Elizabeth Eller Hauser

US Patent:

7807465, Oct 5, 2010

Filed:

Oct 27, 2005

Appl. No.:

11/260842

Inventors:

Jeffery M. Vance - Chapel Hill NC, US
Pascal J. Goldschmidt - Chapel Hill NC, US
Simon S. Gregory - Durham NC, US
William E. Kraus - Hillsborough NC, US
Elizabeth R. Hauser - Durham NC, US

Assignee:

Duke University - Durham NC

International Classification:

C12Q 1/68
C07H 21/02
C07H 21/04

US Classification:

436 6, 536 231, 536 235, 536 2431

Abstract:

The present invention provides methods of identifying a subject having an increased or decreased risk of developing cardiovascular disease, comprising: a) correlating the presence of one or more genetic markers in chromosome 3q13. 31 with an increased or decreased risk of developing cardiovascular disease; and b) detecting the one or more genetic markers of step (a) in the subject, thereby identifying the subject as having an increased or decreased risk of developing cardiovascular disease. Also provided are methods of identifying subjects with cardiovascular disease as having a good or poor prognosis, as well as methods of identifying effective treatment regimens for cardiovascular disease, based on correlation with genetic markers in chromosome 3q13. 31.

US Patent:

20070148661, Jun 28, 2007

Filed:

Jul 18, 2006

Appl. No.:

11/458228

Inventors:

Jeffery Vance - Chapel Hill NC, US
Pascal Goldschmidt - Miami FL, US
Elizabeth Hauser - Durham NC, US
William Kraus - Hillsborough NC, US

Assignee:

Duke University - Durham NC

International Classification:

C12Q 1/68
G06F 19/00

US Classification:

435006000, 702020000

Abstract:

The LSAMP gene can be used for cardiovascular disease risk assessment, in particular Left Main Disease. The genetic risk attributable to LSAMP adds to known cardiovascular disease risk factors. Assessment of risk attributable to LSAMP permits early initiation of preventive and therapeutic strategies. Given the pronounced clinical risk associated with Left Main Disease, such risk assessment should significantly reduce morbidity and mortality.

US Patent:

20090226420, Sep 10, 2009

Filed:

Nov 10, 2006

Appl. No.:

12/084759

Inventors:

Elizabeth Hauser - Durham NC, US
Pascal Goldschmidt - Miami FL, US
Simon Gregory - Durham NC, US
William Kraus - Hillsborough NC, US
Jeffery Vance - Coral Gables FL, US

International Classification:

C12Q 1/68
A61K 39/395
A61P 9/00

US Classification:

4241301, 435 6

Abstract:

The invention relates to predicting, or aiding in predicting, which individuals are at risk of developing coronary artery disease. The invention provides a method for identifying an individual who has an altered risk for developing CAD. The invention further relates to methods of reducing the likelihood that a subject will develop CAD. The invention further provides reagents, nucleic acids and kits comprising nucleic acids containing a polymorphism in a CAD-determinative gene.

US Patent:

20110070583, Mar 24, 2011

Filed:

Aug 19, 2010

Appl. No.:

12/806690

Inventors:

Jeffery M. Vance - Chapel Hill NC, US
Pascal Goldschmidt - Miami FL, US
Elizabeth Hauser - Durham NC, US
William Kraus - Hillsborough NC, US

International Classification:

C12Q 1/68
C12Q 1/02
C12Q 1/60

US Classification:

435 6, 435 29, 435 11

Abstract:

The LSAMP gene can be used for cardiovascular disease risk assessment, in particular Left Main Disease. The genetic risk attributable to LSAMP adds to known cardiovascular disease risk factors. Assessment of risk attributable to LSAMP permits early initiation of preventive and therapeutic strategies. Given the pronounced clinical risk associated with Left Main Disease, such risk assessment should significantly reduce morbidity and mortality.

