Eric J Gilbert

US Patent:

6391865, May 21, 2002

Filed:

May 1, 2000

Appl. No.:

09/562814

Inventors:

Bahige M. Baroudy - Westfield NJ
John W. Clader - Cranford NJ
Hubert B. Josien - Jersey City NJ
Stuart W. McCombie - Caldwell NJ
Brian A. McKittrick - Bloomfield NJ
Michael W. Miller - Westfield NJ
Bernard R. Neustadt - West Orange NJ
Anandan Palani - Kenilworth NJ
Elizabeth M. Smith - Verona NJ
Ruo Steensma - Weehawken NJ
Jayaram R. Tagat - Westfield NJ
Susan F. Vice - Mountainside NJ
Eric Gilbert - Scotch Plains NJ
Marc A. Labroli - Mount Laurel NJ

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

A01N 5500

US Classification:

514 63, 514 64, 51425211, 51425218, 51425301, 5142531, 51425311, 51425309, 544229, 544295, 544360, 544364

Abstract:

The use of CCR5 antagonists of the formula or a pharmaceutically acceptable salt thereof, wherein R is optionally substituted phenyl, pyridyl, thiophenyl or naphthyl; R is hydrogen or alkyl; R is substituted phenyl, substituted heteroaryl, naphthyl, fluorenyl, diphenylmethyl or optionally substituted phenyl- or heteroaryl-alkyl; R is hydrogen, alkyl, alkoxyalkyl, cycloalkyl, cycloalkylalkyl, or optionally substituted phenyl, phenylalkyl, naphthyl, naphthylalkyl, heteroaryl or heteroarylalkyl; R , R and R are hydrogen or alkyl; R is hydrogen, alkyl or alkenyl; for the treatment of HIV, solid organ transplant rejection, graft v. host disease, arthritis, rheumatoid arthritis, inflammatory bowel disease, atopic dermatitis, psoriasis, asthma, allergies or multiple sclerosis is disclosed, as well as novel compounds, pharmaceutical compositions comprising them, and the combination of CCR5 antagonists of the invention in combination with antiviral agents useful in the treatment of HIV or agents useful in the treatment of inflammatory diseases.

US Patent:

6689765, Feb 10, 2004

Filed:

Jan 30, 2002

Appl. No.:

10/061011

Inventors:

Bahige M. Baroudy - Westfield NJ
John W. Clader - Cranford NJ
Hubert B. Josien - Jersey City NJ
Stuart W. McCombie - Caldwell NJ
Brian A. McKittrick - Bloomfield NJ
Michael W. Miller - Westfield NJ
Bernard R. Neustadt - West Orange NJ
Anandan Palani - Kenilworth NJ
Elizabeth M. Smith - Verona NJ
Ruo Steensma - Weehawken NJ
Jayaram R. Tagat - Westfield NJ
Susan F. Vice - Mountainside NJ
Mark A. Laughlin - Edison NJ
Eric Gilbert - Scotch Plains NJ
Marc A. Labroli - Mount Laurel NJ

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

A61K 31695

US Classification:

514 63, 514 64, 51425212, 51425213, 51425219, 51425301, 5142531, 51425311, 514 2, 514 42, 514 43, 514 45, 514 49, 514220, 514262, 514263

Abstract:

The use of CCR5 antagonists of the formula or a pharmaceutically acceptable salt thereof, wherein R is optionally substituted phenyl, pyridyl, thiophenyl or naphthyl; R is hydrogen or alkyl; R is substituted phenyl, substituted heteroaryl, naphthyl, fluorenyl, diphenylmethyl or optionally substituted phenyl- or heteroaryl-alkyl; R is hydrogen, alkyl, alkoxyalkyl, cycloalkyl, cycloalkylalkyl, or optionally substituted phenyl, phenylalkyl, naphthyl, naphthylalkyl, heteroaryl or heteroarylalkyl; R , R and R are hydrogen or alkyl; R is hydrogen, alkyl or alkenyl; for the treatment of HIV, solid organ transplant rejection, graft v, host disease, arthritis, rheumatoid arthritis, inflammatory bowel disease, atopic dermatitis, psoriasis, asthma, allergies or multiple sclerosis is disclosed, as well as novel compounds, pharmaceutical compositions comprising them, and the combination of CCR5 antagonists of the invention in combination with antiviral agents useful in the treatment of HIV or agents useful in the treatment of inflammatory diseases.

