Edward D Walsh

US Patent:

20100221755, Sep 2, 2010

Filed:

Jun 16, 2008

Appl. No.:

12/663343

Inventors:

Frances Eun-Hyung Lee - Pittsford NY, US
Ignacio Sanz - Pittsford NY, US
Jessica Halliley - Marion NY, US
Ann R. Falsey - Rochester NY, US
Edward Walsh - Pittsford NY, US

Assignee:

University of Rochester - Rochester NY

International Classification:

G01N 33/53

US Classification:

435 724

Abstract:

Disclosed are methods and kits for early detection of antigen exposure through the presence or absence of antigen-specific antibodies.

US Patent:

20100260792, Oct 14, 2010

Filed:

Oct 22, 2008

Appl. No.:

12/738991

Inventors:

Yoshihiko Murata - Pittsford NY, US
Robert C. Rose - Geneseo NY, US
Edward E. Walsh - Pittsford NY, US
Ann R. Falsey - Rochester NY, US

Assignee:

UNIVERSITY OF ROCHESTER - Rochester NY

International Classification:

A61K 39/155
C07K 14/025
C12N 15/63
C12N 1/00
C12P 21/02
A61K 39/12
C07K 1/00
C07K 14/135
A61P 37/04
A61P 31/20
A61P 31/14

US Classification:

4241921, 530350, 4353201, 435243, 435 697, 42419611, 530402

Abstract:

The present invention is directed to a chimeric papillomavirus virus-like particle (VLP) or capsomere including an L1 polypeptide and, optionally, an L2 polypeptide, and a respiratory syncytial virus (RSV) protein or polypeptide fragment thereof comprising a first epitope, where the RSV protein or polypeptide fragment thereof is attached to one or both of the L1 and L2 polypeptides. Chimeric proteins, genetic constructions, and recombinant vectors and host cells suitable for expression of the constructs and making of the chimeric VLPs or capsomeres are also disclosed. Use of the VLPs or capsomeres, or a pharmaceutical composition containing the same, is contemplated for inducing a protective immune response against RSV.

US Patent:

20110229914, Sep 22, 2011

Filed:

Oct 21, 2010

Appl. No.:

12/909385

Inventors:

Frances Eun-Hyung Lee - Pittsford NY, US
Ignacio Sanz - Pittsford NY, US
Edward E. Walsh - Pittsford NY, US
Ann R. Falsey - Rochester NY, US
Jessica L. Halliley - Rochester NY, US

International Classification:

G01N 33/53

US Classification:

435 792

Abstract:

Disclosed are methods and kits for early detection of antigen exposure through the presence or absence of antigen-specific antibodies.

US Patent:

20110318376, Dec 29, 2011

Filed:

Dec 23, 2009

Appl. No.:

13/142184

Inventors:

Yoshihiko Murata - Pittsford NY, US
Edward E. Walsh - Pittsford NY, US

Assignee:

UNIVERSITY OF ROCHESTER - Rochester NY

International Classification:

A61K 39/155
C12N 15/45
C12N 15/63
C12N 1/21
A61P 37/02
C12N 1/19
C12N 5/10
C12N 1/13
C07K 14/135
A61P 31/14
C12N 15/62
C12N 1/15

US Classification:

4241861, 536 234, 536 2372, 4353201, 4352523, 43525234, 43525233, 43525411, 4352542, 435325, 435348, 435419, 4352572, 435358, 435367, 435352, 435365, 530322, 530324, 530326

Abstract:

The present invention is directed to self-folding, soluble, stable RSV G and F polypeptides that contain a neutralizing epitope. Fusion proteins and immunogenic conjugates containing the RSV G and F polypeptides, along with recombinant transgenes and vectors, and host cells suitable for expression of such genetic constructs are also disclosed. Use of the RSV G and F polypeptides, fusion proteins, immunogenic conjugates, or a pharmaceutical composition containing the same, is contemplated for inducing a protective immune response against RSV.

US Patent:

56914490, Nov 25, 1997

Filed:

May 25, 1995

Appl. No.:

8/450070

Inventors:

Peter R. Paradiso - Pittsford NY
Stephen W. Hildreth - Rochester NY
Branda T. Hu - Pittsford NY
Rasappa Arumugham - West Henrietta NY
Edward E. Walsh - Pittsford NY

Assignee:

Praxis Biologics, Inc. - Rochester NY

International Classification:

C07K 100
C07K 1400
C07K 1700
A61K 39155

US Classification:

530350

Abstract:

Polypeptides, nucleotides, and compositions useful for preparing diagnostic reagents for and vaccines against human Respiratory Syncytial Virus are disclosed. The polypeptides include short polypeptides which are related to a neutralizing and fusion epitope of the Respiratory Syncytial Virus fusion protein or a neutralizing epitope of the G protein.

US Patent:

42333890, Nov 11, 1980

Filed:

Jul 23, 1979

Appl. No.:

6/059818

Inventors:

Jose M. Fernandez - Rochester NY
Robert G. Cameron - Spencerport NY
Edward J. Walsh - Pittsford NY

Assignee:

Eastman Kodak Company - Rochester NY

International Classification:

G03C 724
G03C 140

US Classification:

430140

Abstract:

Fluorinated 1-hydroxy-2-naphthamide couplers which are N-substituted with a lower alkylphenoxybutyl ballasting group are disclosed as well as compositions and photographic elements containing these couplers in coupler solvent particles. The coupler solvent particles are comprised of a combination of a coupler solvent and the coupler capable of permitting the formation of a microcrystalline dye. Surprisingly these microcrystalline dyes exhibit a broadened absorption characteristic in the 750 to 850 nm region of the spectrum. Dye images having such absorption characteristics are particularly suited to forming integral infrared absorbing sound tracks in photographic elements, such as motion picture projection films.

US Patent:

39594157, May 25, 1976

Filed:

May 28, 1974

Appl. No.:

5/473469

Inventors:

Kyung S. Shim - Irvington NY
Edward N. Walsh - New City NY

Assignee:

Stauffer Chemical Company - Westport CT

International Classification:

C07F 908

US Classification:

260928

Abstract:

Products which are phosphorus containing oligomers having ##EQU1## linkages between phosphorus atoms and which are obtained by the self-condensation of. beta. -haloalkyl esters of pentavalent phosphorus acids or by condensation of these esters with an alkyl ester of a pentavalent phosphorus acid are treated after residual acidity has been neutralized with an alkylene oxide for a period of time which is sufficient to enable the alkylene oxide to act upon labile groups contained in the condensed product, i. e. , cyclic, pyro and bridged groups, and to neutralize any further acidity generated by the opening of such groups. The stabilized products formed by this process when incorporated in a polyurethane foam formulation produce a foam having superior green strength to a foam containing such products which have not been treated in accordance with this invention.

US Patent:

56398530, Jun 17, 1997

Filed:

Sep 20, 1989

Appl. No.:

7/409915

Inventors:

Peter R. Paradiso - Pittsford NY
Stephen W. Hildreth - Rochester NY
Branda T. Hu - Pittsford NY
Rasappa Arumugham - West Henrietta NY
Edward E. Walsh - Pittsford NY

Assignee:

Praxis Biologics, Inc. - Rochester NY

International Classification:

C07K 100
C07K 500
A61K 3800
A61K 39155

US Classification:

530324

Abstract:

Polypeptides, nucleotides, and compositions useful for preparing diagnostic reagents for and vaccines against human Respiratory Syncytial Virus are disclosed. The polypeptides include short polypeptides which are related to a neutralizing and fusion epitope of the Respiratory Syncytial Virus fusion protein or a neutralizing epitope of the G protein.