Eric I Block

US Patent:

6495125, Dec 17, 2002

Filed:

Jan 5, 2001

Appl. No.:

09/755817

Inventors:

Robert Wayne Glenn, Jr. - Surrey, GB
Alan Roy Katritzky - Gainesville FL
Eric Block - Niskayuna NY
Matthew David Shair - Boston MA
Thomas Ehlis - Freiburg, DE
Joseph Anthony Lupia - Colfax NC

Assignee:

The Procter Gamble Company - Cincinnati OH

International Classification:

A61K 706

US Classification:

424 709, 424 701, 424401, 424544, 424316

Abstract:

This invention relates to a topical composition for treating amino acid based substrates comprising a protected thiol compound having the formula where R is a functional group, S is sulfur, and Pr is a heterocyclic protecting group, and m is an integer between 1 and 100. The invention further relates to systems which comprise this protected thiol compound and an activating mechanism. The protected thiol compounds of the present invention may be used in hair care compositions, textile care compositions, cosmetic compositions, oral care compositions, skin care, nail care, laundry care, acne care and animal care compositions. Preferred embodiments of the present invention provide a modified UV absorber and a modified antioxidant, methods for making them and compositions conprising them.

US Patent:

6544499, Apr 8, 2003

Filed:

Jan 7, 2000

Appl. No.:

09/478855

Inventors:

Robert Wayne Glenn, Jr. - Virginia Water, GB
Alan Roy Katritzky - Gainesville FL
Eric Block - Niskayuna NY
Matthew David Shair - Boston MA
Matthew David Butts - Rexford NY

Assignee:

The Procter Gamble Company - Cincinnati OH

International Classification:

A61K 706

US Classification:

424 701, 424400, 424401, 424 702

Abstract:

This invention relates to a topical composition for treating amino acid based substrates comprising a protected thiol compound having the formula where R is a functional group, S is sulfur, and Pr is a heterocyclic protecting group, and m is an integer between 1 and 100. The invention further relates to systems which comprise this protected thiol compound and an activating mechanism. The protected thiol compounds of the present invention may be used in hair care compositions, textile care compositions, cosmetic compositions, oral care compositions, skin care, nail care, laundry care, acne care and animal care compositions. A preferred embodiment of the present invention provides a silicone composition and method for making. The composition comprises a polysiloxane or silicone resin, at least one linker, and at least one molecular hook.

US Patent:

8101802, Jan 24, 2012

Filed:

Nov 12, 2007

Appl. No.:

12/514370

Inventors:

Murree Groom - Thetford, GB
Eric Block - Niskayuna NY, US

Assignee:

ECOspray Limited - Norfolk

International Classification:

C07C 321/00
C07C 323/00

US Classification:

568 21, 568 22, 568 24, 568 25, 556428

Abstract:

Diallylic polysulfides (polysulfanes) are provided with sulfur chain lengths of 9 to 22. Also provided are bis(2-methyl-2-propenyl) polysulfides with sulfur chain lengths of 3 to 22. Also provided are 2-substituted bis(2-propenyl) polysulfides with sulfur chain lengths of 3 to 20. Also provided are the 2-cycloalken-1-yl polysulfides, 2-cyclohexen-1-yl polysulfides and 2-cyclopenten-1-yl polysulfides, with sulfur chain lengths of 3 to 20. Also provided are processes for extending the sulfur chain length of diallylic polysulfides and 2-substituted analogues thereof and allyl methyl polysulfides by bringing such compounds into contact with elemental sulfur and heating, or by mixing with molten sulfur.

US Patent:

20100069674, Mar 18, 2010

Filed:

Nov 9, 2007

Appl. No.:

12/514171

Inventors:

Murree Groom - Thetford, GB
Eric Block - Niskayuna NY, US

International Classification:

C07C 321/12
C07C 315/00

US Classification:

564500, 568 18

Abstract:

A method of producing polysulfides comprising the step of adding elemental sulphur to an allicin-containing plant extract. In preferred embodiments, the plant extract is mechanically treated members of the genus , especially garlic. In further preferred aspects of the invention, the plant extract and sulphur mixture is heated, and the pH is controlled to allow manipulation of the polysulfide chain length. The addition of organic bases, containing nitrogen lone pairs, allows further control of polysulfide chain length.

