Elizabeth D Barker

US Patent:

20110165243, Jul 7, 2011

Filed:

Dec 7, 2010

Appl. No.:

12/928206

Inventors:

Elizabeth Barker - Southaven MS, US

International Classification:

A61K 9/00
A61K 35/12
A61K 35/30
A61P 35/00
A61P 25/28

US Classification:

424484, 424 937

Abstract:

A process for concurrent delivery of multiple therapeutic agents via hydrogels. The process includes polymerizing a hydrogel and combining said hydrogel with at least two biologically therapeutic agents. Encapsulation of whole viable cells into polymerized hydrogel for transplantation is also disclosed.

US Patent:

20120322718, Dec 20, 2012

Filed:

Jun 18, 2012

Appl. No.:

13/507264

Inventors:

Elizabeth Barker - Southaven MS, US

International Classification:

A61K 47/36
A61K 38/02
A61P 35/00
A61K 31/7088
A61K 31/194
A61K 47/48
A61K 31/715

US Classification:

514 11, 514778, 514 54, 514 44 R, 514574

Abstract:

A starch-based Amygel for the controlled delivery of a biologically active agent is described. The Amygel comprises a dispersed phase, and a dispersion medium consisting substantially of an organic solvent. The dispersed phase includes a polymeric network comprising a hydrolyzable polymeric substance derived from starch, and a cross-linker. In various embodiments, the polymeric starch-derived network includes amylose, amylopectin, soluble starch or a combination thereof. The cross-linker is a molecule having at least two carboxyl moieties. The hyrogel is biocompatible and biodegradable, and suitable for loading with biologically active agents including small molecule therapeutics, macromolecules such as proteins, polysaccharides and nucleic acids. Upon administration to a host animal, the Amygel biodegrades, releasing as degradation products only naturally-occurring sugar molecules that are non-toxic and non-immunogenic to the host.

US Patent:

20100331232, Dec 30, 2010

Filed:

Jun 25, 2009

Appl. No.:

12/459123

Inventors:

Elizabeth Diana Barker - Southaven MS, US

International Classification:

A61K 38/00
A61K 47/26
A61K 31/7088
A61K 31/70
A61K 31/715
A61P 3/10
A61P 35/00

US Classification:

514 11, 514778, 514 44 R, 514 22, 514 54, 514 60

Abstract:

A starch-based hydrogel for the controlled delivery of a biologically active agent is described. The hydrogel comprises a dispersed phase, and a dispersion medium consisting substantially of water. The dispersed phase includes a polymeric network comprising a hydrolyzable polymeric substance derived from starch, and a cross-linker. In various embodiments, the polymeric starch-derived network includes amylose, amylopectin, or a combination thereof, or soluble starch. The cross-linker is a molecule having at least two carboxyl moieties. The hyrogel is biocompatible and biodegradable, and suitable for loading with biologically active agents ranging from small molecule therapeutics to macromolecules such as proteins, polysaccharides and nucleic acids. Upon administration to a host animal, the hydrogel biodegrades, releasing as degradation products only naturally-occurring sugar molecules that are non-toxic and non-immunogenic to the host.