Elizabeth J Hauser

US Patent:

20090226420, Sep 10, 2009

Filed:

Nov 10, 2006

Appl. No.:

12/084759

Inventors:

Elizabeth Hauser - Durham NC, US
Pascal Goldschmidt - Miami FL, US
Simon Gregory - Durham NC, US
William Kraus - Hillsborough NC, US
Jeffery Vance - Coral Gables FL, US

International Classification:

C12Q 1/68
A61K 39/395
A61P 9/00

US Classification:

4241301, 435 6

Abstract:

The invention relates to predicting, or aiding in predicting, which individuals are at risk of developing coronary artery disease. The invention provides a method for identifying an individual who has an altered risk for developing CAD. The invention further relates to methods of reducing the likelihood that a subject will develop CAD. The invention further provides reagents, nucleic acids and kits comprising nucleic acids containing a polymorphism in a CAD-determinative gene.

US Patent:

20110318726, Dec 29, 2011

Filed:

Mar 10, 2010

Appl. No.:

13/255568

Inventors:

Svati H. Shah - Durham NC, US
Christopher B. Newgard - Durham NC, US
William E. Kraus - Durham NC, US
Elizabeth R. Hauser - Durham NC, US
Geoffrey S. Ginsburg - Durham NC, US
L. Kristin Newby - Durham NC, US

International Classification:

C12Q 1/00
H01J 49/26
G01N 33/64
G01N 33/92
G01N 33/68
G01N 33/50

US Classification:

435 4, 436 86, 436112, 436128, 436 71, 436129, 250282

Abstract:

Methods of assessing the risk of cardiovascular disease in a subject by detecting the level of at least one metabolite in a sample from the subject are disclosed herein. The level of the metabolite is indicative of the risk of cardiovascular disease in the subject. The metabolites may be acylcarnitines, amino acids, ketones, free fatty acids or hydroxybutyrate. The cardiovascular disease may be risk of a cardiovascular event, presence of coronary artery disease or risk of development of coronary artery disease.

US Patent:

20120065080, Mar 15, 2012

Filed:

May 3, 2010

Appl. No.:

13/318768

Inventors:

William E. Kraus - Durham NC, US
Lauren R. Simel - Durham NC, US
Mark P. Donahue - Durham NC, US
Elizabeth R. Hauser - Durham NC, US

Assignee:

DUKE UNIVERSITY - Durham NC

International Classification:

C12Q 1/68
C40B 20/00

US Classification:

506 2, 435 611

Abstract:

Provided are methods of predicting a trait in a subject including obtaining information about at least a portion of a polynucleotide sequence of the subject, the polynucleotide sequence encoding the acid ceramidase polypeptide, and using the information to predict the expression of the trait in the subject. Further provided are methods of developing a treatment plan for a subject with a disease or condition responsive to exercise. The methods may include obtaining information about at least a portion of a polynucleotide sequence of the subject, the polynucleotide sequence encoding the acid ceramidase polypeptide, using the information to predict a trait selected from maintaining an exercise program and physiological responsiveness to an exercise program, and developing a treatment plan for the subject to treat the disease or condition.

US Patent:

20160265049, Sep 15, 2016

Filed:

Mar 10, 2016

Appl. No.:

15/066185

Inventors:

- Durham NC, US
Lauren R. Simel - Durham NC, US
Mark P. Donahue - Durham NC, US
Elizabeth R. Hauser - Durham NC, US

International Classification:

C12Q 1/68

Abstract:

Provided are methods of predicting a trait in a subject including obtaining information about at least a portion of a polynucleotide sequence of the subject, the polynucleotide sequence encoding the acid ceramidase polypeptide, and using the information to predict the expression of the trait in the subject. Further provided are methods of developing a treatment plan for a subject with a disease or condition responsive to exercise. The methods may include obtaining information about at least a portion of a polynucleotide sequence of the subject, the polynucleotide sequence encoding the acid ceramidase polypeptide, using the information to predict a trait selected from maintaining an exercise program and physiological responsiveness to an exercise program, and developing a treatment plan for the subject to treat the disease or condition.

US Patent:

20160195543, Jul 7, 2016

Filed:

Mar 10, 2016

Appl. No.:

15/066837

Inventors:

- Durham NC, US
Christopher B. Newgard - Durham NC, US
William E. Kraus - Durham NC, US
Elizabeth R. Hauser - Durham NC, US
Geoffrey S. Ginsburg - Durham NC, US
L. Kristin Newby - Durham NC, US

International Classification:

G01N 33/68
H01J 49/00
G06F 19/00
G01N 21/78

Abstract:

Methods of assessing the risk of cardiovascular disease in a subject by detecting the level of at least one metabolite in a sample from the subject are disclosed herein. The level of the metabolite is indicative of the risk of cardiovascular disease in the subject. The metabolites may be acylcarnitines, amino acids, ketones, free fatty acids or hydroxybutyrate. The cardiovascular disease may be risk of a cardiovascular event, presence of coronary artery disease or risk of development of coronary artery disease.