Michael W. Berns - Bonsall CA, US Elliot L. Botvinick - Carlsbad CA, US Craig Rappaport - San Marcos CA, US
Assignee:
The Regents of the University of California - Oakland CA
International Classification:
G02B 21/00
US Classification:
359384, 359665
Abstract:
A microscope fluid applicator includes an immersion fluid reservoir for storing immersion fluid and an applicator tip coupled to the immersion fluid reservoir. The microscope fluid applicator is releasably engaged to a moveable turret on a microscope. The microscope fluid applicator may be secured to an objective lens port on a turret of a microscope via threads. Immersion fluid is ejected from the applicator tip onto a sample holder. The turret may be rotated to place an immersion fluid objective into the immersion fluid. The sample may then be viewed through the immersion fluid. Any excess immersion fluid that is dispensed from the applicator tip may be collected in a fluid collector to prevent contamination of the microscope optics and other components.
Provided herein is a stabilized oxygen transport matrix that includes a reversible oxygen binding protein, such as hemoglobin, immobilized throughout the stabilized oxygen transport matrix. The stabilized oxygen transport matrix is used to transport oxygen and can be used as an oxygen transport region and a reaction region of an analyte sensor, such as an implantable glucose sensor. The reversible binding protein can also function as an oxygen probe within the analyte sensor.
Elliot Botvinick - Carlsbad CA, US Troy Bremer - Dana Point CA, US
International Classification:
A61B005/00 A61B005/05
US Classification:
600347000, 600316000, 600342000
Abstract:
Provided herein is a stabilized oxygen transport matrix that includes a reversible oxygen binding protein, such as hemoglobin, immobilized throughout the stabilized oxygen transport matrix. The stabilized oxygen transport matrix is used to transport oxygen and can be used as an oxygen transport region and a reaction region of an analyte sensor, such as an implantable glucose sensor. The reversible binding protein can also function as an oxygen probe within the analyte sensor.
Systems And Methods For Identifying And Disrupting Cellular Organelles
Michael W. Berns - Irvine CA, US Thoru Pederson - Worchester MA, US Elliot Botvinick - Irvine CA, US Linda Zhixia Shi - Vista CA, US
Assignee:
The Regents of the University of California - Oakland CA
International Classification:
C12Q 1/68 C12Q 1/02
US Classification:
435 61, 435 29
Abstract:
This invention relates to optomechanical systems and methods for altering, modifying or disrupting a target object. Such systems and methods are used for, for example, ablating the endogenous nucleus in a cell.
Concentration Independent Modulation Of Local Micromechanics In A Fibrin Gel
Elliot Botvinick - Irvine CA, US Samir Shreim - Irvine CA, US Maxwell Kotlarchyk - Costa Mesa CA, US
Assignee:
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA - Oakland CA
International Classification:
G01N 3/24
US Classification:
73843
Abstract:
An apparatus and method for providing a gradient strain to an extracellular matrix to induce mechanotransduction. The gradient strain can be produced by adhering the extracellular matrix to a post and the walls of a sample holder, and then rotating the post and the sample holder. This strain can result in increased stiffness of the extracellular matrix with very little loss of pore size.
A composite material for detecting and measuring levels of analytes and target molecules in biological fluid and tissue is disclosed herein. This composite material is constructed from a porous mesh sheet that is coated with a signal emitting material and is impregnated with target detecting molecules mixed inside one or multiple polymer mixtures. The geometry and configuration of different constituents can provide high efficiency of signals, the ability to measure multiple signals, small dimensions, fast response to changes, long storage lifetimes, controlled diffusional and mechanical properties, as well as easy industrial manufacturability. The composite material can be used in many sensing applications including optical or electrochemical continuous biosensing such as continuous glucose and lactate monitors.
- Oakland CA, US Luciano Groisman - Irvine CA, US Ali Mohraz - Irvine CA, US Elliot L. Botvinick - Irvine CA, US
International Classification:
A61L 31/14 A61M 5/158 A61M 25/00
Abstract:
Infusion sets for subcutaneous drug delivery are described herein. The infusion set integrates a bijel-templated material (BTM) into a cannula such that a portion of the BTM protrudes from the cannula tip into the host tissue. The BTM is a porous, polymeric sponge having a co-continuous architecture with consistent curvature throughout non-constricting, interpenetrating channels, which is critical in mitigation of the deleterious host tissue response, vascularization, and flow redistribution in the implant.
Self-Assembly Derived Co-Continuous Materials For Biomedical Devices
- Oakland CA, US Todd J. Thorson - Irvine CA, US Elliot L. Botvinick - Irvine CA, US
International Classification:
A61L 27/34 A61L 27/52
Abstract:
A method and material composition of a highly porous material that is applied to an object, such as a biomaterial implant and biomedical device, is described. The method involves forming a bijel mixture that is exposed to at least an outer surface of an object. Thereafter, a precursor is added to the bijel mixture to allow the precursor to transport into a particular liquid phase of the bijel mixture. After at least partial transport, the precursor-containing liquid phase of the bijel mixture is solidified to form a bijel-templated material (BTM) that is bonded to a surface of the object.