US Patent:

7384944, Jun 10, 2008

Filed:

Sep 23, 2003

Appl. No.:

10/668862

Inventors:

Bahige M. Baroudy - Westfield NJ, US
John W. Clader - Cranford NJ, US
Hubert B. Josien - Jersey City NJ, US
Stuart W. McCombie - Caldwell NJ, US
Brian A. McKittrick - Bloomfield NJ, US
Michael W. Miller - Westfield NJ, US
Bernard R. Neustadt - West Orange NJ, US
Anandan Palani - Kenilworth NJ, US
Elizabeth M. Smith - Verona NJ, US
Ruo Steensma - Weehawken NJ, US
Jayaram R. Tagat - Westfield NJ, US
Susan F. Vice - Mountainside NJ, US
Mark A. Laughlin - Edison NJ, US
Eric Gilbert - Scotch Plains NJ, US
Marc A. Labroli - Mount Laurel NJ, US

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

A61K 31/497

US Classification:

51425214, 51425212, 51425213, 51425219, 51425301, 5142531, 51425311

Abstract:

The use of CCR5 antagonists of the formula.

US Patent:

7700597, Apr 20, 2010

Filed:

Dec 1, 2005

Appl. No.:

11/292264

Inventors:

Eric J. Gilbert - Scotch Plains NJ, US
Michael W. Miller - Scotch Plains NJ, US
Jack D. Scott - Scotch Plains NJ, US
Andrew W. Stamford - Chatham NJ, US
William J. Greenlee - Teaneck NJ, US
Jay Weinstein - Upper Montclair NJ, US

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

A61K 31/497
C07D 241/04
C07D 295/00

US Classification:

51425212, 544358

Abstract:

Compounds of Formula (I):or pharmaceutically acceptable salts, solvates, or esters thereof, are useful in treating diseases or conditions mediated by CBreceptors, such as metabolic syndrome and obesity, neuroinflammatory disorders, cognitive disorders and psychosis, addiction (e. g. , smoking cessation), gastrointestinal disorders, and cardiovascular conditions.

US Patent:

7705153, Apr 27, 2010

Filed:

Feb 2, 2005

Appl. No.:

11/049460

Inventors:

Pauline C. Ting - New Providence NJ, US
Jianhua Cao - Edison NJ, US
Youhao Dong - Edison NJ, US
Eric J. Gilbert - Scotch Plains NJ, US
Ying Huang - Berkeley Heights NJ, US
Joseph M. Kelly - Parlin NJ, US
Stuart McCombie - Caldwell NJ, US
Neng-Yang Shih - Warren NJ, US

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

A61K 31/4709
A61K 31/4725
C07D 215/14

US Classification:

546168, 546146, 514307, 514314

Abstract:

The use of CCR3 antagonists of the formula I.

US Patent:

7750158, Jul 6, 2010

Filed:

Jun 21, 2005

Appl. No.:

11/157510

Inventors:

Bandarpalle B. Shankar - Branchburg NJ, US
Eric Gilbert - Scotch Plains NJ, US
Razia K. Rizvi - Bloomfield NJ, US
Chunli Huang - Springfield NJ, US
Joseph A. Kozlowski - Princeton NJ, US
Stuart McCombie - Caldwell NJ, US
Neng-Yang Shih - Warren NJ, US

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

C07D 221/00
A61K 31/44

US Classification:

546 16, 514278

Abstract:

Compounds of Formula I:.

US Patent:

8114879, Feb 14, 2012

Filed:

Mar 26, 2008

Appl. No.:

12/055900

Inventors:

Bahige M. Baroudy - Westfield NJ, US
John W. Clader - Cranford NJ, US
Hubert B. Josien - Jersey City NJ, US
Stuart W. McCombie - Caldwell NJ, US
Brian A. McKittrick - New Vernon NJ, US
Michael W. Miller - Scotch Plains NJ, US
Bernard R. Neustadt - West Orange NJ, US
Anandan Palani - Bridgewater NJ, US
Elizabeth M. Smith - Verona NJ, US
Ruo Steensma - Weehawken NJ, US
Jayaram R. Tagat - Westfield NJ, US
Susan F. Vice - Mountainside NJ, US
Mark A. Laughlin - Sandy UT, US
Eric Gilbert - Scotch Plains NJ, US
Marc A. Labroli - Morrestown NJ, US

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

A61K 31/497
C07D 403/00

US Classification:

51425218, 51425211, 51425214, 544295

Abstract:

The use of CCR5 antagonists of the formula.

US Patent:

8236805, Aug 7, 2012

Filed:

Sep 22, 2009

Appl. No.:

12/564678

Inventors:

Eric J. Gilbert - Scotch Plains NJ, US
Michael W. Miller - Scotch Plains NJ, US
Jack D. Scott - Scotch Plains NJ, US
Andrew W. Stamford - Chatham NJ, US
William J. Greenlee - Teaneck NJ, US
Jay Weinstein - Upper Montclair NJ, US

Assignee:

Intervet Inc. - Summit NJ
Intervet International B.V. - Boxmeer

International Classification:

A61K 31/497
C07D 403/00

US Classification:

51425301, 544359

Abstract:

Compounds of Formula (I):.