Elizabeth K Holmes

US Patent:

7291497, Nov 6, 2007

Filed:

Sep 10, 2004

Appl. No.:

10/937872

Inventors:

Elizabeth A. Holmes - Palo Alto CA, US
Shaunak Roy - San Mateo CA, US
John Howard - Saratoga CA, US
Chengwang Wang - Mountain View CA, US

Assignee:

Theranos, Inc. - Menlo Park CA

International Classification:

A61M 31/00
A61M 25/00
A61M 5/32
A61M 5/00
C12Q 1/00
G01N 33/53
G01N 15/06
C12M 1/34
A61F 13/00

US Classification:

4352872, 604 65, 604 66, 604 67, 604267, 604272, 604191, 435 6, 435 71, 4352871, 424422, 424449, 422 681

Abstract:

The invention relates to an ingestible, implantable or wearable medical device comprising a microarray which comprises a bioactive agent capable of interacting with a disease marker biological analyte; a reservoir which comprises at least one therapeutic agent and is capable of releasing the therapeutic agent(s) from the medical device; and a plurality of microchips comprising a microarray scanning device capable of obtaining physical parameter data of an interaction between the disease marker biological analyte with the bioactive agent; a biometric recognition device capable of comparing the physical parameter data with an analyte interaction profile; optionally a therapeutic agent releasing device capable of controlling release of the therapeutic agent from the reservoirs; an interface device capable of facilitating communications between the microarray scanning device, biometric recognition device and the therapeutic agent releasing device; and an energy source to power the medical device. Specifically, the invention relates to a medical device capable of detecting an analyte in a bodily fluid comprising at least one microneedle capable of obtaining a sample of a bodily fluid, a first microchannel through which the sample flows and is in fluid communication with the at least one microneedle, a second microchannel in fluid communication with the first microchannel, through which a buffer flows, wherein the second channel comprises a microarray with a bioactive agent, a microarray scanning device to detect an interaction between the bioactive agent and the analyte in the bodily fluid; and an interface device.

US Patent:

7635594, Dec 22, 2009

Filed:

Mar 24, 2006

Appl. No.:

11/389409

Inventors:

Elizabeth A. Holmes - Palo Alto CA, US
Shaunak Roy - San Mateo CA, US
John Howard - Saratoga CA, US
Chengwang Wang - Palo Alto CA, US
Ian Gibbons - Portola Valley CA, US
Timothy M. Kemp - San Jose CA, US
Shize Daniel Qi - Arcadia CA, US

Assignee:

Theranos, Inc. - Palo Alto CA

International Classification:

G01N 35/02
G01N 35/08
C12Q 3/00
A61B 5/00
C12M 1/36

US Classification:

436 50, 436 43, 436 55, 422 67, 600582, 600583, 435 3, 4352861

Abstract:

This invention is in the field of medical devices. Specifically, the present invention provides portable medical devices that allow real-time detection of analytes from a biological fluid. The methods and devices are particularly useful for providing point-of-care testing for a variety of medical applications.

US Patent:

7888125, Feb 15, 2011

Filed:

Mar 24, 2006

Appl. No.:

11/388824

Inventors:

Ian Gibbons - Portola Valley CA, US
Chengwang Wang - Palo Alto CA, US
Shaunak Roy - San Mateo CA, US
Elizabeth A. Holmes - Palo Alto CA, US

Assignee:

Theranos, Inc. - Palo Alto CA

International Classification:

G01N 31/00
A61B 5/00

US Classification:

436 8, 436 55, 436164

Abstract:

The present invention provides methods of calibrating a fluidic device useful for detecting an analyte of interest in a bodily fluid. The invention also provides methods for assessing the reliability of an assay for an analyte in a bodily fluid with the use of a fluidic device. Another aspect of the invention is a method for performing a trend analysis on the concentration of an analyte in a subject using a fluidic device.

US Patent:

8007999, Aug 30, 2011

Filed:

May 9, 2007

Appl. No.:

11/746535

Inventors:

Elizabeth A. Holmes - Palo Alto CA, US
Ian Gibbons - Portola Valley CA, US

Assignee:

Theranos, Inc. - Palo Alto CA

International Classification:

C12Q 1/70
A61K 39/42
A61K 39/145

US Classification:

435 5, 4241591, 4242061

Abstract:

The present invention provides system and methods for detecting an analyte indicative of an influenza viral infection in a sample of bodily fluid. The present invention also provides for systems and method for detection a plurality of analytes, at least two of which are indicative of an influenza viral infection in a sample of bodily fluid.

