Eric J Jacobson

US Patent:

20080138390, Jun 12, 2008

Filed:

Apr 7, 2005

Appl. No.:

11/547987

Inventors:

Tsung-Min Hsu - Minneapolis MN, US
Eric C. Jacobson - San Diego CA, US
Eric C. Luo - Plano TX, US
Alan T.J. Hickey - Eden Prairie MN, US
Nicole T. Gricenko - St. Louis Park MN, US

International Classification:

A61K 9/70

US Classification:

424449

Abstract:

The present invention includes transdermal delivery systems having a polymeric active agent reservoir fabricated from an admixture of polyisobutylene and an insoluble hydrophilic polymer in powdered form, which provide numerous advantages in the transdermal delivery of active agents using basic enhancer compositions. For example, the systems of the invention provide for (1) increased permeation of the active agent through the skin, (2) an improved capability of extracting the active agent and enhancer from the transdermal systems, (3) enhanced structural integrity, (4) good chemical stability, (5) reduced phase separation, and (6) decreased cold flow.

US Patent:

20080262445, Oct 23, 2008

Filed:

Sep 8, 2005

Appl. No.:

11/574928

Inventors:

Tsung-Min Hsu - Minneapolis MN, US
Alan T.J. Hickey - Eden Prairie MN, US
Eric C. Jacobson - San Diego CA, US
Nicole T. Gricenko - St. Louis Park MN, US

Assignee:

DERMATRENDS, INC. - Minneapolis MN

International Classification:

A61F 13/02
A61K 31/5513
A61K 31/5517
A61K 31/56

US Classification:

604307, 514221, 514220, 514169, 424449

Abstract:

A method and related compositions, including the use of N-acyl derivatives of sarcosine, provide for the delivery of bioactive agents through tissue surfaces such as the skin. The method and composition are particularly well suited for hydrophobic active agents such as serotonin (5HT) receptor antagonists (e.g., ondansetron), antipsychotic agents (e.g., risperidone), benzodiazepines (e.g., flumazenil), and progestins (e.g., levonorgestrel).

US Patent:

20080287502, Nov 20, 2008

Filed:

Mar 30, 2005

Appl. No.:

11/547335

Inventors:

Tsung-Min Hsu - Minneapolis MN, US
Eric C. Jacobson - San Diego CA, US
Alan T.J. Hickey - Eden Prairie MN, US
Nicole T. Gricenko - St. Louis Park MN, US
Eric C. Luo - Plano TX, US

Assignee:

DERMATRENDS, INC. - San Diego CA

International Classification:

A61K 31/4439
A61K 47/10
A61P 43/00

US Classification:

514338, 514772

Abstract:

A method and composition for the transdermal administration of proton pump inhibitors such as substituted pyridyl methylsulfinyl benzimidazoles, and in particular, omeprazole, lansoprazole, esomeprazole, pantoprazole and raberprazole. The method and composition include the use of a hydroxide-releasing agent as a permeation enhancer to increase the flux of the protein pump inhibitor through a patient's skin or mucosal tissues and optionally also include the use of a carrier such as 1,3-butanediol, dipropylene glycol, and hexylene glycol.

US Patent:

20090317453, Dec 24, 2009

Filed:

Dec 23, 2008

Appl. No.:

12/343000

Inventors:

Tsung-Min Hsu - Minneapolis MN, US
Nicole T. Gricenko - St. Louis Park MN, US
Alan T.J. Hickey - Eden Prairie MN, US
Eric C. Jacobson - San Diego CA, US
Rose C. LoBello - San Diego CA, US
Jane Obara - San Diego CA, US
Eric C. Luo - Plano TX, US

Assignee:

DERMATRENDS, INC. - Minneapolis MN

International Classification:

A61K 9/70
A61K 31/24

US Classification:

424449, 514536

Abstract:

Methods are provided for enhancing the permeability of skin or mucosal tissue to topical or transdermal application of pharmacologically or cosmeceutically active agents. The methods entail the use of a base in order to increase the flux of the active agent through a body surface while minimizing the likelihood of skin damage, irritation or sensitization. The permeation enhancer can be an inorganic or organic base. Compositions and transdermal systems are also described.