Erika Villa Garcia

US Patent:

20210002732, Jan 7, 2021

Filed:

Mar 23, 2020

Appl. No.:

16/827590

Inventors:

- Pasadena CA, US
Mark D. Goldberg - Alta Loma CA, US
Erika F. Garcia - Los Angeles CA, US
Xiomara L. Madero - Glendale CA, US
Thomas A. Tombrello - Altadena CA, US
Axel Scherer - Bamard VT, US

International Classification:

C12Q 1/70
C12Q 1/68
C12Q 1/6851

Abstract:

Medical systems for detecting a genetic variation in a polynucleotide analyte in a sample. A fluorophore is attached to a first primer, a quencher is attached to a second primer, and the first primer and the second primer are specific for the polynucleotide analyte. The primers are configured to amplify the polynucleotide analyte having the genetic variation and a corresponding polynucleotide analyte lacking the generic variation. There is a detectable difference between a change in signal generated by the fluorophore and quencher, and measured by a sensor of the medical system, when using the first and second primers to amplify the polynucleotide analyte with the genetic variation, and a change in signal generated by the fluorophore and quencher, and measured by the sensor of the medical system, when using the first and second primers to amplify the corresponding polynucleotide analyte lacking the genetic variation.

US Patent:

20190153548, May 23, 2019

Filed:

Aug 22, 2018

Appl. No.:

16/109288

Inventors:

- PASADENA CA, US
MARK D. GOLDBERG - ALTA LOMA CA, US
ERIKA F. GARCIA - LOS ANGELES CA, US
XIOMARA L. MADERO - GLENDALE CA, US
THOMAS A. TOMBRELLO - ALTADENA CA, US
AXEL SCHERER - BARNARD VT, US

International Classification:

C12Q 1/70
C12Q 1/6851
C12Q 1/68

Abstract:

This disclosure provides methods, compositions and kits for the detection of a plurality of analytes in a sample. In some examples, this disclosure provides methods, compositions, and kits for detecting analytes, genetic variations, monitoring reaction process, and monitoring analyte-analyte interactions by measuring signals. In some examples, the presence of signals or changes in signals may be used to construct signal profiles which can be used to detect analytes.

US Patent:

20180030551, Feb 1, 2018

Filed:

Aug 11, 2017

Appl. No.:

15/675048

Inventors:

- Pasadena CA, US
Mark D. Goldberg - Alta Loma CA, US
Erika F. Garcia - Los Angeles CA, US
Xiomara L. Madero - Glendale CA, US
Thomas A. Tombrello - Altadena CA, US
Axel Scherer - Barnard VT, US

International Classification:

C12Q 1/70
C12Q 1/68

Abstract:

This disclosure provides methods, compositions and kits for the detection of a plurality of analytes in a sample. In some examples, this disclosure provides methods, compositions, and kits for detecting analytes, genetic variations, monitoring reaction process, and monitoring analyte-analyte interactions by measuring signals. In some examples, the presence of signals or changes in signals may be used to construct signal profiles which can be used to detect analytes.

US Patent:

20140213471, Jul 31, 2014

Filed:

Jan 23, 2014

Appl. No.:

14/162725

Inventors:

- Pasadena CA, US
Mark D. GOLDBERG - Alta Loma CA, US
Erika F. GARCIA - Los Angeles CA, US
Xiomara L. MADERO - Glendale CA, US
Thomas A. TOMBRELLO - Altadena CA, US
Axel SCHERER - Barnard VT, US

Assignee:

California Institute of Technology - Pasadena CA

International Classification:

C12Q 1/68
C12Q 1/70

US Classification:

506 9, 435 612, 436 94, 435 5, 435 611

Abstract:

This disclosure provides methods, compositions and kits for the detection of a plurality of analytes in a sample. In some examples, this disclosure provides methods, compositions, and kits for detecting analytes, genetic variations, monitoring reaction process, and monitoring analyte-analyte interactions by measuring signals. In some examples, the presence of signals or changes in signals may be used to construct signal profiles which can be used to detect analytes.