Elliot L Botvinick

US Patent:

7532393, May 12, 2009

Filed:

Jun 20, 2006

Appl. No.:

11/425336

Inventors:

Michael W. Berns - Bonsall CA, US
Elliot L. Botvinick - Carlsbad CA, US
Craig Rappaport - San Marcos CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

G02B 21/00

US Classification:

359384, 359665

Abstract:

A microscope fluid applicator includes an immersion fluid reservoir for storing immersion fluid and an applicator tip coupled to the immersion fluid reservoir. The microscope fluid applicator is releasably engaged to a moveable turret on a microscope. The microscope fluid applicator may be secured to an objective lens port on a turret of a microscope via threads. Immersion fluid is ejected from the applicator tip onto a sample holder. The turret may be rotated to place an immersion fluid objective into the immersion fluid. The sample may then be viewed through the immersion fluid. Any excess immersion fluid that is dispensed from the applicator tip may be collected in a fluid collector to prevent contamination of the microscope optics and other components.

US Patent:

8543182, Sep 24, 2013

Filed:

Jun 29, 2006

Appl. No.:

11/427641

Inventors:

Elliot Botvinick - Carlsbad CA, US
Troy M. Bremer - Dana Point CA, US

Assignee:

Metronom Health, Inc. - Laguna Hills CA

International Classification:

A61B 5/00
G01F 1/64
C12Q 1/00
C12Q 1/54

US Classification:

600345, 600346, 600347, 600365, 600357, 600360, 205792, 205778, 435 4, 435 14

Abstract:

Provided herein is a stabilized oxygen transport matrix that includes a reversible oxygen binding protein, such as hemoglobin, immobilized throughout the stabilized oxygen transport matrix. The stabilized oxygen transport matrix is used to transport oxygen and can be used as an oxygen transport region and a reaction region of an analyte sensor, such as an implantable glucose sensor. The reversible binding protein can also function as an oxygen probe within the analyte sensor.

US Patent:

20050177035, Aug 11, 2005

Filed:

Dec 16, 2004

Appl. No.:

11/013997

Inventors:

Elliot Botvinick - Carlsbad CA, US
Troy Bremer - Dana Point CA, US

International Classification:

A61B005/00
A61B005/05

US Classification:

600347000, 600316000, 600342000

Abstract:

Provided herein is a stabilized oxygen transport matrix that includes a reversible oxygen binding protein, such as hemoglobin, immobilized throughout the stabilized oxygen transport matrix. The stabilized oxygen transport matrix is used to transport oxygen and can be used as an oxygen transport region and a reaction region of an analyte sensor, such as an implantable glucose sensor. The reversible binding protein can also function as an oxygen probe within the analyte sensor.

US Patent:

20120129158, May 24, 2012

Filed:

Sep 16, 2011

Appl. No.:

13/234986

Inventors:

Michael W. Berns - Irvine CA, US
Thoru Pederson - Worchester MA, US
Elliot Botvinick - Irvine CA, US
Linda Zhixia Shi - Vista CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

C12Q 1/68
C12Q 1/02

US Classification:

435 61, 435 29

Abstract:

This invention relates to optomechanical systems and methods for altering, modifying or disrupting a target object. Such systems and methods are used for, for example, ablating the endogenous nucleus in a cell.

US Patent:

20120272745, Nov 1, 2012

Filed:

Apr 26, 2012

Appl. No.:

13/457342

Inventors:

Elliot Botvinick - Irvine CA, US
Samir Shreim - Irvine CA, US
Maxwell Kotlarchyk - Costa Mesa CA, US

Assignee:

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA - Oakland CA

International Classification:

G01N 3/24

US Classification:

73843

Abstract:

An apparatus and method for providing a gradient strain to an extracellular matrix to induce mechanotransduction. The gradient strain can be produced by adhering the extracellular matrix to a post and the walls of a sample holder, and then rotating the post and the sample holder. This strain can result in increased stiffness of the extracellular matrix with very little loss of pore size.

US Patent:

20210315492, Oct 14, 2021

Filed:

Feb 17, 2021

Appl. No.:

17/177570

Inventors:

- Oakland CA, US
John Weidling - Irvine CA, US
Elliot L. Botvinick - Irvine CA, US

International Classification:

A61B 5/1459
C08J 3/20
C08F 14/26
C09K 11/06
C08F 2/50
A61B 5/145
A61B 5/1473

Abstract:

A composite material for detecting and measuring levels of analytes and target molecules in biological fluid and tissue is disclosed herein. This composite material is constructed from a porous mesh sheet that is coated with a signal emitting material and is impregnated with target detecting molecules mixed inside one or multiple polymer mixtures. The geometry and configuration of different constituents can provide high efficiency of signals, the ability to measure multiple signals, small dimensions, fast response to changes, long storage lifetimes, controlled diffusional and mechanical properties, as well as easy industrial manufacturability. The composite material can be used in many sensing applications including optical or electrochemical continuous biosensing such as continuous glucose and lactate monitors.

US Patent:

20210252196, Aug 19, 2021

Filed:

Jan 16, 2019

Appl. No.:

16/972972

Inventors:

- Oakland CA, US
Luciano Groisman - Irvine CA, US
Ali Mohraz - Irvine CA, US
Elliot L. Botvinick - Irvine CA, US

International Classification:

A61L 31/14
A61M 5/158
A61M 25/00

Abstract:

Infusion sets for subcutaneous drug delivery are described herein. The infusion set integrates a bijel-templated material (BTM) into a cannula such that a portion of the BTM protrudes from the cannula tip into the host tissue. The BTM is a porous, polymeric sponge having a co-continuous architecture with consistent curvature throughout non-constricting, interpenetrating channels, which is critical in mitigation of the deleterious host tissue response, vascularization, and flow redistribution in the implant.

US Patent:

20200139009, May 7, 2020

Filed:

Jun 8, 2018

Appl. No.:

16/625213

Inventors:

- Oakland CA, US
Todd J. Thorson - Irvine CA, US
Elliot L. Botvinick - Irvine CA, US

International Classification:

A61L 27/34
A61L 27/52

Abstract:

A method and material composition of a highly porous material that is applied to an object, such as a biomaterial implant and biomedical device, is described. The method involves forming a bijel mixture that is exposed to at least an outer surface of an object. Thereafter, a precursor is added to the bijel mixture to allow the precursor to transport into a particular liquid phase of the bijel mixture. After at least partial transport, the precursor-containing liquid phase of the bijel mixture is solidified to form a bijel-templated material (BTM) that is bonded to a surface of the object.