Erika Louise Garcia

US Patent:

20120118739, May 17, 2012

Filed:

Sep 29, 2011

Appl. No.:

13/248994

Inventors:

Sameer Walavalkar - Los Angeles CA, US
Axel Scherer - Woodstock VT, US
Thomas A. Tombrello - Altadena CA, US
Aditya Rajagopal - Irvine CA, US
Andrew P. Homyk - South Pasadena CA, US
Erika Garcia - Los Angeles CA, US

International Classification:

G01N 27/447
H01L 29/92
H01L 21/02
B82Y 15/00

US Classification:

204543, 438381, 257532, 257E29342, 257E21008, 977781, 977902

Abstract:

Methods and devices for sequencing nucleic acids are disclosed herein. Devices are also provided herein for measuring DNA with nano-pores sized to allow DNA to pass through the nano-pore. The capacitance can be measured for the DNA molecule passing through the nano-pore. The capacitance measurements can be correlated to determine the sequence of base pairs passing through the nano-pore to sequence the DNA.

US Patent:

20140057277, Feb 27, 2014

Filed:

Nov 1, 2013

Appl. No.:

14/070460

Inventors:

Erika F GARCIA - Los Angeles CA, US
Xiomara Linnette MADERO - Glendale CA, US
Axel SCHERER - Barnard VT, US

Assignee:

California Institute Of Technology - Pasadena CA

International Classification:

C12N 15/10

US Classification:

435 612, 4353061, 435 792

Abstract:

Methods and devices for biological sample preparation and analysis are disclosed. A device may have a linear or circular arrangement of containers, with a connecting structure such as a bar or disk. Fluidics channels between containers allow the performance of different techniques for sample preparation, such as lysing, washing and elution. Different functional elements, such as grinders or mixers, may be attached to the containers.

US Patent:

20140057278, Feb 27, 2014

Filed:

Nov 1, 2013

Appl. No.:

14/070465

Inventors:

Imran R MALIK - Pasadena CA, US
Erika F GARCIA - Los Angeles CA, US
Axel SCHERER - Barnard VT, US

Assignee:

California Institute Of Technology - Pasadena CA

International Classification:

C12N 15/10

US Classification:

435 612, 4353061, 435 792, 137561 R

Abstract:

Methods and devices for biological sample preparation and analysis are disclosed. A device may have a circular arrangement of containers, with a connecting structure such as a disk. Fluidics channels between containers allow the performance of different techniques for sample preparation, such as lysing, washing and elution. The device may be pen-shaped and have a sample drawing needle connected to the containers.

US Patent:

20140057279, Feb 27, 2014

Filed:

Nov 1, 2013

Appl. No.:

14/070466

Inventors:

Erika F. GARCIA - Los Angeles CA, US
Xiomara Linnette MADERO - Glendale CA, US
Axel SCHERER - Barnard VT, US

Assignee:

California Institute Of Technology - Pasadena CA

International Classification:

C12Q 1/68

US Classification:

435 612, 4352872

Abstract:

Methods and devices for biological sample preparation and analysis are disclosed. A device may have a linear or circular arrangement of containers, with a connecting structure such as a bar or disk. Fluidics channels between containers allow the performance of different techniques for sample preparation, such as lysing, washing and elution. Different functional elements, such as grinders or mixers, may be attached to the containers. The device may have a reaction cartridge with a reaction chamber to perform techniques such as polymerase chain reaction.

US Patent:

20210002732, Jan 7, 2021

Filed:

Mar 23, 2020

Appl. No.:

16/827590

Inventors:

- Pasadena CA, US
Mark D. Goldberg - Alta Loma CA, US
Erika F. Garcia - Los Angeles CA, US
Xiomara L. Madero - Glendale CA, US
Thomas A. Tombrello - Altadena CA, US
Axel Scherer - Bamard VT, US

International Classification:

C12Q 1/70
C12Q 1/68
C12Q 1/6851

Abstract:

Medical systems for detecting a genetic variation in a polynucleotide analyte in a sample. A fluorophore is attached to a first primer, a quencher is attached to a second primer, and the first primer and the second primer are specific for the polynucleotide analyte. The primers are configured to amplify the polynucleotide analyte having the genetic variation and a corresponding polynucleotide analyte lacking the generic variation. There is a detectable difference between a change in signal generated by the fluorophore and quencher, and measured by a sensor of the medical system, when using the first and second primers to amplify the polynucleotide analyte with the genetic variation, and a change in signal generated by the fluorophore and quencher, and measured by the sensor of the medical system, when using the first and second primers to amplify the corresponding polynucleotide analyte lacking the genetic variation.

US Patent:

20190153548, May 23, 2019

Filed:

Aug 22, 2018

Appl. No.:

16/109288

Inventors:

- PASADENA CA, US
MARK D. GOLDBERG - ALTA LOMA CA, US
ERIKA F. GARCIA - LOS ANGELES CA, US
XIOMARA L. MADERO - GLENDALE CA, US
THOMAS A. TOMBRELLO - ALTADENA CA, US
AXEL SCHERER - BARNARD VT, US

International Classification:

C12Q 1/70
C12Q 1/6851
C12Q 1/68

Abstract:

This disclosure provides methods, compositions and kits for the detection of a plurality of analytes in a sample. In some examples, this disclosure provides methods, compositions, and kits for detecting analytes, genetic variations, monitoring reaction process, and monitoring analyte-analyte interactions by measuring signals. In some examples, the presence of signals or changes in signals may be used to construct signal profiles which can be used to detect analytes.

US Patent:

20180030551, Feb 1, 2018

Filed:

Aug 11, 2017

Appl. No.:

15/675048

Inventors:

- Pasadena CA, US
Mark D. Goldberg - Alta Loma CA, US
Erika F. Garcia - Los Angeles CA, US
Xiomara L. Madero - Glendale CA, US
Thomas A. Tombrello - Altadena CA, US
Axel Scherer - Barnard VT, US

International Classification:

C12Q 1/70
C12Q 1/68

Abstract:

This disclosure provides methods, compositions and kits for the detection of a plurality of analytes in a sample. In some examples, this disclosure provides methods, compositions, and kits for detecting analytes, genetic variations, monitoring reaction process, and monitoring analyte-analyte interactions by measuring signals. In some examples, the presence of signals or changes in signals may be used to construct signal profiles which can be used to detect analytes.

US Patent:

20140213471, Jul 31, 2014

Filed:

Jan 23, 2014

Appl. No.:

14/162725

Inventors:

- Pasadena CA, US
Mark D. GOLDBERG - Alta Loma CA, US
Erika F. GARCIA - Los Angeles CA, US
Xiomara L. MADERO - Glendale CA, US
Thomas A. TOMBRELLO - Altadena CA, US
Axel SCHERER - Barnard VT, US

Assignee:

California Institute of Technology - Pasadena CA

International Classification:

C12Q 1/68
C12Q 1/70

US Classification:

506 9, 435 612, 436 94, 435 5, 435 611

Abstract:

This disclosure provides methods, compositions and kits for the detection of a plurality of analytes in a sample. In some examples, this disclosure provides methods, compositions, and kits for detecting analytes, genetic variations, monitoring reaction process, and monitoring analyte-analyte interactions by measuring signals. In some examples, the presence of signals or changes in signals may be used to construct signal profiles which can be used to detect analytes.