US Patent:

20110318726, Dec 29, 2011

Filed:

Mar 10, 2010

Appl. No.:

13/255568

Inventors:

Svati H. Shah - Durham NC, US
Christopher B. Newgard - Durham NC, US
William E. Kraus - Durham NC, US
Elizabeth R. Hauser - Durham NC, US
Geoffrey S. Ginsburg - Durham NC, US
L. Kristin Newby - Durham NC, US

International Classification:

C12Q 1/00
H01J 49/26
G01N 33/64
G01N 33/92
G01N 33/68
G01N 33/50

US Classification:

435 4, 436 86, 436112, 436128, 436 71, 436129, 250282

Abstract:

Methods of assessing the risk of cardiovascular disease in a subject by detecting the level of at least one metabolite in a sample from the subject are disclosed herein. The level of the metabolite is indicative of the risk of cardiovascular disease in the subject. The metabolites may be acylcarnitines, amino acids, ketones, free fatty acids or hydroxybutyrate. The cardiovascular disease may be risk of a cardiovascular event, presence of coronary artery disease or risk of development of coronary artery disease.

US Patent:

20120065080, Mar 15, 2012

Filed:

May 3, 2010

Appl. No.:

13/318768

Inventors:

William E. Kraus - Durham NC, US
Lauren R. Simel - Durham NC, US
Mark P. Donahue - Durham NC, US
Elizabeth R. Hauser - Durham NC, US

Assignee:

DUKE UNIVERSITY - Durham NC

International Classification:

C12Q 1/68
C40B 20/00

US Classification:

506 2, 435 611

Abstract:

Provided are methods of predicting a trait in a subject including obtaining information about at least a portion of a polynucleotide sequence of the subject, the polynucleotide sequence encoding the acid ceramidase polypeptide, and using the information to predict the expression of the trait in the subject. Further provided are methods of developing a treatment plan for a subject with a disease or condition responsive to exercise. The methods may include obtaining information about at least a portion of a polynucleotide sequence of the subject, the polynucleotide sequence encoding the acid ceramidase polypeptide, using the information to predict a trait selected from maintaining an exercise program and physiological responsiveness to an exercise program, and developing a treatment plan for the subject to treat the disease or condition.

US Patent:

20160265049, Sep 15, 2016

Filed:

Mar 10, 2016

Appl. No.:

15/066185

Inventors:

- Durham NC, US
Lauren R. Simel - Durham NC, US
Mark P. Donahue - Durham NC, US
Elizabeth R. Hauser - Durham NC, US

International Classification:

C12Q 1/68

Abstract:

Provided are methods of predicting a trait in a subject including obtaining information about at least a portion of a polynucleotide sequence of the subject, the polynucleotide sequence encoding the acid ceramidase polypeptide, and using the information to predict the expression of the trait in the subject. Further provided are methods of developing a treatment plan for a subject with a disease or condition responsive to exercise. The methods may include obtaining information about at least a portion of a polynucleotide sequence of the subject, the polynucleotide sequence encoding the acid ceramidase polypeptide, using the information to predict a trait selected from maintaining an exercise program and physiological responsiveness to an exercise program, and developing a treatment plan for the subject to treat the disease or condition.

US Patent:

20160195543, Jul 7, 2016

Filed:

Mar 10, 2016

Appl. No.:

15/066837

Inventors:

- Durham NC, US
Christopher B. Newgard - Durham NC, US
William E. Kraus - Durham NC, US
Elizabeth R. Hauser - Durham NC, US
Geoffrey S. Ginsburg - Durham NC, US
L. Kristin Newby - Durham NC, US

International Classification:

G01N 33/68
H01J 49/00
G06F 19/00
G01N 21/78

Abstract:

Methods of assessing the risk of cardiovascular disease in a subject by detecting the level of at least one metabolite in a sample from the subject are disclosed herein. The level of the metabolite is indicative of the risk of cardiovascular disease in the subject. The metabolites may be acylcarnitines, amino acids, ketones, free fatty acids or hydroxybutyrate. The cardiovascular disease may be risk of a cardiovascular event, presence of coronary artery disease or risk of development of coronary artery disease.