Emanuela S Andreescu

US Patent:

20120315659, Dec 13, 2012

Filed:

Jun 9, 2011

Appl. No.:

13/156755

Inventors:

Emanuela Silvana Andreescu - Potsdam NY, US
Maryna Ornatska - Potsdam NY, US
Cristina R. Ispas - Brea CA, US
Daniel Andreescu - Potsdam NY, US

Assignee:

Clarkson University - Potsdam NY

International Classification:

C12Q 1/26
G01N 21/00
G01N 33/00

US Classification:

435 25, 436135, 436164

Abstract:

A colorimetric reagent in the form of nanoparticles, composite nanoparticles, and nanoparticle coatings, including methods of use, methods of preparation, deposition, and assembly of related devices and specific applications. The colorimetric reagent comprises cerium oxide nanoparticles which are used in solution or immobilized on a solid support, either alone or in conjunction with oxidase enzymes, to form an active colorimetric component that reacts with an analyte to form a colored complex. The rate of color change and the intensity of the color are proportional to the amount of analyte present in the sample. Also described is the use of ceria and doped ceria nanoparticles as an oxygen storage/delivery vehicle for oxidase enzymes and applications in biocatalytic processes in anaerobic conditions of interest in biomedicine and bioanalysis. Further described are a variety of related applications of the disclosed technology including clinical diagnosis, in vivo implantable devices, food safety, and fermentation control.

US Patent:

20100098768, Apr 22, 2010

Filed:

Oct 16, 2009

Appl. No.:

12/580859

Inventors:

Emanuela Silvana Andreescu - Potsdam NY, US
James C. Leiter - Woodstock VT, US
Joseph S. Erlichman - Canton NY, US

Assignee:

CLARKSON UNIVERSITY - Potsdam NY

International Classification:

A61K 9/14
A61K 33/24
A61P 39/00
A61P 9/10

US Classification:

424489, 424649, 424617

Abstract:

A metal oxide nanoparticle composition including a cerium oxide nanoparticle and a metal adapted to enhance the neuroprotective activity of the cerium oxide nanoparticle. The metal can include noble metals such as platinum, and rare earth metals such as gadolinium, samarium, titanium, yttrium, zirconium, and a combination thereof Another metal oxide nanoparticle composition including a cerium oxide nanoparticle and a surface modifier, such as polyethylene oxide, polyethylene imine, dextran, polylactic acid, chitosan, alginate, and a combination thereof is provided. A method of using the metal oxide nanoparticle compositions as neuroprotective agents for the inactivation of reactive oxygen species in nervous tissues is also provided. More specifically, a neuroprotective method using the metal oxides such as ceria, yttria, or mixed ceria and yttria (or any of the other referenced metal oxide nanoparticle compositions) before, during, or after an ischemic event.

US Patent:

20230125201, Apr 27, 2023

Filed:

Oct 25, 2022

Appl. No.:

17/973143

Inventors:

Emanuela Silvana Andreescu - Potsdam NY, US
Abd Ur Rehman - Potsdam NY, US
Daniel Andreescu - Potsdam NY, US

Assignee:

CLARKSON UNIVERSITY - POTSDAM NY

International Classification:

G01N 21/78
G01N 27/48

Abstract:

A method and sensing system for the determination per and poly-fluoroalkyl substances (PFASs) is disclosed, wherein the probe is based on measurement of the redox activity of a redox indicator. The method includes adding a PFAS compound to an indicator solution, gel, 3D printed object, electrode or a sensing surface containing and measuring the change in the indicator signal as a function of PFAS concentration. Further provided is a portable sensor for rapid monitoring of the presence and PFAS concentrations. The present invention includes deposition of the indicator component within a method, assay, apparatus and sensing platform. Further provided is a composite electrode and sensor with binding and signaling activity for a broad range of PFAS, as well as printing ink compositions that incorporate the redox indicator.

US Patent:

20180022604, Jan 25, 2018

Filed:

Jul 24, 2017

Appl. No.:

15/657905

Inventors:

Emanuela Silvana Andreescu - Potsdam NY, US
Ali Othman - Potsdam NY, US

Assignee:

Clarkson University - Potsdam NY

International Classification:

B82Y 40/00
B01J 23/10
B22F 1/00

Abstract:

Device, method, and system for nanoparticle capture, tracking, and/or detection. A functional paper-based platform is modified with capture ligands to create binding sites for nanoparticles. According to an embodiment, nanoparticle binding produces visual images of the particle content and distribution on the modified sensing surface, which provides capabilities for both NP sequestration and real-time detection. According to an embodiment the system may be utilized for environmental decontamination, fabrication of personal protective equipment, field monitoring, and epidemiological studies. The availability of inexpensive and easy-to-use quantitative methods can facilitate rapid assessment and measurement of NPs concentration and the level of exposure for large scale toxicological and epidemiological testing

US Patent:

20140220608, Aug 7, 2014

Filed:

Apr 3, 2014

Appl. No.:

14/244437

Inventors:

Emanuela Silvana Andreescu - Potsdam NY, US
Maryna Ornatska - Potsdam NY, US
Cristina R. Ispas - Brea CA, US
Daniel Andreescu - Potsdam NY, US

Assignee:

CLARKSON UNIVERSITY - Potsdam NY

International Classification:

C12Q 1/60
C12Q 1/54
C12Q 1/26

US Classification:

435 11, 435 25, 435 14, 4352887

Abstract:

A colorimetric reagent in the form of nanoparticles, composite nanoparticles, and nanoparticle coatings, including methods of use, methods of preparation, deposition, and assembly of related devices and specific applications. The colorimetric reagent comprises cerium oxide nanoparticles which are used in solution or immobilized on a solid support, either alone or in conjunction with oxidase enzymes, to form an active colorimetric component that reacts with an analyte to form a colored complex. The rate of color change and the intensity of the color are proportional to the amount of analyte present in the sample. Also described is the use of ceria and doped ceria nanoparticles as an oxygen storage/delivery vehicle for oxidase enzymes and applications in biocatalytic processes in anaerobic conditions of interest in biomedicine and bioanalysis. Further described are a variety of related applications of the disclosed technology including clinical diagnosis, in vivo implantable devices, food safety, and fermentation control.

US Patent:

20140162368, Jun 12, 2014

Filed:

Aug 20, 2013

Appl. No.:

13/971377

Inventors:

Erica Sharpe - Queensbury NY, US
Emanuela Silvana Andreescu - Potsdam NY, US
Daniel Andreescu - Potsdam NY, US

Assignee:

CLARKSON UNIVERSITY - Potsdam NY

International Classification:

G01N 33/02
G01N 33/58

US Classification:

436 20, 422400, 422420

Abstract:

Methods and assay for the portable colorimetric detection of an antioxidant in a food sample. According to one aspect the method comprises the steps of providing a colorimetric reagent comprising a plurality of ceria nanoparticles immobilized to a support, contacting the colorimetric reagent with the food sample, and detecting an optical property of the colorimetric reagent, wherein a change in the optical property of the colorimetric reagent is associated with the presence of antioxidant in the food sample, and further wherein the change in the optical property of the colorimetric reagent is dependent upon the concentration of the antioxidant in said food sample.