Elizabeth J Holmes

US Patent:

8101402, Jan 24, 2012

Filed:

Aug 12, 2005

Appl. No.:

11/202206

Inventors:

Elizabeth A. Holmes - Burlingame CA, US

Assignee:

Theranos, Inc. - Palo Alto CA

International Classification:

C12M 3/00

US Classification:

4352872

Abstract:

The invention relates to an ingestible, implantable or wearable medical device comprising a microarray which comprises a bioactive agent capable of interacting with a disease marker biological analyte; a reservoir which comprises at least one therapeutic agent and is capable of releasing the therapeutic agent(s) from the medical device; and a plurality of microchips comprising a microarray scanning device capable of obtaining physical parameter data of an interaction between the disease marker biological analyte with the bioactive agent; a biometric recognition device capable of comparing the physical parameter data with an analyte interaction profile; optionally a therapeutic agent releasing device capable of controlling release of the therapeutic agent from the reservoirs; an interface device capable of facilitating communications between the microarray scanning device, biometric recognition device and the therapeutic agent releasing device; and an energy source to power the medical device. Specifically, the invention relates to a medical device capable of detecting an analyte in a bodily fluid comprising at least one microneedle capable of obtaining a sample of a bodily fluid, a first microchannel through which the sample flows and is in fluid communication with the at least one microneedle, a second microchannel in fluid communication with the first microchannel, through which a buffer flows, wherein the second channel comprises a microarray with a bioactive agent, a microarray scanning device to detect an interaction between the bioactive agent and the analyte in the bodily fluid; and an interface device.

US Patent:

8158430, Apr 17, 2012

Filed:

Aug 6, 2008

Appl. No.:

12/221816

Inventors:

Shaunak Roy - San Mateo CA, US
Malissa Takahashi - Sunnyvale CA, US
Ian Gibbons - Portola Valley CA, US
Edmond Ku - Sunnyvale CA, US
Thanh Dang - San Jose CA, US
Tammy Burd - San Jose CA, US
Adam Vollmer - San Francisco CA, US
Elizabeth A. Holmes - Palo Alto CA, US

Assignee:

Theranos, Inc. - Palo Alto CA

International Classification:

G01N 31/00

US Classification:

436 16, 436150, 4352852, 427 10

Abstract:

The present invention provides fluidic devices and systems that allow detection of analytes from a biological fluid. The methods and devices are particularly useful for providing point-of-care testing for a variety of medical applications.

US Patent:

8202697, Jun 19, 2012

Filed:

Aug 12, 2005

Appl. No.:

11/202231

Inventors:

Elizabeth A. Holmes - Burlingame CA, US

Assignee:

Theranos, Inc. - Palo Alto CA

International Classification:

G01N 33/53

US Classification:

435 71

Abstract:

The invention relates to an ingestible, implantable or wearable medical device comprising a microarray which comprises a bioactive agent capable of interacting with a disease marker biological analyte; a reservoir which comprises at least one therapeutic agent and is capable of releasing the therapeutic agent(s) from the medical device; and a plurality of microchips comprising a microarray scanning device capable of obtaining physical parameter data of an interaction between the disease marker biological analyte with the bioactive agent; a biometric recognition device capable of comparing the physical parameter data with an analyte interaction profile; optionally a therapeutic agent releasing device capable of controlling release of the therapeutic agent from the reservoirs; an interface device capable of facilitating communications between the microarray scanning device, biometric recognition device and the therapeutic agent releasing device; and an energy source to power the medical device. Specifically, the invention relates to a medical device capable of detecting an analyte in a bodily fluid comprising at least one microneedle capable of obtaining a sample of a bodily fluid, a first microchannel through which the sample flows and is in fluid communication with the at least one microneedle, a second microchannel in fluid communication with the first microchannel, through which a buffer flows, wherein the second channel comprises a microarray with a bioactive agent, a microarray scanning device to detect an interaction between the bioactive agent and the analyte in the bodily fluid; and an interface device.

US Patent:

20120258472, Oct 11, 2012

Filed:

Mar 30, 2012

Appl. No.:

13/436568

Inventors:

Shaunak Roy - San Mateo CA, US
Malissa Takahashi - Sunnyvale CA, US
Ian Gibbons - Portola Valley CA, US
Edmond Ku - Sunnyvale CA, US
Thanh Dang - San Jose CA, US
Tammy Burd - San Jose CA, US
Adam Vollmer - San Francisco CA, US
Elizabeth A. Holmes - Palo Alto CA, US

International Classification:

G01N 21/76
G01N 30/62

US Classification:

435 79, 73 6161

Abstract:

The present invention provides fluidic devices and systems that allow detection of analytes from a biological fluid. The methods and devices are particularly useful for providing point-of-care testing for a variety of medical applications.

