The invention provides novel combination therapies for treating neurodegenerative disease which comprise a) neurotrophic factors or suitable fragments thereof and b) agents capable of causing inhibition of a gene responsible for the neurodegenerative disease. The invention provides novel nucleic acid sequences, methods, and systems suitable for applications of these combination therapies.
Suppression Of Scn9A Gene Expression And/Or Function For The Treatment Of Pain
Disclosed herein are methods, sequences and nucleic acid molecules used to treat pain. Specifically, the methods and sequences include locally administering molecules that suppress the expression of amino acid sequences that encode for Na1. 7 channels or that otherwise inhibit the function of Na1. 7 channels. Local suppression of Na1. 7 channel levels and/or function will occur in the peripheral sensory neurons of the dorsal root ganglia.
Compositions And Methods For Making Therapies Delivered By Viral Vectors Reversible For Safety And Allele-Specificity
William F. Kaemmerer - Edina MN, US Eric Burright - Eagan MN, US Deepak Ramesh Thakker - Blaine MN, US Jennifer Heisel - Princeton MN, US
Assignee:
Medtronic, Inc. - Minneapolis MN
International Classification:
C07H 21/04
US Classification:
536 245, 536 2431, 536 241, 514 44
Abstract:
The present invention is directed to compositions, methods and kits for regulation of gene therapies for Huntington's Disease, including, without limitation, reversible gene therapies and allele-specific therapies.
Methods And Devices For Improved Efficiency Of Rna Delivery To Cells
Deepak Ramesh Thakker - Blaine MN, US Carl A. Schu - Plymouth MN, US Eric Neal Burright - Eagan MN, US Paul W. Wacnik - Pittsburgh PA, US Jennifer M. Heisel - Princeton MN, US Lothar Krinke - Eden Prairie MN, US
Assignee:
Medtronic, Inc. - Minneapolis MN
International Classification:
C12N 15/11
US Classification:
514 44A
Abstract:
The instant invention provides a method for improving efficiency of RNA delivery to cells. The method comprises applying a low strength electric field to the cells and then after a certain time period, administering the ribonucleic acid sequence to the cells. Devices, kits, and RNA molecules suitable for delivery and devices suitable for practicing the disclosed methods are also provided.
Medical Devices And Methods For Delivering Compositions To Cells
William Kaemmerer - Edina MN, US Eric Burright - Eagan MN, US Erica TenBrock - Roseville MN, US Janelle Blum - St. Paul MN, US Michael Kaytor - Maplewood MN, US
International Classification:
A61K 48/00 A61M 31/00
US Classification:
424093200, 514044000, 604500000
Abstract:
The present invention provides medical devices and methods for delivering compositions to cells. The compositions include an artificial viral vector, and particularly, an artificial adeno-associated virus vector. Such compositions can be useful for delivering the artificial viral vector across the blood-brain barrier.
Methods And Sequences To Suppress Pro-Inflamatory Cytokine Actions Locally To Treat Pain
Eric Burright - Eagan MN, US Rodolfo Padua - Richfield MN, US Peter Schroeder - Minneapolis MN, US Jennifer Christianson - Princeton MN, US Lisa Shafer - Stillwater MN, US
Assignee:
Medtronic, Inc. - Minneapolis MN
International Classification:
A61K 48/00
US Classification:
514044000
Abstract:
Disclosed herein are methods and sequences used to treat pain. Specifically, the methods and sequences include locally administering nucleic acid molecules that suppress the expression of amino acid sequences that encode for pro-inflammatory cytokines and their receptors to treat acute or neuropathic pain associated with sciatica.
Eric Burright - Eagan MN, US Lisa Shafer - Stillwater MN, US Bill McKay - Memphis TN, US John Zanella - Cordova TN, US
Assignee:
MEDTRONIC, INC. - Minneapolis MN
International Classification:
A61M 31/00 A61K 31/00 A61M 37/00 A01N 61/00
US Classification:
604512000, 604093010, 514001000
Abstract:
Disclosed herein are systems and methods for contributing to the local treatment of pain. More specifically, the disclosed systems and methods contribute to the local treatment pain by inhibiting the NFκB family of transcription factors.
Compositions And Methods For Making Therapies Delivered By Viral Vectors Reversible For Safety And Allele-Specificity
William F. Kaemmerer - Edina MN, US Eric Burright - Eagan MN, US Jennifer Heisel - Princeton MN, US Deepak Thakker - Blaine MN, US
International Classification:
A61K 31/70 A61F 2/00 A61P 43/00 A61F 6/06
US Classification:
424430, 424423, 514 44
Abstract:
The present invention is directed to compositions methods and kits for regulation of gene therapies, including, without limitation, reversible gene therapies and allele-specific therapies.
Name / Title
Company / Classification
Phones & Addresses
Eric Burright President
Cgta Research Group Noncommercial Research Organizations, Nsk