Elizabeth K Singer

US Patent:

7314916, Jan 1, 2008

Filed:

Apr 19, 2006

Appl. No.:

11/406679

Inventors:

Elizabeth Singer - Duarte CA, US
Ralf Landgraf - Van Nuys CA, US
Dennis J. Slamon - Woodland Hills CA, US
David Eisenberg - Los Angeles CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

C07K 14/00
C07K 17/00

US Classification:

530350, 530402

Abstract:

The disclosure provided herein identifies and characterizes the domain in HER3 receptor that interacts with heregulin ligand. Typical embodiments of the invention disclosed herein include HER3 variant polypeptides having amino acid sequences which differ from the native HER3 polypeptide sequence and which have altered affinities for heregulin. Also disclosed herein are methods and materials for identifying compounds that bind to the heregulin binding domain in HER3 as well as methods and materials for modulating the interaction between HER3 and heregulin.

US Patent:

7125680, Oct 24, 2006

Filed:

Jul 29, 2002

Appl. No.:

10/207498

Inventors:

Elizabeth Singer - Duarte CA, US
Ralf Landgraf - Van Nuys CA, US
Dennis J. Slamon - Woodland Hills CA, US
David Eisenberg - Los Angeles CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

G01N 33/53

US Classification:

435 72, 435 71, 435 721, 530350

Abstract:

The disclosure provided herein identifies and characterizes the domain in HER3 receptor that interacts with heregulin ligand. Typical embodiments of the invention disclosed herein include methods for identifying compounds which specifically bind the heregulin binding domain in HER3.