US Patent:

20210223163, Jul 22, 2021

Filed:

Dec 28, 2020

Appl. No.:

17/135437

Inventors:

- Wilmington DE, US
Daniel L. YOUNG - San Francisco CA, US
Elizabeth A. HOLMES - Palo Alto CA, US
Michael SIEGEL - San Francisco CA, US
Ryan WISTORT - San Francisco CA, US

Assignee:

Labrador Diagnostics LLC - Wilmington DE

International Classification:

G01N 21/00
B04B 5/04
B01L 3/02
G01N 33/543
G01N 21/03
G01N 21/51
C12Q 1/42
C12Q 1/48
C12Q 1/6809
C12Q 1/689
G01N 21/59
G01N 33/569
G01N 33/573
G01N 33/74
G01N 33/80
G06T 3/40
G06T 7/00
H04N 5/232
C12Q 1/52
C12Q 1/6806
G01N 1/40
G01N 33/53
G01N 33/82
G01N 33/92
G01N 35/10

Abstract:

The present invention provides systems, devices, and methods for point-of-care and/or distributed testing services. The methods and devices of the invention are directed toward automatic detection of analytes in a bodily fluid. The components of the device can be modified to allow for more flexible and robust use with the disclosed methods for a variety of medical, laboratory, and other applications. The systems, devices, and methods of the present invention can allow for effective use of samples by improved sample preparation and analysis.

US Patent:

20210115496, Apr 22, 2021

Filed:

Oct 9, 2020

Appl. No.:

17/067257

Inventors:

- Healdsburg CA, US
Elizabeth A. Holmes - San Francisco CA, US

International Classification:

C12Q 1/6804
C12Q 1/70
G01N 33/569
G01N 33/68

Abstract:

Methods, devices, systems, and kits for use in detecting and measuring infectious diseases are provided. In particular embodiments, methods, devices, systems, and kits for detecting and measuring Ebola virus, including Ebola Zaire strain virus, are provided. Devices and systems may be used within regions suffering from Ebola or other infections, providing local, rapid, and effective diagnosis of infectious diseases such as Ebola, improving treatment and reducing or preventing spread of such infectious diseases.

US Patent:

20210025866, Jan 28, 2021

Filed:

Aug 11, 2020

Appl. No.:

16/990232

Inventors:

- Healdsburg CA, US
Elizabeth A. Holmes - San Francisco CA, US

International Classification:

G01N 33/483

Abstract:

Devices, systems and methods for optical analysis of cells in microgravity are disclosed.Effective cellular microscopic and image analysis requires placement of cells into a proper focal plane, region, or volume. Such placement often requires immobilization of the cells. Cell settling onto a substrate is often sufficient for cell immobilization; however, no significant settling occurs in microgravity. Cell immobilization in microgravity may be accomplished by treatment of a substrate, the cells, or both effective that the substrate captures and immobilizes the cells for inspection. Cells may be immobilized in microgravity by adhering magnetic particles to the cells and applying a magnetic field. Cells may be placed in a proper location for viewing in microgravity by placing the cells into a small chamber or narrow channel. Centrifugal force may effect cell settling and aid cell immobilization. Proper placement or immobilization of cells aids cellular microscopic and image analysis in microgravity.

US Patent:

20200234804, Jul 23, 2020

Filed:

Dec 12, 2019

Appl. No.:

16/712545

Inventors:

- Healdsburg CA, US
Elizabeth A. Holmes - San Francisco CA, US

International Classification:

G16H 10/40
G01N 35/10
C12Q 1/70
G01N 33/569
C12Q 1/6895
C12Q 1/6893
C12Q 1/689

Abstract:

Systems, methods, and devices for detecting infections in a clinical sample are provided. Small-volume clinical samples obtained at a point-of-service (POS) location and may be tested at the POS location for multiple markers for multiple diseases, including upper and lower respiratory diseases. Samples may be tested for cytokines, or for inflammation indicators. Dilution of samples, or levels of detection, may be determined by the condition or past history of a subject. Test results may be obtained within a short amount of time after sample placement in a testing device, or within a short amount of time after being obtained from the subject. A prescription for treatment of a detected disorder may be provided, and may be filled, at the POS location. A bill may be automatically generated for the testing, or for the prescription, may be automatically sent to an insurance provider, and payment may be automatically obtained.