Enrico M Mongeau

US Patent:

20130064769, Mar 14, 2013

Filed:

Feb 8, 2011

Appl. No.:

13/577674

Inventors:

Richard R. Cesati - Pepperell MA, US
Edward H. Cheesman - Lunenburg MA, US
Joel Lazewatsky - Auburndale MA, US
Heike S. Radeke - South Grafton MA, US
James F. Castner - Groton MA, US
Enrico Mongeau - Nashua NH, US
Dianne D. Zdankiewicz - Londonderry NH, US
Robert Wilburn Siegler - Chelmsford MA, US
Marybeth Devine - Greensville OH, US

Assignee:

Lantheus Medical Imaging, Inc - North Billerica MA

International Classification:

A61K 51/04
B01J 19/00
C07D 237/16

US Classification:

424 189, 544224, 422310

Abstract:

The present invention generally relates to methods and system for the synthesis of imaging agents, and precursors thereof. The methods may exhibit improved yields and may allow for the large-scale synthesis of imaging agents, including imaging agents comprising a radioisotope (e.g., F). Various embodiments of the invention may be useful as sensors, diagnostic tools, and the like. In some cases, methods for evaluating perfusion, including myocardial perfusion, are provided. Synthetic methods of the invention have also been incorporated into an automated synthesis unit to prepare and purify imaging agents that comprise a radioisotope. In some embodiments, the present invention provides a novel methods and systems comprising imaging agent 1, including methods of imaging in a subject comprising administering a composition comprising imaging agent 1 to a subject by injection, infusion, or any other known method, and imaging the area of the subject wherein the event of interest is located.

US Patent:

20190290788, Sep 26, 2019

Filed:

Feb 21, 2018

Appl. No.:

15/901286

Inventors:

- Norh Billerica MA, US
Enrico Mongeau - Nashua NH, US
Dianne D. Zdankiewicz - Londonderry NH, US
Robert W. Siegler - Chelmsford MA, US
Richard R. Casati - Pepperell MA, US

Assignee:

Lantheus Medical Imaging, Inc. - North Billerica MA

International Classification:

A61K 51/04
C07D 237/16
C07D 407/12

Abstract:

The present invention generally relates to methods and system for the synthesis of imaging agents, and precursors thereof. The methods may exhibit improved yields and may allow for the large-scale synthesis of imaging agents, including imaging agents comprising a radioisotope (e.g., F). Various embodiments of the invention may be useful as sensors, diagnostic tools, and the like. In some cases, methods for evaluating perfusion, including myocardial perfusion, are provided. Synthetic methods of the invention have also been incorporated into an automated synthesis unit to prepare and purify imaging agents that comprise a radioisotope. In some embodiments, the present invention provides a novel methods and systems comprising imaging agent , including methods of imaging in a subject comprising administering a composition comprising imaging agent to a subject by injection, infusion, or any other known method, and imaging the area of the subject wherein the event of interest is located.

US Patent:

20170258947, Sep 14, 2017

Filed:

Feb 15, 2017

Appl. No.:

15/433387

Inventors:

- North Billerica MA, US
Edward H. Cheesman - Lunenburg MA, US
Joel Lazewatsky - Auburndale MA, US
Heike S. Radeke - South Grafton MA, US
Enrico Mongeau - Nashua NH, US
Dianne D. Zdankiewicz - Londonderry NH, US
Marybeth Devine - Greensville OH, US

Assignee:

Lantheus Medical Imaging, Inc. - North Billerica MA

International Classification:

A61K 51/04
C07D 407/12
C07D 237/16

Abstract:

The present invention generally relates to methods and system for the synthesis of imaging agents, and precursors thereof. The methods may exhibit improved yields and may allow for the large-scale synthesis of imaging agents, including imaging agents comprising a radioisotope (e.g., F). Various embodiments of the invention may be useful as sensors, diagnostic tools, and the like. In some cases, methods for evaluating perfusion, including myocardial perfusion, are provided. Synthetic methods of the invention have also been incorporated into an automated synthesis unit to prepare and purify imaging agents that comprise a radioisotope. In some embodiments, the present invention provides a novel methods and systems comprising imaging agent 1, including methods of imaging in a subject comprising administering a composition comprising imaging agent 1 to a subject by injection, infusion, or any other known method, and imaging the area of the subject wherein the event of interest is located.