Eric L Jacobson

Address:

9439 W 119 Ter, Overland Park, KS 66213

Phone:

(913)4695767

VIN:

1HGCM56717A217257

Make:

HONDA

Model:

ACCORD

Year:

2007

US Patent:

6565879, May 20, 2003

Filed:

Oct 13, 2000

Appl. No.:

09/687937

Inventors:

Eric C. Luo - Plano TX
Eric C. Jacobson - San Diego CA
Tsung-Min Hsu - San Diego CA

Assignee:

Dermatrends, Inc. - San Diego CA

International Classification:

A61F 1300

US Classification:

424449, 424443, 424445, 424447, 424448, 514946, 514947, 514944

Abstract:

A method is provided for increasing the permeability of skin or mucosal tissue to a topically or transdermally administered pharmacologically or cosmeceutically active peptide, polypeptide or protein. The method involves use of a specified amount of a hydroxide-releasing agent, the amount optimized to increase the flux of the peptide, polypeptide or protein through a body surface while minimizing the likelihood of skin damage, irritation or sensitization. Formulations and drug delivery devices employing hydroxide-releasing agents as permeation enhancers are provided as well.

US Patent:

6582724, Jun 24, 2003

Filed:

Oct 4, 2001

Appl. No.:

09/972008

Inventors:

Tsung-Min Hsu - San Diego CA
Eric C. Jacobson - San Diego CA
Rose C. LoBello - San Diego CA
Eric C. Luo - Plano TX

Assignee:

Dermatrends, Inc. - San Diego CA

International Classification:

A61F 1300

US Classification:

424449, 424443, 424445, 424447, 424448, 424514, 424946, 424947, 424944

Abstract:

A permeation enhancer composition is provided for increasing the permeability of skin or mucosal tissue to topically or transdermally administered pharmacologically or cosmeceutically active agents. The composition is comprised of a hydroxide-releasing agent and a lipophilic co-enhancer such as a fatty alcohol, a fatty ether, or a fatty acid ester, including fatty acid esters of polyols such as propylene glycol and glycerol. Also provided are pharmaceutical formulations containing a therapeutically effective amount of an active agent in addition to the aforementioned enhancer composition, methods for administering active agents topically or transdermally with enhanced permeation, and drug delivery systems for application to an individuals skin or mucosal tissue, wherein the systems are formulated so as to contain an active agent to be administered and an effective permeation enhancing amount of an enhancer composition of the invention.

US Patent:

6586000, Jul 1, 2003

Filed:

Dec 14, 2000

Appl. No.:

09/738410

Inventors:

Eric C. Luo - Plano TX
Eric C. Jacobson - San Diego CA
Tsung-Min Hsu - San Diego CA

Assignee:

Dermatrends, Inc. - San Diego CA

International Classification:

A61F 1300

US Classification:

424449, 424443, 424445, 424447, 424448, 514946, 514947, 514944

Abstract:

A method is provided for increasing the permeability of skin or mucosal tissue to topically or transdermally administered pharmacologically or cosmeceutically active agents. The method involves use of a specified amount of a hydroxide-releasing agent, the amount optimized to increase the flux of the active agent through a body surface while minimizing the likelihood of skin damage, irritation or sensitization. Topically applied formulations and drug delivery devices employing hydroxide-releasing agents as permeation enhancers are provided as well.

US Patent:

6835392, Dec 28, 2004

Filed:

Mar 13, 2003

Appl. No.:

10/389143

Inventors:

Tsung-Min Hsu - San Diego CA
Eric C. Jacobson - San Diego CA
Rose C. LoBello - San Diego CA
Eric C. Luo - Plano TX

Assignee:

Dermatrends, Inc. - San Diego CA

International Classification:

A61F 1300

US Classification:

424449, 424443, 424445, 424447, 424448, 514946, 514944

Abstract:

A permeation enhancer composition is provided for increasing the permeability of skin or mucosal tissue to topically or transdermally administered pharmacologically or cosmeceutically active agents. The composition is comprised of a hydroxide-releasing agent and a lipophilic co-enhancer such as a fatty alcohol, a fatty ether, or a fatty acid ester, including fatty acid esters of polyols such as propylene glycol and glycerol. Also provided are pharmaceutical formulations containing a therapeutically effective amount of an active agent in addition to the aforementioned enhancer composition, methods for administering active agents topically or transdermally with enhanced permeation, and drug delivery systems for application to an individuals skin or mucosal tissue, wherein the systems are formulated so as to contain an active agent to be administered and an effective permeation enhancing amount of an enhancer composition of the invention.

US Patent:

20020192243, Dec 19, 2002

Filed:

Jun 19, 2002

Appl. No.:

10/176264

Inventors:

Tsung-Min Hsu - San Diego CA, US
Eric Jacobson - San Diego CA, US
Eric Luo - Plano TX, US

International Classification:

A61K009/00
A61K009/70

US Classification:

424/400000

Abstract:

Methods are provided for enhancing the permeability of skin or mucosal tissue to topical or transdermal application of a drug for the treatment of Alzheimer's disease. The methods entail the use of a base in order to increase the flux of the drug through a body surface while minimizing the likelihood of skin damage, irritation or sensitization. The permeation enhancer can be an inorganic or organic base. Compositions and transdermal systems are also described.

US Patent:

20020192300, Dec 19, 2002

Filed:

Jun 19, 2002

Appl. No.:

10/175681

Inventors:

Eric Luo - Plano TX, US
Alan Hickey - San Diego CA, US
Eric Jacobson - San Diego CA, US
Tsung-Min Hsu - San Diego CA, US

International Classification:

A61K009/70
A61K033/02
A61K033/00

US Classification:

424/719000, 424/722000

Abstract:

Methods are provided for enhancing the permeability of skin or mucosal tissue to topical or transdermal application of antipsychotic agents. The methods entail the use of a base in order to increase the flux of the agent through a body surface while minimizing the likelihood of skin damage, irritation or sensitization. The permeation enhancer can be an inorganic or organic base. Compositions and transdermal systems are also described.

US Patent:

20020192301, Dec 19, 2002

Filed:

Jun 19, 2002

Appl. No.:

10/175682

Inventors:

Eric Luo - Plano TX, US
Eric Jacobson - San Diego CA, US
Tsung-Min Hsu - San Diego CA, US

International Classification:

A61K033/02
A61K033/00

US Classification:

424/719000, 424/722000

Abstract:

Methods are provided for enhancing the permeability of skin or mucosal tissue to topical or transdermal application of antihypertensive agents. The methods entail the use of a base in order to increase the flux of the agent through a body surface while minimizing the likelihood of skin damage, irritation or sensitization. The permeation enhancer can be an inorganic or organic base. Compositions and transdermal systems are also described.

US Patent:

20030104041, Jun 5, 2003

Filed:

Jun 20, 2002

Appl. No.:

10/177436

Inventors:

Tsung-Min Hsu - San Diego CA, US
Nicole Gricenko - San Diego CA, US
Alan Hickey - San Diego CA, US
Eric Jacobson - San Diego CA, US
Rose LoBello - San Diego CA, US
Jane Obara - San Diego CA, US
Eric Luo - Plano TX, US

International Classification:

A61K009/70
A61K033/00

US Classification:

424/449000, 424/722000

Abstract:

Methods are provided for enhancing the permeability of skin or mucosal tissue to topical or transdermal application of pharmacologically or cosmeceutically active agents. The methods entail the use of a base in order to increase the flux of the active agent through a body surface while minimizing the likelihood of skin damage, irritation or sensitization. The permeation enhancer can be an inorganic or organic base. Compositions and transdermal systems are also described.