US Patent:

8101402, Jan 24, 2012

Filed:

Aug 12, 2005

Appl. No.:

11/202206

Inventors:

Elizabeth A. Holmes - Burlingame CA, US

Assignee:

Theranos, Inc. - Palo Alto CA

International Classification:

C12M 3/00

US Classification:

4352872

Abstract:

The invention relates to an ingestible, implantable or wearable medical device comprising a microarray which comprises a bioactive agent capable of interacting with a disease marker biological analyte; a reservoir which comprises at least one therapeutic agent and is capable of releasing the therapeutic agent(s) from the medical device; and a plurality of microchips comprising a microarray scanning device capable of obtaining physical parameter data of an interaction between the disease marker biological analyte with the bioactive agent; a biometric recognition device capable of comparing the physical parameter data with an analyte interaction profile; optionally a therapeutic agent releasing device capable of controlling release of the therapeutic agent from the reservoirs; an interface device capable of facilitating communications between the microarray scanning device, biometric recognition device and the therapeutic agent releasing device; and an energy source to power the medical device. Specifically, the invention relates to a medical device capable of detecting an analyte in a bodily fluid comprising at least one microneedle capable of obtaining a sample of a bodily fluid, a first microchannel through which the sample flows and is in fluid communication with the at least one microneedle, a second microchannel in fluid communication with the first microchannel, through which a buffer flows, wherein the second channel comprises a microarray with a bioactive agent, a microarray scanning device to detect an interaction between the bioactive agent and the analyte in the bodily fluid; and an interface device.

US Patent:

8158430, Apr 17, 2012

Filed:

Aug 6, 2008

Appl. No.:

12/221816

Inventors:

Shaunak Roy - San Mateo CA, US
Malissa Takahashi - Sunnyvale CA, US
Ian Gibbons - Portola Valley CA, US
Edmond Ku - Sunnyvale CA, US
Thanh Dang - San Jose CA, US
Tammy Burd - San Jose CA, US
Adam Vollmer - San Francisco CA, US
Elizabeth A. Holmes - Palo Alto CA, US

Assignee:

Theranos, Inc. - Palo Alto CA

International Classification:

G01N 31/00

US Classification:

436 16, 436150, 4352852, 427 10

Abstract:

The present invention provides fluidic devices and systems that allow detection of analytes from a biological fluid. The methods and devices are particularly useful for providing point-of-care testing for a variety of medical applications.

US Patent:

8202697, Jun 19, 2012

Filed:

Aug 12, 2005

Appl. No.:

11/202231

Inventors:

Elizabeth A. Holmes - Burlingame CA, US

Assignee:

Theranos, Inc. - Palo Alto CA

International Classification:

G01N 33/53

US Classification:

435 71

Abstract:

The invention relates to an ingestible, implantable or wearable medical device comprising a microarray which comprises a bioactive agent capable of interacting with a disease marker biological analyte; a reservoir which comprises at least one therapeutic agent and is capable of releasing the therapeutic agent(s) from the medical device; and a plurality of microchips comprising a microarray scanning device capable of obtaining physical parameter data of an interaction between the disease marker biological analyte with the bioactive agent; a biometric recognition device capable of comparing the physical parameter data with an analyte interaction profile; optionally a therapeutic agent releasing device capable of controlling release of the therapeutic agent from the reservoirs; an interface device capable of facilitating communications between the microarray scanning device, biometric recognition device and the therapeutic agent releasing device; and an energy source to power the medical device. Specifically, the invention relates to a medical device capable of detecting an analyte in a bodily fluid comprising at least one microneedle capable of obtaining a sample of a bodily fluid, a first microchannel through which the sample flows and is in fluid communication with the at least one microneedle, a second microchannel in fluid communication with the first microchannel, through which a buffer flows, wherein the second channel comprises a microarray with a bioactive agent, a microarray scanning device to detect an interaction between the bioactive agent and the analyte in the bodily fluid; and an interface device.

US Patent:

8283155, Oct 9, 2012

Filed:

Oct 8, 2009

Appl. No.:

12/576197

Inventors:

Elizabeth A. Holmes - Palo Alto CA, US
Shaunak Roy - San Mateo CA, US
John Howard - Saratoga CA, US
Chengwang Wang - Palo Alto CA, US
Ian Gibbons - Portola Valley CA, US
Timothy M. Kemp - San Jose CA, US
Shize Daniel Qi - Arcadia CA, US

Assignee:

Theranos, Inc. - Palo Alto CA

International Classification:

C12Q 3/00
C12M 1/36
G01N 35/00
G01N 21/00
G01N 33/00

US Classification:

4352861, 435 3, 435 4, 436 43, 436 50, 422 50, 422403, 422 681, 422 8205, 422500

Abstract:

This invention is in the field of medical devices. Specifically, the present invention provides portable medical devices that allow real-time detection of analytes from a biological fluid. The methods and devices are particularly useful for providing point-of-care testing for a variety of medical applications.