Eric A Davidson

US Patent:

45915679, May 27, 1986

Filed:

Aug 8, 1983

Appl. No.:

6/520756

Inventors:

Roy J. Britten - Costa Mesa CA
Eric H. Davidson - Pasadena CA

Assignee:

California Institute of Technology - Pasadena CA

International Classification:

C12M 132
C12M 126
C12Q 168
C12Q 124

US Classification:

435293

Abstract:

A system for the production and maintenance of genomic libraries of recombinant DNA in a fixed geometric array arranged so that such libraries may be accurately replicated and maintained with the same set of individual DNA inserts occupying reproducible locations and comprising, (a) sets of individual bacterial colonies or plaques of bacteriophage which contain inserts of animal or plant DNA and are present in so large a number that there will be a high probability that the complete library will contain each DNA sequence of all of the sequences present in an animal or plant genome; to be established in subarrays which can individually be replicated, (b) a subsystem for picking up inocula from each of a geometric array simultaneously and transferring them to a second similar geometric array, including carrying and aligning means for maintaining a transfer means in superposed relationship with respect and for raising and lowering the transfer means into and out of proximity to said colonies or plaques, and (c) a subsystem for intially establishing such subarrays by transfer from a randomly spread pattern of colonies or plaques of bacteriophage.

US Patent:

45007861, Feb 19, 1985

Filed:

Apr 21, 1982

Appl. No.:

6/370333

Inventors:

Roy J. Britten - Costa Mesa CA
Eric H. Davidson - Pasadena CA

Assignee:

California Institute of Technology - Pasadena CA

International Classification:

G01T 1185

US Classification:

250389

Abstract:

Novel large area spark chamber having a support for carrying a generally planar, radioactive work piece. The spark chamber has a thin window which is either a rigid plastic sheet carrying a thin layer of an electrically conductive material on the surface thereof, or a thin planar piece or film of electrically conductive metal. There is positioned in superposed relationship to the thin window, a layer of semi-conducting glass in spaced-apart relationship from the thin window by a resilient insulating seal to form an enclosed gas retaining chamber. An electrically conducting surface is adhered to the upper surface of the layer of semi-conducting glass. An electrically conductive path is provided between the thin layer of electrically conductive material on the thin window and the electrically conducting surface on said semi-conducting glass. The electrically conductive path includes a high voltage supply and TDCs and ADCs. There are also means for detecting the location of sites of impingement of radiation on the electrically conducting surface of the semi-conducting glass, and means for recording and analyzing the information present on the work piece.

US Patent:

46224670, Nov 11, 1986

Filed:

Dec 17, 1984

Appl. No.:

6/682533

Inventors:

Roy J. Britten - Costa Mesa CA
Eric H. Davidson - Pasadena CA

Assignee:

California Institute of Technology - Pasadena CA

International Classification:

G01T 1185

US Classification:

250389

Abstract:

A system for mapping radioactive specimens comprises an avalanche counter, an encoder, pre-amplifier circuits, sample and hold circuits and a programmed computer. The parallel plate counter utilizes avalanche event counting over a large area with the ability to locate radioactive sources in two dimensions. When a beta ray, for example, enters a chamber, an ionization event occurs and the avalanche effect multiplies the event and results in charge collection on the anode surface for a limited period of time before the charge leaks away. The encoder comprises a symmetrical array of planar conductive surfaces separated from the anode by a dielectric material. The encoder couples charge currents, the amplitudes of which define the relative position of the ionization event. The amplitude of coupled current, delivered to pre-amplifiers, defines the location of the event.

US Patent:

20140234974, Aug 21, 2014

Filed:

Feb 14, 2014

Appl. No.:

14/181280

Inventors:

- Pasadena CA, US
Yong Zhu - Anaheim CA, US
Eric H. Davidson - Pasadena CA, US

Assignee:

CALIFORNIA INSTITUTE OF TECHNOLOGY - Pasadena CA

International Classification:

G06F 19/12
C12N 5/071
C12N 5/0783
C12N 5/077

US Classification:

435467, 435377, 435455, 703 11

Abstract:

Described herein is a gene regulatory network based focused approach to cell transformation. The methods described herein allow for identification of circuit and sub-circuit repertoires for which modification in a starting cell type can result in generation of a transformed cell type in a durable and persistent manner, without requiring potentially deleterious genome modification. The described methods and compositions produced by the methods find widespread application in regenerative medicine applications.