary alkyl or --CH. sub. 2 CH. sub. 2 --S--CH. sub. 3 ; R. sub. 4 is hydrogen or C. sub. 1 -C. sub. 3 primary alkyl; R. sub. 5 is hydrogen or C. sub. 1 -C. sub. 3 primary alkyl; Y is hydrogen or acetyl; and Z is ##STR2## --CH. sub. 2 OH, or --CN; subject to the limitation that no more than one of R. sub. 4 and R. sub. 5 is C. sub. 1 -C. sub. 3 primary alkyl; are useful analgesic agents.

US Patent:

39562190, May 11, 1976

Filed:

Oct 11, 1974

Appl. No.:

5/514165

Inventors:

Edward L. Smithwick - Indianapolis IN

Assignee:

Eli Lilly and Company - Indianapolis IN

International Classification:

C08K 501
C08K 502
C08K 514
C08K 534

US Classification:

260 302

Abstract:

A composition which is either polystyrene or a substituted polystyrene crosslinked with divinylbenzene and swollen by N-methyl-2-pyrrolidone, which composition is useful in purifying blocked synthetic peptides by means of gel exclusion chromatography and in solid-phase peptide synthesis.

US Patent:

42592348, Mar 31, 1981

Filed:

Jun 20, 1977

Appl. No.:

5/807849

Inventors:

Edward L. Smithwick - Indianapolis IN
Robert C. A. Frederickson - Indianapolis IN
Robert T. Shuman - Greenwood IN

Assignee:

Eli Lilly and Company - Indianapolis IN

International Classification:

C07C10352

US Classification:

2601125R

Abstract:

Compounds of the formula ##STR1## and pharmaceutically acceptable non-toxic acid addition salts thereof, in which L and D, when applicable, define the chirality; R. sub. 1 is hydrogen, C. sub. 1 -C. sub. 3 primary alkyl, or allyl; R. sub. 2 is hydrogen or C. sub. 1 -C. sub. 3 primary alkyl, subject to the limitation that when R. sub. 1 is allyl, R. sub. 2 is hydrogen; R. sub. 3 is hydrogen or C. sub. 1 -C. sub. 3 primary alkyl; R. sub. 4 is C. sub. 1 -C. sub. 4 primary or secondary alkyl; R. sub. 5 is hydrogen or C. sub. 1 -C. sub. 4 primary or secondary alkyl; R. sub. 6 is hydrogen or C. sub. 1 -C. sub. 3 primary alkyl; R. sub. 7 is hydrogen or C. sub. 1 -C. sub. 3 primary alkyl; Y is hydrogen or acetyl; Z is hydrogen of ##STR2## in which R. sub. 8 is C. sub. 1 -C. sub. 3 alkyl or hydrogen; and W is isopropyl, --VR. sub.

US Patent:

43223427, Mar 30, 1982

Filed:

Oct 31, 1980

Appl. No.:

6/202513

Inventors:

Edward L. Smithwick - Indianapolis IN
Robert C. A. Frederickson - Indianapolis IN
Robert T. Shuman - Greenwood IN

Assignee:

Eli Lilly and Company - Indianapolis IN

International Classification:

C07C10352

US Classification:

2601125E

Abstract:

Compounds of the formula ##STR1## and pharmaceutically acceptable non-toxic acid addition salts thereof, in which: L and D, when applicable, define the chirality; R. sub. 1 is hydrogen, C. sub. 1 -C. sub. 3 primary alkyl, or allyl; R. sub. 2 is hydrogen or C. sub. 1 -C. sub. 3 primary alkyl, subject to the limitation that when R. sub. 1 is allyl, R. sub. 2 is hydrogen; R. sub. 3 is hydrogen or C. sub. 1 -C. sub. 3 primary alkyl; R. sub. 4 is C. sub. 1 -C. sub. 4 primary or secondary alkyl; R. sub. 5 is hydrogen or C. sub. 1 -C. sub. 4 primary or secondary alkyl; R. sub. 6 is hydrogen or C. sub. 1 -C. sub. 3 primary alkyl; R. sub. 7 is hydrogen or C. sub. 1 -C. sub. 3 primary alkyl; Y is hydrogen or acetyl; Z is hydrogen or ##STR2## in which R. sub. 8 is C. sub. 1 14 C. sub. 3 alkyl or hydrogen; and W is isopropyl, --VR. sub.

US Patent:

41994990, Apr 22, 1980

Filed:

Aug 24, 1978

Appl. No.:

5/936437

Inventors:

Edward L. Smithwick - Indianapolis IN
Robert C. A. Frederickson - Indianapolis IN
Robert T. Shuman - Greenwood IN

Assignee:

Eli Lilly and Company - Indianapolis IN

International Classification:

C07C10352
A61K 3700

US Classification:

2601125R

Abstract:

Compounds of the formula ##STR1## and pharmaceutically acceptable non-toxic acid addition salts thereof, in which L and D define the chirality; R. sub. 1 and R. sub. 2 independently are hydrogen or C. sub. 1 -C. sub. 3 primary alkyl; R. sub. 3 is C. sub. 1 -C. sub. 4 primary or secondary alkyl, C. sub. 1 -C. sub. 2 hydroxyalkyl, or --CH. sub. 2 CH. sub. 2 --U--CH. sub. 3, in which U is O or S; R. sub. 4 is C. sub. 1 -C. sub. 3 primary alkyl; Y is hydrogen or acetyl; Z is --CH. sub. 2 OH or ##STR2## in which R. sub. 5 is C. sub. 1 -C. sub. 3 alkyl or hydrogen; and W is isopropyl, --VR. sub. 6, or --CH. sub. 2 --X--CH. sub. 3, in which V is O or S, R. sub. 6 is C. sub. 1 -C. sub. 4 alkyl or aralkyl, and X is O, S, or CH. sub. 2 --; are useful analgesic agents.

US Patent:

40565190, Nov 1, 1977

Filed:

May 10, 1976

Appl. No.:

5/685193

Inventors:

Jesse L. Bobbitt - Indianapolis IN
Edward L. Smithwick - Indianapolis IN

Assignee:

Eli Lilly and Company - Indianapolis IN

International Classification:

C07C10352

US Classification:

2601125R

Abstract:

The proteinase plasmin is assayed either colorimetrically or fluorometrically with a tripeptidyl-4-methoxy-2-naphthylamide substrate having the following general formula: ##STR1## The substrate is useful for either routine clinical assays or kinetic studies.