Edwin W Rubel from 3010 Esplanade, Seattle, WA 98117, age 83, Phone: (206)7064000

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Author
Edwin W. Rubel

ISBN #
0387209867

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Author
Edwin W. Rubel

ISBN #
0387949844

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Author
Edwin W. Rubel

ISBN #
0444808442

Assay For Compounds That Protect Against Sensory Hair Cell Death And Compounds Identified By Same
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US Patent:

20060188445, Aug 24, 2006
Filed:

Feb 22, 2006
Appl. No.:

11/359161
Inventors:

Henry Ou - Seattle WA, US
Felipe Santos - Seattle WA, US
Edwin Rubel - Seattle WA, US
David Raible - Seattle WA, US
Julian Simon - Seattle WA, US
International Classification:

A61K 49/00
US Classification:

424009200, 424009600
Abstract:

The present invention provides methods of identifying compounds that protect against ototoxicity induced by one or more noxious stimuli, and methods of treating an individual with compounds identified using the present screening methods. Also provided are compounds demonstrated to have otoprotective effects.

Compounds That Protect Against Sensory Hair Cell Death
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US Patent:

20090023751, Jan 22, 2009
Filed:

Jan 15, 2008
Appl. No.:

12/014470
Inventors:

Henry C. Ou - Seattle WA, US
Felipe Santos - Seattle WA, US
Edwin W. Rubel - Seattle WA, US
David W. Raible - Seattle WA, US
Julian A. Simon - Seattle WA, US
Assignee:

University of Washington - Seattle WA
Fred Hutchinson Cancer Research Center - Seattle WA
International Classification:

A61K 31/381
A61K 31/473
A61K 31/138
A61K 31/4965
A61K 31/403
US Classification:

51425506, 514448, 514443, 514297, 514651, 514411
Abstract:

The present invention provides methods of identifying compounds that protect against ototoxicity induced by one or more noxious stimuli, and methods of treating an individual with compounds identified using the present screening methods. Also provided are compounds demonstrated to have otoprotective effects.

Compositions And Methods For Protecting Sensory Hair Cells
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US Patent:

20110135756, Jun 9, 2011
Filed:

Dec 8, 2010
Appl. No.:

12/963396
Inventors:

Kelly N. Owens - Seattle WA, US
Anna L. Corke - Seattle WA, US
Henry C. Ou - Seattle WA, US
Edwin W. Rubel - Seattle WA, US
David W. Raible - Seattle WA, US
Julian A. Simon - Seattle WA, US
Assignee:

University of Washington - Seattle WA
Fred Hutchinson Cancer Research Center - Seattle WA
International Classification:

A61K 33/24
A61K 31/522
A61K 31/122
A61K 31/4965
A61K 31/546
A61K 31/4706
A61K 31/138
A61K 31/438
A61K 31/7036
A61P 17/00
A61P 27/16
US Classification:

424649, 51426334, 514682, 51425506, 514202, 514313, 514651, 514278, 51425216, 514 39
Abstract:

The invention provides compounds, compositions and methods that can be used for the attenuation of damage to sensory hair cells and symptoms thereof. More particularly, the invention identifies drugs that can be used to protect sensory hair cells from ototoxic medications, noise-induced damage and age-related loss.

Compounds And Methods For Preventing, Treating And/Or Protecting Against Sensory Hair Cell Death
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US Patent:

20160326186, Nov 10, 2016
Filed:

Jul 19, 2016
Appl. No.:

15/214241
Inventors:

- Seattle WA, US
Edwin Rubel - Seattle WA, US
Sarwat Chowdhury - Seattle WA, US
R. Jason Herr - Voorheesville NY, US
Qin Jiang - Latham NY, US
Xinchao Chen - Schenectady NY, US
Kelly N. Owens - Lake Forest Park WA, US
David Raible - Seattle WA, US
International Classification:

C07D 495/04
A61K 31/4365
A61K 31/4545
A61K 31/496
A61K 31/439
A61K 31/444
A61K 31/4709
A61K 31/4725
C07D 495/18
A61K 45/06
A61K 31/5377
Abstract:

Disclosed herein are compounds, and pharmaceutical compositions that include such compounds, for preventing, treating, and/or protecting against sensory hair cell death. Methods of using the compounds, alone or in combination with other therapeutic agents, are also disclosed.

Compounds And Methods For Preventing, Treating And/Or Protecting Against Sensory Hair Cell Death
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US Patent:

20150232476, Aug 20, 2015
Filed:

Sep 27, 2013
Appl. No.:

14/431025
Inventors:

- Seattle WA, US
Edwin Rubel - Seattle WA, US
Sarwat Chowdhury - Seattle WA, US
R. Jason Herr - Voorheesville NY, US
Qin Jiang - Latham NY, US
Xinchao Chen - Schenectady NY, US
Kelly N Owens - Lake Forest Park WA, US
David Raible - Seattle WA, US
International Classification:

C07D 495/04
A61K 45/06
A61K 31/5377
C07D 495/08
A61K 31/4365
A61K 31/496
Abstract:

Disclosed herein are compounds, and pharmaceutical compositions that include such compounds, for preventing, treating, and/or protecting against sensory hair cell death. Methods of using the compounds, alone or in combination with other therapeutic agents, are also disclosed.