US Patent:

20100080843, Apr 1, 2010

Filed:

Jun 30, 2006

Appl. No.:

11/428194

Inventors:

Shaker Mousa - Wynantskill NY, US
Eric Block - Niskayuna NY, US

Assignee:

The Research Foundation of the State University Of New York at Albany - Albany NY

International Classification:

A61K 31/38
A61K 31/381
A61K 31/10
A61K 31/095
A61K 9/127
A61P 35/00

US Classification:

424450, 514430, 514446, 514709, 514706

Abstract:

The present invention relates to inhibiting angiogenesis with sulfur- or selenium-containing compounds, and polymeric forms thereof, in mammals including animals and humans. Sulfur- or selenium-containing compounds, and polymeric forms thereof, can be used alone or in combination with standard therapies to inhibit angiogenesis-mediated disorders. The present invention also relates to the combined use of sulfur- or selenium-containing compounds, and polymeric forms thereof, with other anti-angiogenesis agents, with various anti-inflammatory and cytotoxic agents as well as with radio-therapeutic agents in cancer, and with laser, photodynamic therapy for ocular-related disorders such as diabetic retinopathy or age-related macular degeneration.

US Patent:

46044809, Aug 5, 1986

Filed:

Aug 15, 1983

Appl. No.:

6/523276

Inventors:

Eric Block - Delmar NY
Mohammad Aslam - Menands NY

Assignee:

The Research Foundation of State University of New York - Albany NY

International Classification:

C07F 704
C07C 276

US Classification:

556445

Abstract:

A method for the preparation of a first sulfone compound of the formula: ##STR1## wherein R. sub. a is ##STR2## where R. sub. b is Br and R. sub. c is H except that R. sub. b and R. sub. c together may be an electron pair when R. sub. 6 is a radical of the formula: ##STR3## wherein X. sub. 1 is independently chlorine, bromine or iodine and R. sub. 1 and R. sub. 2 are independently at each occurrence hydrogen or, substituted or unsubstituted, phenyl or alkyl where the substituents are halogen or alkoxy or additional --SO. sub. 2 Br groups; provided that, each carbon atom of R. sub. 1 or R. sub. 2 which contains --SO. sub. 2 Br also contains an X. sub. 1 group and wherein R. sub. 3 through R. sub. 9 are independently --OZ,--C. sub. 6 M. sub. 5,--Z,--SiZ. sub. 3 or --X. sub.

US Patent:

46439943, Feb 17, 1987

Filed:

Dec 17, 1984

Appl. No.:

6/682435

Inventors:

Eric Block - Delmar NY
Saleem Ahmad - Albany NY

Assignee:

The Research Foundation of State University of New York - Albany NY

International Classification:

A61K 3160
C07C14912

US Classification:

514165

Abstract:

This invention relates to novel organic trithio oxides of the formula: R. sup. 1 --X --R--X. sup. 1 --R. sup. 1 wherein R is selected from --CH. sub. 2 CH. dbd. CH--, ##STR1## and (CH. sub. 2). sub. 3 ; X is selected from ##STR2## X. sup. 1 is selected from --S--S, ##STR3## and, each R. sup. 1 is independently selected from carboxyalkyl, alkoxy, alkylthio, amino, alkylamino and acyl substituted and unsubstituted lower alkyl, lower alkenyl, lower alkynyl, phenyl and lower alkylphenyl; provided when R is --CH. sub. 2 CH. dbd. CH--, X is ##STR4## and X. sup. 1 is --S--S--, then R. sup. 1 is not in both instances --CH. sub. 2 CH. dbd. CH. sub. 2. This invention also relates to a method of preparing the above-identified compounds by heating and further oxidizing various oxides of organic disulfides and to antithrombotic uses of the compounds.

US Patent:

54789591, Dec 26, 1995

Filed:

Oct 5, 1994

Appl. No.:

8/318504

Inventors:

Eric Block - Schenectady NY
Chuangxing Guo - West Lafayette IN

Assignee:

The Research Foundation of State University of New York - Albany NY

International Classification:

C07F 722
C07C32718
C07C32305
C07C32322

US Classification:

556 87

Abstract:

A method for preparing 1,4-(Z,Z)-disubstituted-1,4-disulfurated-1,3-butadienes is disclosed. The butadienes can be further elaborated to provide 3,6-unsymmetrically-substituted-1,2-dithiins. Also disclosed are butadienes prepared by the method of the invention. These butadienes are useful as intermediates in the synthesis of antibiotic 1,2-dithiins.