Eric P May

US Patent:

20130109019, May 2, 2013

Filed:

Jul 1, 2011

Appl. No.:

13/805978

Inventors:

Adrian E. Murillo - Tucson AZ, US
Jerome W. Kosmeder - Tucson AZ, US
Eric May - Chandler AZ, US
William Day - Tucson AZ, US
Mark Lefever - Oro Valley AZ, US
Anne M. Pedata - Tucson AZ, US
Christopher Bieniarz - Tucson AZ, US
Phillip Miller - Tucson AZ, US

International Classification:

C07D 277/54
C07C 237/20
C07D 271/12
C07D 233/90
C07D 243/00
C07D 241/52

US Classification:

435 611, 540517, 544355, 548126, 548185, 5483275, 564155, 435 28, 435 71, 435 79

Abstract:

Embodiments of hapten conjugates including a hapten, an optional linker, and a peroxidase-activatable aryl moiety are disclosed. In some embodiments, the peroxidase-activatable aryl moiety is tyramine or a tyramine derivative. Embodiments of methods for making and using the hapten conjugates also are disclosed. In particular embodiments, the hapten conjugates are used in a signal amplification assay. In certain embodiments, the hapten is an oxazole, a pyrazole, a thiazole, a benzofurazan, a triterpene, a urea, a thiourea other than a rhodamine thiourea, a nitroaryl other than dinitrophenyl or trinitrophenyl, a rotenoid, a cyclolignan, a heterobiaryl, an azoaryl, a benzodiazepine, or 7-diethylamino-3-carboxycoumarin. The hapten is coupled to the peroxidase-activatable aryl moiety directly or indirectly via a linker. In certain embodiments, the hapten conjugates are used in multiplexed assays.

US Patent:

20220306493, Sep 29, 2022

Filed:

Jun 9, 2022

Appl. No.:

17/836850

Inventors:

- Tucson AZ, US
Joseph M. Jakubowski - Georgetown TX, US
Eric May - Oro Valley AZ, US
Michael Otter - Tucson AZ, US
Taylor J. Shingler - Tucson AZ, US
Benjamin C. Stevens - Oro Valley AZ, US

International Classification:

C02F 1/32
C02F 1/72
G01N 1/31
G01N 35/00

Abstract:

Automated systems to make target compounds from slide stainer waste streams inactive utilizing advanced oxidation processes are described herein. Advanced oxidation processes are promoted by UV irradiation and further accelerated by use of radical initiators, such as hydrogen peroxide. The automated systems further include mechanisms for segregating components of the waste streams.

US Patent:

20220298028, Sep 22, 2022

Filed:

Jun 9, 2022

Appl. No.:

17/836724

Inventors:

- Tucson AZ, US
Joseph M. Jakubowski - Georgetown TX, US
Eric May - Oro Valley AZ, US
Michael Otter - Tucson AZ, US
Taylor J. Shingler - Tucson AZ, US
Benjamin C. Stevens - Oro Valley AZ, US

International Classification:

C02F 1/32
C02F 1/72
G01N 1/31
G01N 35/00

Abstract:

Automated systems to make target compounds from slide stainer waste streams inactive utilizing advanced oxidation processes are described herein. Advanced oxidation processes are promoted by UV irradiation and further accelerated by use of radical initiators, such as hydrogen peroxide. The automated systems further include mechanisms for segregating components of the waste streams.

US Patent:

20210349101, Nov 11, 2021

Filed:

Mar 17, 2021

Appl. No.:

17/203802

Inventors:

- Tucson AZ, US
Mark Lefever - Oro Valley AZ, US
Eric May - Oro Valley AZ, US

International Classification:

G01N 33/58
C09B 57/02
C09B 69/10

Abstract:

Disclosed herein are novel coumarin-based reagents, e.g. linkers, and conjugates including one or more of the disclosed coumarin-based reagents. In some embodiments, the presence of a coumarin moiety within the coumarin-based reagents enables detection of labels which are typically difficult to detect, e.g. certain haptens.

US Patent:

20200348215, Nov 5, 2020

Filed:

Jul 20, 2020

Appl. No.:

16/933658

Inventors:

- Tucson AZ, US
Brian D. Kelly - Tucson AZ, US
Eric J. May - Chandler AZ, US
Larry Morrison - Oro Valley AZ, US

International Classification:

G01N 1/30
C12Q 1/28
G01N 33/532
G01N 33/535
G01N 33/543
G01N 33/58

Abstract:

Disclosed embodiments concern a composition comprising DAB chromogen, and/or derivative thereof, a stabilizer, and polymer capable of preventing or reducing DAB precipitation relative to a composition that does not comprise the polymer. Also disclosed herein is a method for using the disclosed composition and embodiments of a kit.

US Patent:

20190300392, Oct 3, 2019

Filed:

Jun 14, 2019

Appl. No.:

16/442225

Inventors:

- Tucson AZ, US
Joseph M. Jakubowski - Georgetown TX, US
Eric May - Oro Valley AZ, US
Michael Otter - Tucson AZ, US
Taylor J. Shingler - Tucson AZ, US
Benjamin C. Stevens - Oro Valley AZ, US

International Classification:

C02F 1/32
G01N 1/31
G01N 35/00
C02F 1/72

Abstract:

Automated systems to make target compounds from slide stainer waste streams inactive utilizing advanced oxidation processes are described herein. Advanced oxidation processes are promoted by UV irradiation and further accelerated by use of radical initiators, such as hydrogen peroxide. The automated systems further include mechanisms for segregating components of the waste streams.

US Patent:

20190094242, Mar 28, 2019

Filed:

Sep 6, 2018

Appl. No.:

16/123750

Inventors:

- Tucson AZ, US
Antony Hubbard - Tucson AZ, US
Eric May - Oro Valley AZ, US
Lei Tang - Oro Valley AZ, US
Tsu-Shuen Tsao - Tucson AZ, US
Wenjun Zhang - Tucson AZ, US

International Classification:

G01N 33/68
C07K 16/28
C07K 16/18

Abstract:

The present disclosure is directed to epitope-tagged antibodies, as well as methods of employing the epitope-tagged antibodies for detecting one or more targets in a biological sample, e.g. a tissue sample.

US Patent:

20180120202, May 3, 2018

Filed:

Nov 9, 2017

Appl. No.:

15/807612

Inventors:

- Tucson AZ, US
Brian D. Kelly - Tucson AZ, US
Jerome Kosmeder, II - Tucson AZ, US
Eric May - Oro Valley AZ, US
Noemi Sebastiao - Tucson AZ, US
Pamela Wirth - Tucson AZ, US

International Classification:

G01N 1/30

Abstract:

Disclosed are compositions and methods for inactivating one or more enzymes in a biological sample.